Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes.

A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid

1956 • 14,202 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

1989 • 1,095 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

Interleukin 1: An Immunological Perspective

1985 • 576 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

Calcium‐activated DNA fragmentation kills immature thymocytes

1989 • 533 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

2,3,7,8-Tetrachlorodibenzo- p -Dioxin Kills Immature Thymocytes by Ca ²⁺ -Mediated Endonuclease Activation

1988 • 460 citations

Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism

1988 • 413 citations

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

1987 • 391 citations

Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex.

1989 • 315 citations

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

1987 • 310 citations

Modulation of protein kinase C and diverse cell functions by sphingosine — a pharmacologically interesting compound linking sphingolipids and signal transduction

1989 • 281 citations

Inhibition of DNA Fragmentation in Thymocytes and Isolated Thymocyte Nuclei by Agents That Stimulate Protein Kinase C

1989 • 276 citations

Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage

1988 • 265 citations

Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells.

1988 • 260 citations

Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment

1988 • 197 citations

Attenuation of sn-1,2-diacylglycerol second messengers. Metabolism of exogenous diacylglycerols by human platelets.

1986 • 106 citations

Thymic cortical epithelial cells lack full capacity for antigen presentation

1989 • 85 citations

Expression and role of the T cell receptor in early thymocyte differentiation in vitro.

1987 • 66 citations