Gating of voltage-dependent potassium channels

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

The Structure of the Potassium Channel: Molecular Basis of K ⁺ Conduction and Selectivity

1998 • 6,595 citations

Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp

1996 • 2,561 citations

Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation

1990 • 1,528 citations

The components of membrane conductance in the giant axon of Loligo

1952 • 1,359 citations

Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence

1984 • 1,339 citations

Structural parts involved in activation and inactivation of the sodium channel

1989 • 1,189 citations

Structure and Function of Voltage-Sensitive Ion Channels

1988 • 1,171 citations

Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons

1971 • 930 citations

Determination of the subunit stoichiometry of a voltage-activated potassium channel

1991 • 925 citations

The Voltage Sensor in Voltage-Dependent Ion Channels

2000 • 854 citations

The role of the leucine zipper in the fos–jun interaction

1988 • 836 citations

Cloning of Genomic and Complementary DNA from Shaker , a Putative Potassium Channel Gene from Drosophila

1987 • 721 citations

Contribution of the S4 Segment to Gating Charge in the Shaker K+ Channel

1996 • 678 citations

Acetylcholine Receptor Channel Structure Probed in Cysteine-Substitution Mutants

1992 • 668 citations

Currents Related to Movement of the Gating Particles of the Sodium Channels

1973 • 664 citations

Voltage-Sensing Residues in the S2 and S4 Segments of the Shaker K+ Channel

1996 • 654 citations

Sequence of a Probable Potassium Channel Component Encoded at Shaker Locus of Drosophila

1987 • 645 citations

Mutations Affecting Internal TEA Blockade Identify the Probable Pore-Forming Region of a K ⁺ Channel

1991 • 634 citations

Direct Physical Measure of Conformational Rearrangement Underlying Potassium Channel Gating

1996 • 598 citations

Structural Rearrangements Underlying K ⁺ -Channel Activation Gating

1999 • 553 citations

Shaker potassium channel gating. III: Evaluation of kinetic models for activation.

1994 • 512 citations

Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence

1991 • 507 citations

Transmembrane Movement of the Shaker K+ Channel S4

1996 • 496 citations

Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy

1999 • 466 citations

The Size of Gating Charge in Wild-Type and Mutant Shaker Potassium Channels

1992 • 422 citations

Voltage gating of ion channels

1994 • 405 citations

Gating currents and charge movements in excitable membranes

2006 • 405 citations

Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes

1988 • 396 citations

Presynaptic A-current based on heteromultimeric K+ channels detected in vivo

1993 • 379 citations

Potassium Ion Current in the Squid Giant Axon

1960 • 375 citations

Electrostatic interactions of S4 voltage sensor in shaker K+ channel

1995 • 366 citations

Atomic scale structure and functional models of voltage-gated potassium channels

1992 • 332 citations

Characterizing Voltage-Dependent Conformational Changes in the K Channel with Fluorescence

1997 • 329 citations

Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channels

1993 • 317 citations

Shaker potassium channel gating. II: Transitions in the activation pathway.

1994 • 299 citations

Three-dimensional architecture and gating mechanism of a K+ channel studied by EPR spectroscopy

1998 • 297 citations

Luminescence energy transfer using a terbium chelate: improvements on fluorescence energy transfer.

1994 • 290 citations

The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation

1989 • 286 citations

Activation of Shaker Potassium Channels

1998 • 277 citations

Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel

1999 • 276 citations

Voltage-dependent gating of Shaker A-type potassium channels in Drosophila muscle.

