Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation.

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals

1972 • 1,861 citations

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA

1989 • 1,280 citations

Major nucleolar proteins shuttle between nucleus and cytoplasm

1989 • 1,113 citations

Trans -Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III)

1985 • 872 citations

[71] Use of eukaryotic expression technology in the functional analysis of cloned genes

1987 • 834 citations

A novel rapid assay for chloramphenicol acetyltransferase gene expression

1987 • 802 citations

Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev function

1989 • 742 citations

Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism

1986 • 730 citations

HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA

1986 • 673 citations

A second post-transcriptional trans-activator gene required for HTLV-III replication

1986 • 639 citations

rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA.

1989 • 634 citations

Functional Organization Of The Nuclear Envelope

1988 • 593 citations

Regulation by HIV Rev depends upon recognition of splice sites

1989 • 517 citations

HIV-1 structural gene expression requires binding of the rev trans-activator to its RNA target sequence

1990 • 457 citations

HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: Implications for HIV-1 latency

1991 • 422 citations

The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization

1989 • 400 citations

Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes

1988 • 397 citations

Sequence-specific RNA binding by the HIV-1 Rev protein

1989 • 384 citations

Specific binding of HIV-1 recombinant Rev protein to the Rev-responsive element in vitro

1989 • 377 citations

HIV-1 rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA

1991 • 376 citations

Regulation of human immunodeficiency virus env expression by the rev gene product

1989 • 365 citations

The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region

1989 • 359 citations

Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae.

1991 • 359 citations

Intragenic cis-acting art gene-responsive sequences of the human immunodeficiency virus.

1988 • 355 citations

HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region

1990 • 354 citations

[25] The use of xenopus oocytes for the expression of cloned genes

1983 • 285 citations

Mutational definition of the human immunodeficiency virus type 1 Rev activation domain

1991 • 276 citations

Distinct RNA sequences in the gag region of human immunodeficiency virus type 1 decrease RNA stability and inhibit expression in the absence of Rev protein

1992 • 276 citations

Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to function

1990 • 257 citations

Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: a dual function for an arginine-rich binding motif.

1991 • 253 citations

Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: mapping cryptic functions of the arginine-rich motif.

1990 • 236 citations

Rev is necessary for translation but not cytoplasmic accumulation of HIV-1 vif, vpr, and env/vpu 2 RNAs.

1991 • 232 citations

Structural analysis of the interaction between the human immunodeficiency virus Rev protein and the Rev response element.

1991 • 226 citations

Hypusine: its post-translational formation in eukaryotic initiation factor 5A and its potential role in cellular regulation.

1993 • 219 citations

The Rev protein of human immunodeficiency virus type 1 promotes polysomal association and translation of gag/pol and vpu/env mRNAs.

1992 • 208 citations

Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent on multimer formation mediated through a basic stretch of amino acids.

1990 • 205 citations

Human immunodeficiency virus type 1 regulator of virion expression, rev, forms nucleoprotein filaments after binding to a purine-rich "bubble" located within the rev-responsive region of viral mRNAs.

1991 • 200 citations

A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus.

1992 • 198 citations

Specific binding of a basic peptide from HIV-1 Rev.

1992 • 197 citations

Secondary Structure is the Major Determinant for Interaction of HIV rev Protein with RNA

1990 • 188 citations

Site-Directed Mutagenesis of Two Trans-Regulatory Genes ( tat -III, trs ) of HIV-1

1988 • 180 citations

Identification of posttranscriptionally active inhibitory sequences in human immunodeficiency virus type 1 RNA: novel level of gene regulation

1991 • 168 citations

Specific interaction of the human immunodeficiency virus Rev protein with a structured region in the env mRNA.

1990 • 166 citations

Identification and characterization of intragenic sequences which repress human immunodeficiency virus structural gene expression

1991 • 160 citations

Identification of a high-affinity RNA-binding site for the human immunodeficiency virus type 1 Rev protein.

