Protein phosphotyrosine phosphatase purified from the particulate fraction of human placenta dephosphorylates insulin and growth-factor receptors

Growth factors: Mechanism of action and relation to oncogenes

1984 • 885 citations

Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate

1982 • 699 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

Purification of the major protein-tyrosine-phosphatases of human placenta.

1988 • 564 citations

Characterization of the major protein-tyrosine-phosphatases of human placenta.

1988 • 554 citations

A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.

1988 • 467 citations

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

1987 • 399 citations

Cytoskeletal elements of chick embryo fibroblasts revealed by detergent extraction

1976 • 398 citations

Isolation of the Insulin Receptor of Liver and Fat-Cell Membranes

1972 • 397 citations

Allosteric regulation of the epidermal growth factor receptor kinase.

1986 • 381 citations

The detergent-resistant cytoskeleton of tissue culture cells includes the nucleus and the microfilament bundles

1977 • 316 citations

Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn.

1981 • 277 citations

Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells.

1985 • 218 citations

Mechanism of epidermal growth factor receptor autophosphorylation and high-affinity binding.

1987 • 209 citations

Identification of insulin receptor tyrosine residues autophosphorylated in vitro.

1987 • 182 citations

Association of p60src with Triton X-100-resistant cellular structure correlates with morphological transformation.

1987 • 163 citations

Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.

1988 • 128 citations

Characterization of a rabbit skeletal muscle protein kinase (PC0.7) able to phosphorylate glycogen synthase and phosvitin.

1981 • 99 citations

Cytosolic protein phosphotyrosine phosphatases from rabbit kidney. Purification of two distinct enzymes that bind to Zn2+-iminodiacetate agarose.

1984 • 96 citations

Detection of a novel mammalian protein phosphatase with activity for phosphotyrosine

1981 • 80 citations

Identification, purification, and characterization of phosphotyrosine-specific protein phosphatases from cultured chicken embryo fibroblasts.

1984 • 77 citations

Advances in protein phosphatases

1985 • 75 citations

Tyrosine protein kinases.

1984 • 64 citations

Partial purification and characterization of phosphotyrosyl-protein phosphatase from Ehrlich ascites tumor cells

1982 • 60 citations

Separation of the high affinity insulin-like growth factor I receptor from low affinity binding sites by affinity chromatography.

1987 • 58 citations

Tyrosylprotein kinase and phosphatase activities in membrane vesicles from normal and Rous sarcoma virus-transformed rat cells.

1981 • 44 citations

Membrane protein phosphotyrosine phosphatase in rabbit kidney. Proteolysis activates the enzyme and generates soluble catalytic fragments

1987 • 36 citations

The insulin receptor and tyrosine protein kinase activity

1984 • 32 citations

Identification, Purification, and Characterization of Phosphotyrosine-Specific Protein Phosphatases from Cultured Chicken Embryo Fibroblasts

1984 • 27 citations

Partial purification and characterization of phosphotyrosyl-protein phosphatase(S) from human erythrocyte cytosol

1986 • 26 citations

Demonstration of separate phosphotyrosyl- and phosphoseryl-histone phosphatase activities in the plasma membranes of a human astrocytoma

1985 • 23 citations

A protein phosphotyrosine phosphatase distinct from alkaline phosphatase with activity against the insulin receptor

1988 • 13 citations

Metal chelate affinity chromatography of Zn2+-inhibited protein Tyr(P) phosphatases

1987 • 5 citations