Developing chemokine mutants with improved proteoglycan affinity and knocked-out GPCR activity as anti-inflammatory recombinant drugs
Data up to Jan 2025
Total Citations Per Year
Abstract
References (13)
C<scp>hemokines in</scp>I<scp>nnate and</scp>A<scp>daptive</scp>H<scp>ost</scp>D<scp>efense</scp>: Basic Chemokinese Grammar for Immune Cells
2004 • 1,199 citations
Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines
2003 • 756 citations
Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1
1997 • 724 citations
Glycosaminoglycan-protein interactions: definition of consensus sites in glycosaminoglycan binding proteins
1998 • 541 citations
Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities.
1991 • 425 citations
Identification of a Glycosaminoglycan Binding Surface on Human Interleukin-8
1998 • 178 citations
Amino-terminally Modified RANTES Analogues Demonstrate Differential Effects on RANTES Receptors
1999 • 154 citations
A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4.
1995 • 143 citations
Different Affinities of Glycosaminoglycan Oligosaccharides for Monomeric and Dimeric Interleukin-8: A Model for Chemokine Regulation at Inflammatory Sites
2002 • 130 citations
Proteoglycans guide SDF-1-induced migration of hematopoietic progenitor cells
2002 • 100 citations
Surface expression of CC- and CXC-chemokine receptors on leucocyte subsets in inflammatory joint diseases
2001 • 75 citations
Expression of the Duffy antigen/receptor for chemokines (DARC) by the inflamed synovial endothelium
2002 • 63 citations
A structural and dynamic model for the interaction of interleukin‐8 and glycosaminoglycans: Support from isothermal fluorescence titrations
2004 • 58 citations