The majority of intestinal IgA+ and IgG+ plasmablasts in the human gut are antigen-specific

A human gut microbial gene catalogue established by metagenomic sequencing

2010 • 10,392 citations

Sequences of proteins of immunological interest

1984 • 3,427 citations

Predominant Autoantibody Production by Early Human B Cell Precursors

2003 • 1,966 citations

Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

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A Primitive T Cell-Independent Mechanism of Intestinal Mucosal IgA Responses to Commensal Bacteria

2000 • 1,085 citations

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

2007 • 1,029 citations

IgA Response to Symbiotic Bacteria as a Mediator of Gut Homeostasis

2007 • 773 citations

Cardiolipin Polyspecific Autoreactivity in Two Broadly Neutralizing HIV-1 Antibodies

2005 • 732 citations

Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut

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Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora

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Protective Effect of Rotavirus VP6-Specific IgA Monoclonal Antibodies That Lack Neutralizing Activity

1996 • 487 citations

Metagenomic Approaches for Defining the Pathogenesis of Inflammatory Bowel Diseases

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Autoreactivity in Human IgG+ Memory B Cells

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Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria.

1996 • 437 citations

Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins

1984 • 415 citations

Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties

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Secretory Component

2002 • 399 citations

Segmented Filamentous Bacteria Are Potent Stimuli of a Physiologically Normal State of the Murine Gut Mucosal Immune System

1999 • 370 citations

The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA.

1991 • 346 citations

Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium

1992 • 343 citations

Innate secretory antibodies protect against natural Salmonella typhimurium infection

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A checkpoint for autoreactivity in human IgM+ memory B cell development

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Natural polyreactive secretory immunoglobulin A autoantibodies as a possible barrier to infection in humans

1997 • 201 citations

Secretory IgA-Mediated Neutralization of Shigella flexneri Prevents Intestinal Tissue Destruction by Down-Regulating Inflammatory Circuits

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Secretory IgA Mediates Bacterial Translocation to Dendritic Cells in Mouse Peyer’s Patches with Restriction to Mucosal Compartment

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Surrogate Light Chain Expressing Human Peripheral B Cells Produce Self-reactive Antibodies

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Monoclonal immunoglobulin A derived from peritoneal B cells is encoded by both germ line and somatically mutated VH genes and is reactive with commensal bacteria

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Diversity of Antibody-Mediated Immunity at the Mucosal Barrier

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Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity

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Hypermutation, diversity and dissemination of human intestinal lamina propria plasma cells

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Sequence analysis of human IgV_H genes indicates that ileal lamina propria plasma cells are derived from Peyer's patches

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Intestinal B-cell isotype response in relation to local bacterial load: Evidence for immunoglobulin A subclass adaptation

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Recognition of secretory IgA by DC-SIGN: Implications for immune surveillance in the intestine

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Immunohistochemical Characterization of Local Immunoglobulin Formation in Crohn’s Disease of the Ileum

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Human IgA- and IgM-secreting intestinal plasma cells carry heavily mutated VH region genes

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Rotavirus-Specific B Cells Induced by Recent Infection in Adults and Children Predominantly Express the Intestinal Homing Receptor α4β7

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Development of Mucosal Humoral Immune Responses in Germ-Free (GF) Mice

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Terminally Differentiated Human Intestinal B Cells

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Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction

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Evidence for Local Expansion of IgA Plasma Cell Precursors in Human Ileum

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Somatic mutations can lead to a loss of superantigenic and polyreactive binding

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Identification and Use of Protective Monoclonal IgA Antibodies Against Viral and Bacterial Pathogens

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