Platelet-inhibitor drugs' role in coronary artery disease

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Prevalence of Total Coronary Occlusion during the Early Hours of Transmural Myocardial Infarction

1980 • 2,722 citations

Nonoperative Dilatation of Coronary-Artery Stenosis

1979 • 2,441 citations

The Inverse Relation between Fish Consumption and 20-Year Mortality from Coronary Heart Disease

1985 • 2,210 citations

Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina.

1985 • 2,003 citations

A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro

1974 • 1,838 citations

Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina

1983 • 1,740 citations

Thrombosis and Acute Coronary-Artery Lesions in Sudden Cardiac Ischemic Death

1984 • 1,700 citations

EICOSAPENTAENOIC ACID AND PREVENTION OF THROMBOSIS AND ATHEROSCLEROSIS?

1978 • 1,689 citations

Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets

1974 • 1,410 citations

Deficiency of protein C in congenital thrombotic disease.

1981 • 1,260 citations

Arachidonic Acid Metabolites and the Interactions between Platelets and Blood-Vessel Walls

1979 • 1,158 citations

Aspirin, Sulfinpyrazone, or Both in Unstable Angina

1985 • 1,146 citations

Restenosis after percutaneous transluminal coronary angioplasty (PTCA): A report from the PTCA registry of the national heart, lung, and blood institute

1984 • 1,122 citations

Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion.

1985 • 1,053 citations

Inherited Antithrombin Deficiency Causing Thrombophilia

1965 • 1,040 citations

Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis. Characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi.

1983 • 1,023 citations

Acetylation of prostaglandin synthase by aspirin.

1975 • 1,003 citations

Selective Cumulative Inhibition of Platelet Thromboxane Production by Low-dose Aspirin in Healthy Subjects

1982 • 940 citations

Coronary Angioscopy in Patients with Unstable Angina Pectoris

1986 • 877 citations

The effect of adenosine and adenine nucleotides on the cyclic adenosine 3', 5'-phosphate content of guinea pig cerebral cortex slices.

1970 • 860 citations

Medicine and the Law

1969 • 849 citations

Angiographie morphology and the pathogenesis of unstable angina pectoris

1985 • 811 citations

Cancer Research: Some Forward Steps

1965 • 733 citations

Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium

1977 • 683 citations

Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man.

1983 • 675 citations

Balloon angioplasty. Natural history of the pathophysiological response to injury in a pig model.

1985 • 633 citations

"AICLA" controlled trial of aspirin and dipyridamole in the secondary prevention of athero-thrombotic cerebral ischemia.

1983 • 615 citations

Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets

1977 • 601 citations

A Platelet-Inhibitor-Drug Trial in Coronary-Artery Bypass Operations

1982 • 550 citations

Intramyocardial platelet aggregation in patients with unstable angina suffering sudden ischemic cardiac death.

1986 • 542 citations

Effect of Dipyridamole and Aspirin on Late Vein-Graft Patency after Coronary Bypass Operations

1984 • 529 citations

A Randomized Controlled Trial of Acetyl Salicyclic Acid in the Secondary Prevention of Mortality from Myocardial Infarction

1974 • 517 citations

Coronary Arterial Smooth Muscle Contraction by a Substance Released from Platelets: Evidence That It Is Thromboxane A ₂

1976 • 504 citations

Morphology after Transluminal Angioplasty in Human Beings

1981 • 484 citations

Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion.

1985 • 472 citations

The mechanism of balloon angioplasty.

1980 • 472 citations

Persantine and aspirin in coronary heart disease. The Persantine-Aspirin Reinfarction Study Research Group.

1980 • 464 citations

Angiographic evolution of coronary artery morphology in unstable angina

1986 • 464 citations

A Randomized, Controlled Trial of Aspirin in Persons Recovered From Myocardial Infarction

1980 • 462 citations

Vasoconstriction: A New Activity for Platelet-Derived Growth Factor

1986 • 430 citations

The influence on platelet aggregation of drugs that affect the accumulation of adenosine 3′:5′-cyclic monophosphate in platelets

1971 • 422 citations

Molecular mechanism of physiological fibrinolysis

1978 • 410 citations

Significance of the angiographic morphology of localized coronary stenoses: histopathologic correlations.

