Animal Behavior Models in the Analysis and Understanding of Anxiolytic Drugs Acting at Serotonin Receptors

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

1985 • 5,596 citations

Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat

1986 • 1,509 citations

Ethologically-based animal models of anxiety disorders

1990 • 841 citations

A simple and reliable conflict procedure for testing anti-anxiety agents

1971 • 832 citations

The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rat

1960 • 785 citations

Exploratory behavior models of anxiety in mice

1985 • 730 citations

Exploration of mice in a black and white test box: Validation as a model of anxiety

1989 • 535 citations

Serotonin function in anxiety

1987 • 467 citations

Animal models for the study of anti-anxiety agents: A review

1985 • 457 citations

Advances in Behavioral Pharmacology

2014 • 364 citations

The potential anxiolytic activity of GR38032F, a 5‐HT₃‐receptor antagonist

1988 • 332 citations

Buspirone

1986 • 330 citations

Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists

1989 • 285 citations

Behavioral Pharmacology: The Current Status

1985 • 281 citations

Animal models of anxiety: the effect of compounds that modify 5-HT neurotransmission

1987 • 280 citations

Effects of 5-HT1A receptor agonists and NMDA receptor antagonists in the social interaction test and the elevated plus maze

1989 • 228 citations

Anticonflict effect of the putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)

1984 • 221 citations

Behavioural Pharmacology of 5-HT

1990 • 203 citations

An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone

1989 • 192 citations

Behavioral analogues of anxiety animal models

1983 • 180 citations

Distress vocalization in rat pups a simple screening method for anxiolytic drugs

1985 • 177 citations

Zacopride: anxiolytic profile in rodent and primate models of anxiety

1988 • 170 citations

Behavioural Pharmacology of 5-HT

1989 • 158 citations

Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptors

1987 • 157 citations

Behavioral and 5-HT antagonist effects of ritanserin: A pure and selective antagonist of LSD discrimination in rat

1985 • 143 citations

Disinhibitory effects of buspirone and low doses of sulpiride and haloperidol in two experimental anxiety models in rats: Possible role of dopamine

1986 • 143 citations

Animal Models for Predicting Clinical Efficacy of Anxiolytic Drugs: Social Behaviour

1985 • 142 citations

The primate locus coeruleus and effects of clonidine on opiate withdrawal.

1982 • 137 citations

Neuropharmacological and physiological validation of a computer-controlled two-compartment black and white box for the assessment of anxiety

1989 • 136 citations

Animal Models for Anxiety and Response to Serotonergic Drugs

1989 • 135 citations

Pharmacological Characterisation of a Modified Social Interaction Model of Anxiety in the Rat

1985 • 132 citations

Recent developments in 5HT-related pharmacology of animal models of anxiety

1986 • 127 citations

Intra-hippocampal buspirone in animal models of anxiety

1989 • 124 citations

Pharmacological validation of a novel animal model of anticipatory anxiety in mice

1990 • 120 citations

Behavioral and neurochemical studies on the anticonflict actions of buspirone

1984 • 119 citations

Characterization of MDL 73005EF as a 5‐HT_1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8‐OH‐DPAT and diazepam

1990 • 113 citations

Novel non-benzodiazepine anxiolytics

1983 • 109 citations

Lack of effects of 5HT3 receptor antagonists in the social interaction and elevated plus-maze tests of anxiety in the rat

1989 • 109 citations

Effects of 5-HT1A receptor agonists and L-5-HTP in Montgomery's conflict test

1989 • 108 citations

Potential anxiolytic properties of 8-hydroxy-2-(Di-N-propylamino)tetralin, a selective serotonin1A receptor agonist

1988 • 105 citations

Behavioral effects of nonbenzodiazepine anxiolytic drugs: a comparison of CGS 9896 and zopiclone with chlordiazepoxide.

1985 • 104 citations

Behavioral studies with anxiolytic drugs. VI. Effects on punished responding of drugs interacting with serotonin receptor subtypes.

1989 • 99 citations

Serotonin does not mediate anxiolytic effects of buspirone in the fear-potentiated startle paradigm: comparison with 8-OH-DPAT and ipsapirone

1988 • 95 citations

α2-adrenoceptor antagonist activity may account for the effects of buspirone in an anticonflict test in the rat

1988 • 87 citations

Pharmacological properties of SM-3997: A new anxioselective anxiolytic candidate.

1987 • 86 citations

Blockade of potentiated startle responding in rats by 5-hydroxytryptamine1A receptor ligands

1988 • 86 citations

A comparison of anxiolytic and nonanxiolytic agents in the shock-probe/burying test for anxiolytics

1990 • 85 citations

Behavioral studies with anxiolytic drugs. III. Antipunishment actions of buspirone in the pigeon do not involve benzodiazepine receptor mechanisms.

1986 • 81 citations

Evidence that central 5‐hydroxytryptaminergic neurones are involved in the anxiolytic activity of buspirone

1989 • 79 citations

‘Taming’ of wild rats (Rattus rattus) by 5HT1A agonists buspirone and gepirone

1988 • 79 citations

The effects of 5-HT1B characterizing agents in the mouse elevated plus-maze

1990 • 78 citations

Buspirone effects in an animal conflict procedure: Comparison with diazepam and phenobarbital

1987 • 76 citations

Punishment of saccharin drinking by amphetamine in rats and its reversal by chlordiazepoxide.