1990 • 276 citations

Voltage-sensing residues in the S4 region of a mammalian K+ channel

1991 • 275 citations

Gating of Shaker K+ channels: II. The components of gating currents and a model of channel activation

1994 • 275 citations

Mutations in the S4 Region Isolate the Final Voltage-dependent Cooperative Step in Potassium Channel Activation

1999 • 238 citations

pH-Dependent Gating in the Streptomyces lividans K⁺ Channel

1998 • 237 citations

Activation of Shaker Potassium Channels

1998 • 227 citations

Voltage-Dependent Proton Transport by the Voltage Sensor of the Shaker K+ Channel

1997 • 224 citations

Molecular Basis of Gating Charge Immobilization in Shaker Potassium Channels

1991 • 218 citations

Electrostatic interactions between transmembrane segments mediate folding of Shaker K+ channel subunits

1997 • 207 citations

Divalent cations and the activation kinetics of potassium channels in squid giant axons.

1982 • 205 citations

A role for hydrophobic residues in the voltage-dependent gating of Shaker K+ channels.

1991 • 204 citations

Voltage clamp analysis of membrane currents in larval muscle fibers of Drosophila: alteration of potassium currents in Shaker mutants

1985 • 194 citations

Shaker potassium channel gating. I: Transitions near the open state.

1994 • 187 citations

Three Transmembrane Conformations and Sequence-Dependent Displacement of the S4 Domain in Shaker K + Channel Gating

1998 • 172 citations

Uncharged S4 Residues and Cooperativity in Voltage-dependent Potassium Channel Activation

1998 • 160 citations

Evidence for cooperative interactions in potassium channel gating

1992 • 144 citations

Incremental reductions of positive charge within the S4 region of a voltage-gated K+ channel result in corresponding decreases in gating charge

1992 • 142 citations

Role of the S4 in Cooperativity of Voltage-dependent Potassium Channel Activation

1998 • 141 citations

Spin-label study of hemoglobin conformations in solution.

1967 • 140 citations

Helical Structure and Packing Orientation of the S2 Segment in the Shaker K+ Channel

1999 • 132 citations

S4 mutations alter gating currents of Shaker K channels

1994 • 132 citations

Gating mechanism of a cloned potassium channel expressed in frog oocytes and mammalian cells

1990 • 132 citations

Voltage-Dependent Structural Interactions in the Shaker K+ Channel

2000 • 131 citations

Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel

1996 • 129 citations

Some kinetic and steady-state properties of sodium channels after removal of inactivation.

1981 • 121 citations

Total Charge Movement per Channel

1997 • 120 citations

A Localized Interaction Surface for Voltage-Sensing Domains on the Pore Domain of a K+ Channel

2000 • 117 citations

A characterization of the activating structural rearrangements in voltage-dependent Shaker K+ channels

1994 • 112 citations

Effective gating charges per channel in voltage-dependent K+ and Ca2+ channels.

1996 • 111 citations

N-type inactivation and the S4-S5 region of the Shaker K+ channel.

1996 • 107 citations

Activation of squid axon K+ channels. Ionic and gating current studies.

1985 • 101 citations

Potassium Channels

1999 • 83 citations

Molecular basis of altered excitability in Shaker mutants of Drosophila melanogaster.

1990 • 79 citations

Activation of Shaker Potassium Channels

1998 • 73 citations

Role of Transmembrane Segment S5 on Gating of Voltage-dependent K+ Channels

1997 • 67 citations

Allosteric Effects of Permeating Cations on Gating Currents during K+ Channel Deactivation

1997 • 60 citations

Determinants of Voltage-Dependent Gating and Open-State Stability in the S5 Segment of Shaker Potassium Channels

1999 • 43 citations

High-Level Expression and Functional Reconstitution of Shaker K+ Channels

1994 • 35 citations

Alteration of potassium channel gating: Molecular analysis of the drosophila Sh5 mutation

1990 • 31 citations

Alterations in activation gating of single Shaker A-type potassium channels by the Sh5 mutation

1990 • 30 citations

S4 mutations alter the single-channel gating kinetics of Shaker K+ channels

1993 • 28 citations

Sequential gating in the human heart K⁺ channel Kv1.5 incorporatesQ ₁ andQ ₂ charge components

1999 • 14 citations

Boring and crazing

1989 • 1 citations