1982 • 410 citations

Coronary angiographic morphology in myocardial infarction: A link between the pathogenesis of unstable angina and myocardial infarction

1985 • 407 citations

Percutaneous transluminal coronary angioplasty: Report from the registry of the National Heart, Lung, and Blood Institute

1982 • 406 citations

DIPYRIDAMOLE AND OTHER PHOSPHODIESTERASE INHIBITORS ACT AS ANTITHROMBOTIC AGENTS BY POTENTIATING ENDOGENOUS PROSTACYCLIN

1978 • 392 citations

Synthesis of Prostacyclin from Platelet-derived Endoperoxides by Cultured Human Endothelial Cells

1980 • 385 citations

BATTERED BABIES—HOW MANY DO WE MISS?

1970 • 365 citations

The role of lipids in platelet function: with particular reference to the arachidonic acid pathway.

1978 • 364 citations

Coumadin and aspirin in prevention of recurrence after transluminal coronary angioplasty: a randomized study.

1984 • 363 citations

ASPIRIN AND SECONDARY MORTALITY AFTER MYOCARDIAL INFARCTION

1979 • 361 citations

Pharmacologic Control of Thromboembolic Complications of Cardiac-Valve Replacement

1971 • 353 citations

Sulfinpyrazone in the Prevention of Sudden Death after Myocardial Infarction

1980 • 335 citations

Studies of Platelet and Fibrinogen Kinetics in Patients with Prosthetic Heart Valves

1970 • 334 citations

TRIAL OF HEPARIN VERSUS ATENOLOL IN PREVENTION OF MYOCARDIAL INFARCTION IN INTERMEDIATE CORONARY SYNDROME

1981 • 327 citations

IMPROVED AORTOCORONARY BYPASS PATENCY BY LOW-DOSE ASPIRIN (100 mg DAILY)

1984 • 319 citations

Intracoronary thrombus: Role in coronary occlusion complicating percutaneous transluminal coronary angioplasty

1985 • 316 citations

Provision of medicine in Ecuador.

1980 • 314 citations

The role of prostacyclin in vascular tissue.

1979 • 312 citations

Trial of combined warfarin plus dipyridamole or aspirin therapy in prosthetic heart valve replacement: Danger of aspirin compared with dipyridamole

1983 • 311 citations

Aspirin in coronary heart disease

1976 • 311 citations

Recovery of Endothelial Cell Prostacyclin Production after Inhibition by Low Doses of Aspirin

1979 • 310 citations

Aspirin Use in Patients with Major Upper Gastrointestinal Bleeding and Peptic-Ulcer Disease

1974 • 304 citations

Transluminal coronary angioplasty and early restenosis. Fibrocellular occlusion after wall laceration.

1983 • 302 citations

Persantine Aspirin Trial in cerebral ischemia. Part II: Endpoint results. The American-Canadian Co-Operative Study group.

1985 • 284 citations

Resistance to Arteriosclerosis in Pigs with von Willebrand's Disease

1978 • 279 citations

Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation?

1982 • 276 citations

Dipyridamole inhibition of adenosine metabolism in human blood

1983 • 263 citations

Arachidonate metabolism in vascular disorders.

1983 • 243 citations

Aspirin and the Stomach

1986 • 238 citations

SUPRASTRIATE HEMIANOPIA

1974 • 232 citations

Application of imidazole as a selective inhibitor thromboxane synthetase in human platelets.

1977 • 215 citations

Platelet survival and the development of coronary artery disease in the young adult: effects of cigarette smoking, strong family history and medical therapy.

1981 • 208 citations

Role of platelets and thrombosis in coronary atherosclerotic disease and sudden death

1985 • 202 citations

Thrombogenic Effect of High-Dose Aspirin in Rabbits

1978 • 191 citations

Inhibition of platelet function by organic nitrate vasodilators

1980 • 187 citations

The mechanism of transluminal angioplasty: evidence for formation of aneurysms in experimental atherosclerosis.

1983 • 182 citations

Prostacyclin (prostaglandin I2, PGI2) inhibits platelet adhesion and thrombus formation on subendothelium

1979 • 176 citations

DIABETOGENIC NITROSAMINES?

1974 • 175 citations

Platelet activation.

1985 • 172 citations

Improved graft patency in patients treated with platelet-inhibiting therapy after coronary bypass surgery.

1985 • 172 citations

Influence of intimal dissection on restenosis after successful coronary angioplasty.

1985 • 170 citations

The hemostatic plug.

