Predicting chemoresistance in human malignant glioma cells: The role of molecular genetic analyses

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

Analysis of the p53 gene and its expression in human glioblastoma cells.

1994 • 329 citations

Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation.

1995 • 258 citations

Predicting response to cancer chemotherapy: the role of p53

1998 • 226 citations

Immunohistochemical analysis of Bcl-2, Bcl-X, Mcl-1, and Bax in tumors of central and peripheral nervous system origin.

1997 • 145 citations

The relationship between TP53 mutations and overexpression of p53 and prognosis in malignant gliomas of childhood.

1997 • 144 citations

Association of EGFR Gene Amplification and CDKN2 (p16/MTS1) Gene Deletion in Glioblastoma Multiforme

1997 • 130 citations

Replacement of the p16/CDKN2 gene suppresses human glioma cell growth.

1995 • 114 citations

Effects of hypoxia on drug resistance phenotype and genotype in human glioma cell lines

1996 • 105 citations

Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro

1997 • 96 citations

Chemotherapy of human malignant glioma

1997 • 88 citations

Topoisomerase-I inhibitors for human malignant glioma: Differential modulation of p53, p21, bax and bcl-2 expression and of CD95-mediated apoptosis by camptothecin and β-lapachone

1997 • 82 citations

BCL-2 family protein expression in human malignant glioma: a clinical-pathological correlative study

1998 • 78 citations

Amplification of the cyclin-dependent kinase 4 ( CDK4 ) gene is associated with high cdk4 protein levels in glioblastoma multiforme

1996 • 71 citations

Prognostic Implications of p53 Overexpression in Supratentorial Astrocytic Tumors

1994 • 70 citations

Prognostic indicators in a range of astrocytic tumours: an immunohistochemical study with Ki-67 and p53 antibodies.

1995 • 65 citations

Prognostic significance of p53 immunoreactivity in patients with glioma.

1995 • 53 citations

Chemosensitivity of human malignant glioma: modulation by p53 gene transfer.

1998 • 48 citations

bcl-2 protein expression in astrocytomas in relation to patient survival and p53 gene status

1997 • 47 citations

Genetic instability leads to loss of both p53 alleles in a human glioblastoma

1998 • 44 citations

Functional analysis of wild-type and malignant glioma derived CDKN2Aβ alleles: Evidence for an RB-independent growth suppressive pathway

1997 • 32 citations