Arachidonate metabolism in vascular disorders.

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Arachidonic Acid Metabolites and the Interactions between Platelets and Blood-Vessel Walls

1979 • 1,158 citations

Acetylation of prostaglandin synthase by aspirin.

1975 • 1,003 citations

Selective Cumulative Inhibition of Platelet Thromboxane Production by Low-dose Aspirin in Healthy Subjects

1982 • 940 citations

The chemical structure of prostaglandin X (prostacyclin)

1976 • 729 citations

Stimulation of Endothelial Cell Prostacyclin Production by Thrombin, Trypsin, and the Ionophore A 23187

1978 • 715 citations

Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man.

1983 • 675 citations

Inhibition of platelet prostaglandin synthetase by oral aspirin.

1978 • 552 citations

Differential Inhibition by Aspirin of Vascular and Platelet Prostaglandin Synthesis in Atherosclerotic Patients

1983 • 460 citations

Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin.

1977 • 409 citations

Dietary enrichment with the polyunsaturated fatty acid eicosapentaenoic acid prevents proteinuria and prolongs survival in NZB x NZW F1 mice.

1981 • 328 citations

Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate.

1983 • 312 citations

Recovery of Endothelial Cell Prostacyclin Production after Inhibition by Low Doses of Aspirin

1979 • 310 citations

Inhibition of Prostacyclin and Platelet Thromboxane A₂after Low-Dose Aspirin

1981 • 278 citations

Estimated rate of prostacyclin secretion into the circulation of normal man.

1981 • 271 citations

Prevention of Thrombosis in Patients on Hemodialysis by Low-Dose Aspirin

1979 • 248 citations

Identification and properties of two distinct phosphatidylinositol-specific phospholipase C enzymes from sheep seminal vesicular glands.

1982 • 248 citations

Discovery of an arachidonoyl coenzyme A synthetase in human platelets.

1982 • 241 citations

Formation of lysophosphatidylcholine by human platelets in response to thrombin. Support for the phospholipase A2 pathway for the liberation of arachidonic acid.

1981 • 217 citations

DIFFERENTIAL INHIBITION BY LOW-DOSE ASPIRIN OF HUMAN VENOUS PROSTACYCLIN SYNTHESIS AND PLATELET THROMBOXANE SYNTHESIS

1981 • 200 citations

Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267.

1982 • 199 citations

Utilization of arachidonic and linoleic acids by cultured human endothelial cells.

1981 • 175 citations

Cardiac and Renal Prostaglandin I2

1978 • 174 citations

Novel prostaglandin derivative formed from arachidonic acid by rat stomach homogenates

1971 • 163 citations

Sensitivity of fatty acid cyclooxygenase from human aorta to acetylation by aspirin.

1978 • 150 citations

Prevention of Glomerulonephritis and Prolonged Survival in New Zealand Black/New Zealand White F1 Hybrid Mice Fed an Essential Fatty Acid-deficient Diet

1981 • 145 citations

The effects of mepacrine and p-bromophenacyl bromide on arachidonic acid release in human platelets

1982 • 141 citations

Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man.

1983 • 138 citations

Histamine stimulates prostacyclin synthesis in cultured human umbilical vein endothelial cells

1980 • 114 citations

Paradoxical endogenous synthesis of a coronary dilating substance from arachidonate

1976 • 110 citations

In vitro studies of thromboresistance: the role of prostacyclin (PGI2) in platelet adhesion to cultured normal and virally transformed human vascular endothelial cells.

1980 • 99 citations

High affinity esterification of eicosanoid precursor fatty acids by platelets.

1983 • 95 citations

Is prostacyclin a physiologically important circulating anti-platelet agent?

1980 • 88 citations

Antibodies which antagonise the effects of prostacyclin

1978 • 70 citations

Enrichment of human platelet phospholipids with linoleic acid diminishes thromboxane release

1982 • 67 citations

Effect of aspirin on prevention of coronary and cerebrovascular disease in patients with rheumatoid arthritis. A long-term follow-up study.

1978 • 61 citations

Incidence of myocardial infarction in patients with rheumatoid arthritis

1974 • 42 citations

PGI2-specific antibodies administered suggest against a role for endogenous PGI2 as a circulating vasodepressor hormone in the normotensive and spontaneously hypertensive rat

1980 • 21 citations

Biology and biochemistry of thromboxane synthetase inhibitors.

1983 • 15 citations

Uptake and release of arachidonate by platelets.

1983 • 15 citations