1977 • 169 citations

ADMINISTRATION TO MAN OF UK-37,248-01, A SELECTIVE INHIBITOR OF THROMBOXANE SYNTHETASE

1981 • 168 citations

Thrombolytic therapy in patients with acute myocardial infarction.

1985 • 160 citations

Effect of prostacyclin (PGI2) on platelet adhesion to rabbit arterial subendothelium

1978 • 157 citations

THROMBOXANE SYNTHETASE INHIBITION AS ANTITHROMBOTIC STRATEGY

1981 • 145 citations

Warfarin

1984 • 144 citations

Dipyridamole Inhibits Platelet Aggregation in Whole Blood

1983 • 143 citations

Gastric mucosa and susceptibility to occult gastrointestinal bleeding caused by aspirin.

1967 • 138 citations

Role of platelets and platelet inhibitors in aortocoronary artery vein-graft disease.

1986 • 129 citations

Scanning electron microscopy after coronary transluminal angioplasty of normal canine coronary arteries

1980 • 128 citations

Effects of platelet-modifying drugs on arterial thromboembolism in baboons. Aspirin potentiates the antithrombotic actions of dipyridamole and sulfinpyrazone by mechanism(s) independent of platelet cyclooxygenase inhibition.

1985 • 123 citations

PROSTACYCLIN TO PREVENT PLATELET ACTIVATION DURING CHARCOAL HÆMOPERFUSION IN FULMINANT HEPATIC FAILURE

1980 • 123 citations

Platelet and fibrinogen survival in coronary atherosclerosis

1977 • 117 citations

Coronary Arteries in Fatal Acute Myocardial Infarction

1972 • 117 citations

Identification in vitro of an endothelial cell surface cofactor for antithrombin III. Parallel studies with isolated perfused rat hearts and microcarrier cultures of bovine endothelium.

1982 • 116 citations

Altered Platelet Function in Patients with Prosthetic Mitral Valves Effects of Sulfinpyrazone Therapy

1970 • 116 citations

Failure of thromboxane A2 blockade to prevent attacks of vasospastic angina.

1982 • 115 citations

Comparison of Progressive Antithrombin Activity and the Concentrations of Three Thrombin Inhibitors in Human Plasma

1970 • 114 citations

Mural platelet microthrombi and major acute lesions of main epicardial arteries in sudden coronary death

1974 • 108 citations

Experimental Arterial Thromboembolism in Baboons

1979 • 107 citations

Pharmacology of platelet-affecting drugs.

1980 • 103 citations

Platelet Survival and Adhesiveness in Recurrent Venous Thrombosis

1973 • 95 citations

Arteriosclerosis in normal and von Willebrand pigs: long-term prospective study and aortic transplantation study.

1982 • 92 citations

Effects of aspirin and dipyridamole on the degradation of adenosine diphosphate by cultured cells derived from bovine pulmonary artery.

1980 • 89 citations

Effect of sodium bicarbonate on aspirin-induced damage and potential difference changes in human gastric mucosa

1977 • 88 citations

Enhanced platelet accumulation onto injured carotid arteries in rabbits after aspirin treatment.

1981 • 87 citations

ROLE OF VON WILLEBRAND FACTOR IN PLATELET ADHESION TO THE SUBENDOTHELIUM

1983 • 86 citations

Secondary Prevention of Myocardial Infarction Comparison of Acetylsalicylic Acid, Phenprocoumon and Placebo

1979 • 85 citations

Protective Effect of Cimetidine on Aspirin-Induced Gastric Mucosal Damage

1977 • 84 citations

Balloon angioplasty in multivessel coronary artery disease.

1983 • 80 citations

Aspirin as an Antithrombotic Medication

1983 • 79 citations

Aspirin inhibits platelet function independent of the acetylation of ciclo-oxygenase

1982 • 78 citations

Ticlopidine - An antiplatelet drug: Effects in human volunteers

1978 • 77 citations

BM 13.177, A SELECTIVE BLOCKER OF PLATELET AND VESSEL WALL THROMBOXANE RECEPTORS, IS ACTIVE IN MAN

1984 • 75 citations

THE SIGNIFICANCE OF TURBULENCE IN HEMIC SYSTEMS AND IN THE DISTRIBUTION OF THE ATHEROSCLEROTIC LESION.

1965 • 72 citations

Prostacyclin substitution for heparin in long-term hemodialysis

1982 • 68 citations

Acetylsalicylic acid and dipyridamole improve the early patency of aorta-coronary bypass grafts. A double-blind, placebo-controlled, randomized trial.