1973 • 76 citations

Effects of serotonin receptor antagonists on PAG stimulation induced aversion: different contributions of 5HT1, 5HT2 and 5HT3 receptors

1989 • 74 citations

Potential use of drugs modulating 5HT activity in the treatment of anxiety

1988 • 73 citations

A comparison of buspirone and chlordiazepoxide in the shock-probe/burying test for anxiolytics

1988 • 72 citations

Effects of drugs on punished behavior: Pre-clinical test for anxiolytics

1990 • 71 citations

Actions of Buspirone in a Putative Model of Anxiety in the Mouse

1988 • 68 citations

The shock probe conflict procedure. A new assay responsive to benzodiazepines, barbiturates and related compounds

1986 • 67 citations

Behavioral studies with anxiolytic drugs. V. Behavioral and in vivo neurochemical analyses in pigeons of drugs that increase punished responding.

1988 • 66 citations

Buspirone enhances [3H]flunitrazepam binding in vivo

1983 • 65 citations

Behavioral effects of several new anxiolytics and putative anxiolytics

1987 • 57 citations

Opposite control mediated by central 5-HT1A and non-5-HT1A (5-HT1B or 5-HT1C) receptors on periaqueductal gray aversion

1989 • 54 citations

Anti-conflict efficacy of buspirone following acute versus chronic treatment

1989 • 54 citations

Conditioned defensive burying as a model for identifying anxiolytics

1988 • 54 citations

5-HT1C receptors in the serotonergic control of periaqueductal gray induced aversion in rats

1990 • 53 citations

The discriminative stimulus produced by pentylenetetrazol: effects of systemic anxiolytics and anxiogenics, aggressive defeat and midazolam or muscimol infused into the amygdala

1988 • 52 citations

β-Carbolines with agonistic and inverse agonistic properties at benzodiazepine receptors of the rat

1984 • 51 citations

Evidence for the involvement of the 5-HT1A receptor in the anxiolytic action of indorenate and ipsapirone

1990 • 48 citations

Interaction of buspirone and dopaminergic agents on punished behavior of pigeons

1986 • 48 citations

Comparative studies on the anti-punishment effects of chlordiazepoxide, buspirone and ritanserin in the pigeon, Geller-Seifter and Vogel conflict procedures

1990 • 46 citations

Effects of 8-OH-DPAT on ultrasonic vocalization and audiogenic immobility reaction in pre-weanling rats

1988 • 46 citations

Generalization of the discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and ipsapirone to yohimbine

1988 • 46 citations

Effects of buspirone in the geller‐seifter conflict test with incremental shock

1990 • 43 citations

Psychopharmacology of ritanserin: Comparison with chlordiazepoxide

1989 • 36 citations

Anticonflict effects of the 5-HT1A compound flesinoxan

1989 • 34 citations

The effect of antidepressants on aversive periaqueductal gray stimulation in rats

1990 • 33 citations

Effect of azelastine on platelet-activating factor and antigen-induced pleurisy in rats

1991 • 32 citations

Two tests in rats for antianxiety effect of clinically anxiety attenuating antidepressants

1987 • 31 citations

Rat pup isolation distress and the brain benzodiaze pine receptor

1989 • 30 citations

Behavioral analysis of the effects of benzodiazepine receptor ligands in the conditioned burying paradigm

1990 • 29 citations

Behavioral effects of acute and chronic buspirone

1988 • 29 citations

5-HT1A agonist effects on punished responding of squirrel monkeys

1990 • 26 citations

Comparison of effects of buspirone and gepirone with benzodiazepines and antagonists of dopamine and serotonin receptors on punished behavior of rats

1990 • 26 citations

Behavioural effects in gerbils of the 5-HT3 receptor antagonists, BRL 43694 and ICS 205-930, under circumstances of high and low light intensity

1990 • 25 citations

Anxiolytic profile of GR 38032F in the potentiated startle paradigm

1989 • 24 citations

Yohimbine and serotonergic agonists: Stimulus properties and receptor binding

1989 • 20 citations

The 5-HT3 receptor antagonists ICS 205-930 and GR38032F, putative anxiolytic drugs, differ from diazepam in their pharmacological profile

1989 • 20 citations

Effects of serotonin receptor antagonists on punished responding maintained by stimulus-shock termination or food presentation in squirrel monkeys.

1985 • 18 citations

Drug discrimination in pentylenetetrazol‐trained baboons: Generalization to buspirone and β‐carboline‐3‐carboxylic acid ethyl ester but not lorazepam or pentobarbital

1989 • 17 citations

Use of conditioned taste aversion as a conflict model: effects of anxiolytic drugs.

1988 • 17 citations

Anticonflict effect of ipsapirone, buspirone and gepirone is not mediated by their common metabolite 1-(2-pyrimidinyl)piperazine

1989 • 16 citations

Buspirone antagonizes the expression of conditioned taste aversion in rats

1987 • 12 citations

Deleted Work

1955 • 0 citations