An evolutionary perspective on synonymous codon usage in unicellular organisms

The Neutral Theory of Molecular Evolution

1979 • 7,965 citations

The Neutral Theory of Molecular Evolution

1983 • 6,141 citations

Non-Darwinian Evolution

1969 • 1,731 citations

Codon usage and tRNA content in unicellular and multicellular organisms.

1985 • 1,724 citations

Codon selection in yeast.

1982 • 1,580 citations

Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: A proposal for a synonymous codon choice that is optimal for the E. coli translational system

1981 • 1,405 citations

Codon usage in bacteria: correlation with gene expressivity

1982 • 1,227 citations

Codon usage in yeast: cluster analysis clearly differentiates highly and lowly expressed genes

1986 • 1,148 citations

A new method for estimating synonymous and nonsynonymous rates of nucleotide substitution considering the relative likelihood of nucleotide and codon changes.

1985 • 1,064 citations

Codon catalog usage is a genome strategy modulated for gene expressivity

1981 • 951 citations

The Mosaic Genome of Warm-Blooded Vertebrates

1985 • 887 citations

Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes

1981 • 858 citations

Preferential codon usage in prokaryotic genes: the optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genes

1982 • 850 citations

The relationship between base composition and codon usage in bacterial genes and its use for the simple and reliable identification of protein-coding sequences

1984 • 820 citations

Codon catalog usage and the genome hypothesis

1980 • 772 citations

Correlation between the abundance of yeast transfer RNAs and the occurrence of the respective codons in protein genes

1982 • 604 citations

Codon usage in regulatory genes inEscherichia colidoes not reflect selection for ‘rare’ codons

1986 • 539 citations

The codon preference plot: graphic analysis of protein coding sequences and prediction of gene expression

1984 • 381 citations

Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications

1984 • 369 citations

Genetic variability maintained in a finite population due to mutational production of neutral and nearly neutral isoalleles

1968 • 364 citations

The rate of synonymous substitution in enterobacterial genes is inversely related to codon usage bias.

1987 • 346 citations

Mechanisms of spontaneous mutagenesis: An analysis of the spectrum of spontaneous mutation in the Escherichia coli lacI gene

1986 • 305 citations

Codon usage can affect efficiency of translation of genes inEscherichia coli

1984 • 290 citations

Models of nearly neutral mutations with particular implications for nonrandom usage of synonymous codons

1987 • 271 citations

Evidence for use of rare codons in the dnaG gene and other regulatory genes of Escherichia coli.

1983 • 249 citations

Doublet frequencies in evolutionary distinct groups

1984 • 147 citations

Possibility of extensive neutral evolution under stabilizing selection with special reference to nonrandom usage of synonymous codons.

1981 • 136 citations

Evolution of DNA Sequences

1985 • 124 citations

DNA and the neutral theory

1986 • 119 citations

Codon usage and genome composition

1985 • 115 citations

Neighboring base effects on substitution rates in pseudogenes.

1986 • 105 citations

Effect of distribution of unfavourable codons on the maximum rate of gene expression by an heterologous organism

1986 • 87 citations

Codon-defined ribosomal pausing inEscherichia colidetected by using thepyrEattenuator to probe the coupling between transcription and translation

1985 • 80 citations

The A+T-rich genome of Herpesvirus saimiri contains a highly conserved gene for thymidylate synthase.

1986 • 77 citations

Markedly unbiased codon usage in Bacillus subtilis

1985 • 72 citations

Selection pressures on codon usage in the complete genome of bacteriophage T7

1985 • 69 citations

Interaction of silent and replacement changes in eukaryotic coding sequences

1985 • 44 citations

Codon usage in muscle genes and liver genes

1983 • 37 citations

Is tHere Selection Against Wobble in Codon-Anticodon Pairing?

1976 • 33 citations

Genetic Engineering of Extracellular Enzyme Systems of Bacilli

1986 • 21 citations

Analysis and comparison of the internal promoter, pE, of the ilvGMEDA operons fromEscherichia coliK-12 andSalmonella typhimurium

1986 • 17 citations

Delineation of Coding Areas in DNA Sequences Through Assignment of Codon Probabilities

1985 • 16 citations

Molecular evolution of viruses as seen by nucleic acid sequence study

1985 • 16 citations

Deleted Work

1955 • 0 citations