N-type inactivation and the S4-S5 region of the Shaker K+ channel.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation

1990 • 1,528 citations

Inactivation of the sodium channel. I. Sodium current experiments.

1977 • 1,509 citations

Inactivation of the sodium channel. II. Gating current experiments.

1977 • 943 citations

Restoration of Inactivation in Mutants of Shaker Potassium Channels by a Peptide Derived from ShB

1990 • 752 citations

Acetylcholine Receptor Channel Structure Probed in Cysteine-Substitution Mutants

1992 • 668 citations

[6] Efficient site-directed mutagenesis using uracil-containing DNA

1991 • 644 citations

Molecular Basis of Charge Movement in Voltage-Gated Sodium Channels

1996 • 603 citations

Direct Physical Measure of Conformational Rearrangement Underlying Potassium Channel Gating

1996 • 598 citations

Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels.

1993 • 582 citations

Transmembrane Movement of the Shaker K+ Channel S4

1996 • 496 citations

Dynamic Rearrangement of the Outer Mouth of a K+ Channel during Gating

1996 • 451 citations

Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels.

1991 • 434 citations

Ionic pores, gates, and gating currents

1974 • 358 citations

Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel

1991 • 341 citations

Multiple products of the drosophila Shaker gene may contribute to potassium channel diversity

1988 • 324 citations

Simple alkanethiol groups for temporary blocking of sulfhydryl groups of enzymes

1975 • 311 citations

The inactivation gate of the Shaker K+ channel behaves like an open-channel blocker

1991 • 308 citations

The internal quaternary ammonium receptor site of Shaker potassium channels

1993 • 273 citations

Electrostatic potential of the acetylcholine binding sites in the nicotinic receptor probed by reactions of binding-site cysteines with charged methanethiosulfonates

1994 • 255 citations

A role for hydrophobic residues in the voltage-dependent gating of Shaker K+ channels.

1991 • 204 citations

Functional Stoichiometry of Shaker Potassium Channel Inactivation

1993 • 186 citations

Silver as a Probe of Pore-Forming Residues in a Potassium Channel

1995 • 182 citations

Identification of a translocated protein segment in a voltage-dependent channel

1994 • 158 citations

Interactions of amino terminal domains of Shaker K channels with a pore blocking site studied with synthetic peptides.

1993 • 148 citations

Structure of a bacterial sensory receptor. A site-directed sulfhydryl study.

1988 • 131 citations

Exposure of Residues in the Cyclic Nucleotide–Gated Channel Pore: P Region Structure and Function in Gating

1996 • 118 citations

K+ pore structure revealed by reporter cysteines at inner and outer surfaces

1995 • 112 citations

Energetics of Shaker K channels block by inactivation peptides.

1993 • 108 citations

Side-chain accessibilities in the pore of a K+ channel probed by sulfhydryl-specific reagents after cysteine-scanning mutagenesis

1995 • 101 citations

A method for the rapid exchange of solutions bathing excised membrane patches

1986 • 87 citations