19-nor Vitamin-D Analogs: A New Class of Potent Inhibitors of Proliferation and Inducers of Differentiation of Human Myeloid Leukemia Cell Lines

NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)

1991 • 884 citations

13-cis-Retinoic Acid in the Treatment of Oral Leukoplakia

1986 • 825 citations

Acute Promyelocytic Leukemia

2015 • 764 citations

Normal functional characteristics of cultured human promyelocytic leukemia cells (HL-60) after induction of differentiation by dimethylsulfoxide.

1979 • 602 citations

Antiproliferative effects of 1,25-dihydroxyvitamin D3 on primary cultures of human prostatic cells.

1994 • 489 citations

Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells.

1996 • 300 citations

Establishment of a human acute myeloid leukemia cell line (Kasumi-1) with 8;21 chromosome translocation

1991 • 288 citations

1,25-Dihydroxyvitamin D3: in vivo and in vitro effects on human preleukemic and leukemic cells.

1985 • 275 citations

p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation.

1995 • 264 citations

p27Kip1 overexpression causes apoptotic death of mammalian cells

1997 • 228 citations

Actions of vitamin D3, analogs on human prostate cancer cell lines: comparison with 1,25-dihydroxyvitamin D3.

1995 • 206 citations

Vitamin D compounds. Effect on clonal proliferation and differentiation of human myeloid cells.

1986 • 193 citations

20-epi-vitamin D3 analogues: a novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cell lines.

1995 • 188 citations

1,25-Dihydroxy-16-ene-23-yne-vitamin D3 prolongs survival time of leukemic mice.

1990 • 167 citations

1 alpha,25-Dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (Ro24-5531), a new deltanoid (vitamin D analogue) for prevention of breast cancer in the rat.

1994 • 140 citations

Novel vitamin D analogs that modulate leukemic cell growth and differentiation with little effect on either intestinal calcium absorption or bone mobilization

1989 • 133 citations

Growth inhibition of HT-29 human colon cancer cells by analogues of 1,25-dihydroxyvitamin D3.

1994 • 127 citations

Combination of a potent 20-epi-vitamin D3 analogue (KH 1060) with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells.

1996 • 118 citations

Effects of a new synthetic vitamin D analogue, EB1089, on the oestrogen-responsive growth of human breast cancer cells

1994 • 116 citations

Structure-function studies on analogues of 1 alpha,25-dihydroxyvitamin D3: differential effects on leukemic cell growth, differentiation, and intestinal calcium absorption.

1990 • 99 citations

Induction of glioma cell death by 1,25 (OH)₂ vitamin D₃: Towards an endocrine therapy of brain tumors?

1994 • 92 citations

Central effects of growth hormone-releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin action

1995 • 88 citations

1 alpha,25-Dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol, a noncalcemic analogue of 1 alpha,25-dihydroxyvitamin D3, inhibits azoxymethane-induced colonic tumorigenesis.

1995 • 77 citations

Synergistic decrease of clonal proliferation, induction of differentiation, and apoptosis of acute promyelocytic leukemia cells after combined treatment with novel 20-epi vitamin D3 analogs and 9-cis retinoic acid.

1997 • 63 citations

1,25(OH)2-16ENE-vitamin D3 is a potent antileukemic agent with low potential to cause hypercalcemia

1994 • 61 citations

Retinoic acid-resistant HL-60 cells exclusively contain mutant retinoic acid receptor-alpha

1994 • 55 citations

Control of proliferating potential of myeloid leukemia cells during long-term treatment with vitamin D3 analogues and other differentiation inducers in combination with antileukemic drugs: in vitro and in vivo studies.

1987 • 54 citations

19-nor-hexafluoride analogue of vitamin D3: a novel class of potent inhibitors of proliferation of human breast cell lines.

1997 • 43 citations

Inhibition of breast and ovarian carcinoma cell growth by 1,25-dihydroxyvitamin D3 combined with retinoic acid or dexamethasone

1995 • 41 citations

Vitamin D analogs: new therapeutic agents for the treatment of squamous cancer and its associated hypercalcemia.

1995 • 38 citations

Vitamin D analogs

1995 • 35 citations

The antiproliferative effect of vitamin D analogs on MCF-7 human breast cancer cells

1995 • 32 citations

Molecular analysis of myeloperoxidase deficiency shows heterogeneous patterns of the complete deficiency state manifested at the genomic, mRNA, and protein levels

1993 • 32 citations

Transition to tetraploidy in 1,25-dihydroxyvitamin D3-resistant HL60 cells is preceded by reduced growth factor dependence and constitutive up-regulation of Sp1 and AP-1 transcription factors.

1996 • 28 citations

Potentiation by 1-α,25-0ihydroxyvitamin D3 of Cytotoxicity to HL-60 Cells Produced by Cytarabine and Hydroxyurea

1986 • 27 citations

Effects of 1,25-Dihydroxy Vitamin D3 on All-Trans Retinoic Acid Sensitive and Resistant Acute Promyelocytic Leukemia Cells

1996 • 18 citations