1985 • 68 citations

Prostaglandins and thromboxanes: "middlemen" modulating platelet function in hemostasis and thrombosis.

1978 • 66 citations

De-aggregatory action of prostacyclin and its enhancement by theophylline

1978 • 63 citations

Reversible and irreversible inhibition of platelet cyclooxygenase and serotonin release by nonsteroidal antiinflammatory drugs

1978 • 61 citations

Effect of aspirin on prevention of coronary and cerebrovascular disease in patients with rheumatoid arthritis. A long-term follow-up study.

1978 • 61 citations

ROLE OF VON WILLEBRAND FACTOR IN PLATELET ADHESION TO THE SUBENDOTHELIUM

1983 • 59 citations

Compared effects of three dose-levels of ticlopidine on platelet function in normal subjects

1979 • 58 citations

Effect of Pharmaceutical Formulation on Gastrointestinal Bleeding From Aspirin Tablets

1972 • 57 citations

Acetylsalicylic acid and dipyridamole improve the early patency of aorta-coronary bypass grafts

1985 • 55 citations

Percutaneous transluminal coronary angioplasty in multivessel disease

1983 • 53 citations

Sudden coronary death: Comparison of patients with to those without coronary thrombus at necropsy

1984 • 53 citations

Aspirin in coronary heart disease. Comparison of six clinical trials.

1983 • 53 citations

Aortocoronary artery vein-graft disease: experimental and clinical approach for the understanding of the role of platelets and platelet inhibitors.

1985 • 51 citations

Possible significance of small numbers of functional platelets in a population of aspirin-treated platelets in vitro and in vivo

1980 • 51 citations

Salicylate-induced gastrointestinal bleeding: comparison between soluble buffered, enteric-coated, and intravenous administration.

1979 • 50 citations

Favorable effect of sulfinpyrazone on thromboembolism in patients with rheumatic heart disease.

1980 • 47 citations

Platelet suppressant therapy in patients with prosthetic cardiac valves. Relationship of clinical effectiveness to alteration of platelet survival time.

1979 • 47 citations

The prolonged effect of sulfinpyrazone on collagen-induced platelet aggregation in vivo

1978 • 46 citations

Evaluation of antiplatelet agents in the prevention of aorto-coronary bypass occlusion*

1986 • 44 citations

Comparison of the antithrombotic action of calcium antagonist drugs with dipyridamole in dogs

1983 • 42 citations

Interaction of platelets with the vessel wall

1985 • 40 citations

Synthesis of thromboxane B2 and prostaglandins by bovine gastric mucosal microsomes

1977 • 37 citations

Blood coagulation and idiopathic thromboembolism among fertile women

1980 • 36 citations

Platelet-Suppressant Therapy in Patients With Coronary Artery Disease

1978 • 36 citations

Selective inhibition of thromboxane-related platelet function by low-dose aspirin in patients after myocardial infarction

1985 • 33 citations

Balloon angioplasty—Natural history of the pathophysiological response to injury in a pig model

1987 • 28 citations

10. Antithrombotic therapy: role of platelet-inhibitor drugs. II. Pharmacologic effects of platelet-inhibitor drugs (second of three parts).

1981 • 25 citations

The In Vitro Effect of Ticlopidine on Fibrinogen and Factor VIII Binding to Human Platelets

1981 • 24 citations

Pharmacology of Platelet-Suppressive Agents

2008 • 23 citations

Effects of platelet suppressant, anticoagulant and fibrinolytic therapy in patients with recurrent venous thrombosis

1978 • 23 citations

An Overview of Antiplatelet and Antithrombotic Drugs

1985 • 21 citations

Is the Antithrombotic Activity of “Antiplatelet” Drugs Based on Protection of Endothelium?

1979 • 15 citations

Dose Antiplatelet Agents; The Relationship Among Side Effects, and Antithrombotic Effectiveness

1986 • 13 citations

Series on pharmacology in practice. 10. Antithrombotic therapy: role of platelet-inhibitor drugs. III. Management of arterial thromboembolic and atherosclerotic disease (third of three parts).

1981 • 11 citations

Coronary artery bypass grafting. A model for the understanding of the progression of atherosclerotic disease and the role of pharmacological intervention.

1985 • 3 citations

The In Vitro Effect Of Ticlopidine On Fibrinogen And Factor VIII Binding To Human Platelets

1981 • 2 citations

Deleted Work

1955 • 0 citations