Distinct roles for matrix metalloproteinase-2 and α4 integrin in autoimmune T cell extravasation and residency in brain parenchyma during experimental autoimmune encephalomyelitis

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Quantitative Zymography: Detection of Picogram Quantities of Gelatinases

1994 • 866 citations

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

1993 • 837 citations

T cell gelatinases mediate basement membrane transmigration in vitro.

1995 • 507 citations

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

1996 • 349 citations

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

1994 • 338 citations

Regulation of gamma‐glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells

1994 • 313 citations

Interferon beta‐1b inhibits gelatinase secretion and in vitro migration of human T cells: A possible mechanism for treatment efficacy in multiple sclerosis

1996 • 302 citations

Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis

1996 • 278 citations

Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis.

1993 • 277 citations

Animal models

1994 • 276 citations

The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function.

1989 • 264 citations

Animal models of human disease Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease

1995 • 218 citations

Molecular cloning of murine 72-kDa type IV collagenase and its expression during mouse development.

1992 • 189 citations

Stimulus specificity of matrix metalloproteinase dependence of human T cell migration through a model basement membrane.

1996 • 173 citations

Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790

1995 • 146 citations

Stimulation of matrix metalloproteinase‐dependent migration of T cells by eicosanoids

1995 • 128 citations

Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors

1998 • 124 citations

T cells with two functional antigen-specific receptors.

1995 • 119 citations

VLA-4 expression on peripheral blood lymphocytes is downregulated after treatment of multiple sclerosis with interferon beta

1997 • 119 citations

The glycosyl phosphatidylinositol anchor is critical for Ly-6A/E-mediated T cell activation.

1991 • 99 citations

Development of colonies in vitro of mitogen-stimulated mouse T lymphocytes

1976 • 68 citations

The interrelationship of alpha4 integrin and matrix metalloproteinase-2 in the pathogenesis of experimental autoimmune encephalomyelitis.

1998 • 66 citations

Therapy with antibody against leukocyte integrin VLA-4 (CD49d) is effective and safe in virus-facilitated experimental allergic encephalomyelitis

1997 • 66 citations

Evidence for a prolonged role of alpha sub 4 integrin throughout active experimental allergic encephalomyelitis

1996 • 61 citations

T cell adhesion to endothelial cells and extracellular matrix is modulated upon transendothelial cell migration.

1997 • 50 citations

Integrin-dependent role of human T cell matrix metalloproteinase activity in chemotaxis through a model basement membrane.

1996 • 31 citations

Integrin-dependent role of human T cell matrix metalloproteinase activity in chemotaxis through a model basement membrane

1996 • 23 citations

The Relationship between Human Multiple Sclerosis and Rodent Experimental Allergic Encephalomyelitis

1995 • 12 citations