Voltage-Sensing Residues in the S2 and S4 Segments of the Shaker K+ Channel

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

1989 • 3,067 citations

Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation

1990 • 1,528 citations

Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence

1984 • 1,339 citations

Structural parts involved in activation and inactivation of the sodium channel

1989 • 1,189 citations

Determination of the subunit stoichiometry of a voltage-activated potassium channel

1991 • 925 citations

The variance of sodium current fluctuations at the node of Ranvier

1980 • 772 citations

Currents Related to Movement of the Gating Particles of the Sodium Channels

1973 • 664 citations

Molecular Basis of Charge Movement in Voltage-Gated Sodium Channels

1996 • 603 citations

Direct Physical Measure of Conformational Rearrangement Underlying Potassium Channel Gating

1996 • 598 citations

MOLECULAR PROPERTIES OF VOLTAGE-SENSITIVE SODIUM CHANNELS

1986 • 577 citations

Molecular model of the action potential sodium channel.

1986 • 525 citations

Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence

1991 • 507 citations

Transmembrane Movement of the Shaker K+ Channel S4

1996 • 496 citations

Multiple potassium–channel components are produced by alternative splicing at the Shaker locus in Drosophila

1988 • 495 citations

The Size of Gating Charge in Wild-Type and Mutant Shaker Potassium Channels

1992 • 422 citations

Gating currents and charge movements in excitable membranes

2006 • 405 citations

Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes

1988 • 396 citations

Evidence for voltage-dependent S4 movement in sodium channels

1995 • 396 citations

Electrostatic interactions of S4 voltage sensor in shaker K+ channel

1995 • 366 citations

Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channels

1993 • 317 citations

Voltage-sensing residues in the S4 region of a mammalian K+ channel

1991 • 275 citations

Gating of Shaker K+ channels: II. The components of gating currents and a model of channel activation

1994 • 275 citations

Molecular Basis of Gating Charge Immobilization in Shaker Potassium Channels

1991 • 218 citations

Gating of Shaker K+ channels: I. Ionic and gating currents

1994 • 159 citations

Incremental reductions of positive charge within the S4 region of a voltage-gated K+ channel result in corresponding decreases in gating charge

1992 • 142 citations

S4 mutations alter gating currents of Shaker K channels

1994 • 132 citations

Images of purified Shaker potassium channels

1994 • 111 citations

Mutation of conserved negatively charged residues in the S2 and S3 transmembrane segments of a mammalian K+ channel selectively modulates channel gating.

1995 • 98 citations

Gating Current Noise Produced by Elementary Transitions in Shaker Potassium Channels

1994 • 96 citations