Intracellular Rate-Limiting Steps in MHC Class I Antigen Processing

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Empty MHC class I molecules come out in the cold

1990 • 933 citations

The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells

1998 • 890 citations

Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques.

1985 • 789 citations

Evidence that a Single Peptide–MHC Complex on a Target Cell Can Elicit a Cytolytic T Cell Response

1996 • 684 citations

Localization, Quantitation, and In Situ Detection of Specific Peptide–MHC Class I Complexes Using a Monoclonal Antibody

1997 • 679 citations

ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX

1996 • 613 citations

Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety.

1996 • 521 citations

Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules?

1996 • 440 citations

Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo.

1990 • 414 citations

Structure of vaccinia virus late promoters

1989 • 413 citations

Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen.

1988 • 331 citations

Brefeldin A Specifically Inhibits Presentation of Protein Antigens to Cytotoxic T Lymphocytes

1989 • 329 citations

Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein

1991 • 303 citations

The regulation and expression of MHC class I genes

1990 • 237 citations

Peptide antigen production by the proteasome: complexity provides efficiency

1996 • 228 citations

Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules

1995 • 225 citations

Characterization of Naturally Occurring Minor Histocompatibility Peptides Including H-4 and H-Y

1990 • 215 citations

Structure of vaccinia virus early promoters

1989 • 202 citations

Flanking sequences influence the presentation of an endogenously synthesized peptide to cytotoxic T lymphocytes.

1992 • 184 citations

Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to a yield antigenic peptides.

1994 • 172 citations

Quantitative correlation between HLA class I allele expression and recognition of melanoma cells by antigen-specific cytotoxic T lymphocytes.

1995 • 166 citations

Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to a yield antigenic peptides.

1994 • 160 citations

Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes

1992 • 155 citations

Peptide ligand-induced conformation and surface expression of the Ld class I MHC molecule

1990 • 155 citations

Regulation of LMP2 and TAP1 Genes by IRF-1 Explains the Paucity of CD8+ T Cells in IRF-1−/− Mice

1996 • 152 citations

Endogenous peptides of a soluble major histocompatibility complex class I molecule, H-2Lds: sequence motif, quantitative binding, and molecular modeling of the complex.

1992 • 146 citations

Antigen expression by dendritic cells correlates with the therapeutic effectiveness of a model recombinant poxvirus tumor vaccine

1997 • 144 citations

Rate of antigen degradation by the ubiquitin-proteasome pathway influences MHC class I presentation.

1995 • 140 citations

Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89

1988 • 128 citations

The specific binding of peptide ligand to Ld class I major histocompatibility complex molecules determines their antigenic structure.

1991 • 122 citations

Efficiency of MHC class I antigen processing: A quantitative analysis

1994 • 121 citations

The cleavage preference of the proteasome governs the yield of antigenic peptides.

1995 • 117 citations

Medullary Thymic Epithelium: A Mosaic of Epithelial “Self”?

1998 • 114 citations

Generation, intracellular transport and loading of peptides associated with MHC class I molecules

1997 • 111 citations

MHC class I-associated peptides produced from endogenous gene products with vastly different efficiencies.

1997 • 110 citations

Stress proteins and immunity mediated by cytotoxic T lymphocytes

1999 • 103 citations

Analysis of the fine specificity of rat, mouse and human TAP peptide transporters

1995 • 102 citations

Peptide selection by MHC-encoded TAP transporters

1994 • 101 citations

Deoxyribonucleic acid vaccines encoding antigens with rapid proteasome-dependent degradation are highly efficient inducers of cytolytic T lymphocytes.

1997 • 98 citations

Model for the in vivo assembly of nascent Ld class I molecules and for the expression of unfolded Ld molecules at the cell surface.

1993 • 97 citations

Influences of Transporter Associated with Antigen Processing (TAP) on the Repertoire of Peptides Associated with the Endoplasmic Reticulum–resident Stress Protein gp96

1997 • 85 citations

Role of endogenous peptides in murine allogenic cytotoxic T cell responses assessed using transfectants of the antigen-processing mutant 174xCEM.T2.

1992 • 83 citations

The three-dimensional structure of an H-2L^d-peptide complex explains the unique interaction of L^dwith beta-2 microglobulin and peptide

1997 • 83 citations

Major Histocompatibility Complex Class I Viral Antigen Processing in the Secretory Pathway Defined by the trans-Golgi Network Protease Furin

1998 • 82 citations

Slower processing, weaker beta 2-M association, and lower surface expression of H-2Ld are influenced by its amino terminus.

1986 • 69 citations

Differential presentation of the same MHC class I epitopes by fibroblasts and dendritic cells.

1998 • 66 citations

How does TAP associate with MHC class I molecules?

1997 • 62 citations

Effect of Antigen-Processing Efficiency on In Vivo T Cell Response Magnitudes

1998 • 61 citations

Protein-specific cytotoxic T lymphocytes. Recognition of transfectants expressing intracellular, membrane-associated or secreted forms of β-galactosidase

1989 • 59 citations

Specific binding of antigenic peptides to cell-associated MHC class I molecules

1991 • 57 citations

Differential Presentation of the Same MHC Class I Epitopes by Fibroblasts and Dendritic Cells

1998 • 56 citations

Selective involvement of proteasomes and cysteine proteases in MHC class I antigen presentation.

1997 • 52 citations

Proteasome activity limits the assembly of MHC class I molecules after IFN-gamma stimulation.

1997 • 46 citations

IFN-gamma is a prerequisite for optimal antigen processing of viral peptides in vivo.

1997 • 45 citations

Alloreactive CD8+ T cells can recognize unusual, rare, and unique processed peptide/MHC complexes.

1996 • 43 citations

The expression of major histocompatibility antigens under metallothionein gene promoter control.

1985 • 37 citations

Induction of peptide-specific CD8+ CTL clones in beta 2-microglobulin-deficient mice.

1995 • 30 citations

Traffic control of completely assembled MHC class I molecules beyond the endoplasmic reticulum

1997 • 29 citations

Expression levels of stress protein gp96 are not limiting for major histocompatibility complex class I‐restricted antigen presentation

1996 • 29 citations

Calnexin expression does not enhance the generation of MHC class I-peptide complexes

1998 • 26 citations

Differences among various class I molecules in competition for β2-m in vivo

1996 • 14 citations