1992 • 159 citations

Subcellular localization of the human immunodeficiency virus trans-acting art gene product

1988 • 156 citations

Effector domains of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex are functionally interchangeable and share an essential peptide motif

1991 • 147 citations

Specific regulation of mRNA splicing in vitro by a peptide from HIV-1 Rev

1991 • 143 citations

Characterization of HIV-1 REV protein: binding stoichiometry and minimal RNA substrate

1991 • 143 citations

Cap recap: The involvement of eIF-4F in regulating gene expression

1992 • 134 citations

Identification oftrans-dominant HIV-1 rev protein mutants by direct transfer of bacterially produced proteins into human cells

1990 • 128 citations

A monoclonal antibody against a family of nuclear pore proteins (nucleoporins): O-linked N-acetylglucosamine is part of the immunodeterminant.

1987 • 123 citations

Translation Initiation Factor 5A and Its Hypusine Modification Are Essential for Cell Viability in the Yeast Saccharomyces cerevisiae

1991 • 118 citations

The art gene product of human immunodeficiency virus is required for replication

1988 • 107 citations

Interleukin 4 promotes expression of mast cell ICAM-1 antigen.

1991 • 107 citations

Identification of four nuclear transport signal-binding proteins that interact with diverse transport signals.

1989 • 101 citations

Sequence Determination and cDNA Cloning of Eukaryotic Initiation Factor 4D, the Hypusine-containing Protein

1989 • 98 citations

The essential role of hypusine in eukaryotic translation initiation factor 4D (eIF-4D)

1989 • 92 citations

The Rev Protein of Human Immunodeficiency Virus Type 1 Promotes Polysomal Association and Translation of gag/pol and vpu/env mRNAs

1992 • 89 citations

Phosphorylation of the rev gene product of human immunodeficiency virus type 1

1988 • 88 citations

Protein synthesis initiation factor eIF-4D

1989 • 81 citations

Functional mapping of the human immunodeficiency virus type 1 Rev RNA binding domain: new insights into the domain structure of Rev and Rex

1991 • 79 citations

Mutants in a conserved region near the carboxy-terminus of HIV-1 Rev identify functionally important residues and exhibit a dominant negative phenotype

1990 • 78 citations

Comparison of the activities of variant forms of eIF-4D. The requirement for hypusine or deoxyhypusine

1991 • 76 citations

Definition of the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex protein activation domain by functional exchange

1992 • 75 citations

The HIV-1 Rev protein: a model system for coupled RNA transport and translation.

1991 • 69 citations

The human immunodeficiency virus rev protein is a nuclear phosphoprotein

1989 • 61 citations

Trans-activating rev protein of the human immunodeficiency virus 1 interacts directly and specifically with its target RNA.

1990 • 59 citations

Differential expression of genes encoding the hypusine-containing translation initiation factor, elF-5A, in tobacco

1992 • 56 citations

Identification of Four Nuclear Transport Signal-Binding Proteins That Interact with Diverse Transport Signals

1989 • 45 citations

The role of mammalian initiation factor eIF-4D and its hypusine modification in translation

1990 • 41 citations

Eukaryotic initiation factor 4D. Purification from human red blood cells and the sequence of amino acids around its single hypusine residue.

1986 • 37 citations

MATRIX-BOUND ANTIGENS AND ANTIBODIES

1978 • 22 citations

Two isoforms of eIF-5A in chick embryo. Isolation, activity, and comparison of sequences of the hypusine-containing proteins.

1992 • 14 citations

ORGANIZATION OF THE AKR Qa REGION: STRUCTURE OF A DIVERGENT CLASS I SEQUENCE, Q5^k

1989 • 12 citations

Marked enhancement in vivo of adjuvant activity of muramyl dipeptide to protein antigens and to synthetic weak immunogens with monoclonal anti-muramyl dipeptide antibodies

1985 • 12 citations