Role of the S4 in Cooperativity of Voltage-dependent Potassium Channel Activation

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein

2014 • 5,592 citations

Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation

1990 • 1,528 citations

Primary structure of the receptor for calcium channel blockers from skeletal muscle

1987 • 1,359 citations

Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence

1984 • 1,339 citations

Structure and Function of Voltage-Sensitive Ion Channels

1988 • 1,171 citations

Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs

1992 • 1,067 citations

Voltage Dependent Charge Movement in Skeletal Muscle: a Possible Step in Excitation–Contraction Coupling

1973 • 978 citations

Determination of the subunit stoichiometry of a voltage-activated potassium channel

1991 • 925 citations

Existence of distinct sodium channel messenger RNAs in rat brain

1986 • 909 citations

Restoration of excitation—contraction coupling and slow calcium current in dysgenic muscle by dihydropyridine receptor complementary DNA

1988 • 803 citations

Restoration of Inactivation in Mutants of Shaker Potassium Channels by a Peptide Derived from ShB

1990 • 752 citations

Charge Movement Associated with the Opening and Closing of the Activation Gates of the Na Channels

1974 • 746 citations

Cloning of Genomic and Complementary DNA from Shaker , a Putative Potassium Channel Gene from Drosophila

1987 • 721 citations

Two types of inactivation in Shaker K+ channels: Effects of alterations in the carboxy-terminal region

1991 • 688 citations

Contribution of the S4 Segment to Gating Charge in the Shaker K+ Channel

1996 • 678 citations

Voltage-Sensing Residues in the S2 and S4 Segments of the Shaker K+ Channel

1996 • 654 citations

The Use ofXenopusOocytes for the Study of Ion Channel

1987 • 649 citations

Sequence of a Probable Potassium Channel Component Encoded at Shaker Locus of Drosophila

1987 • 645 citations

Regions of the skeletal muscle dihydropyridine receptor critical for excitation–contraction coupling

1990 • 606 citations

Molecular Basis of Charge Movement in Voltage-Gated Sodium Channels

1996 • 603 citations

Direct Physical Measure of Conformational Rearrangement Underlying Potassium Channel Gating

1996 • 598 citations

Sequence and Expression of mRNAs Encoding the α ₁ and α ₂ Subunits of a DHP-Sensitive Calcium Channel

1988 • 579 citations

Shaker potassium channel gating. III: Evaluation of kinetic models for activation.

1994 • 512 citations

Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence

1991 • 507 citations

Transmembrane Movement of the Shaker K+ Channel S4

1996 • 496 citations

Multiple potassium–channel components are produced by alternative splicing at the Shaker locus in Drosophila

1988 • 495 citations

The aromatic binding site for tetraethylammonium ion on potassium channels

1992 • 446 citations

Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila.

1988 • 443 citations

The Size of Gating Charge in Wild-Type and Mutant Shaker Potassium Channels

1992 • 422 citations

Kinetics and steady‐state properties of the charged system controlling sodium conductance in the squid giant axon

1974 • 420 citations

Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel

1987 • 412 citations

Gating currents and charge movements in excitable membranes

2006 • 405 citations

Voltage gating of ion channels

1994 • 405 citations

Evidence for voltage-dependent S4 movement in sodium channels

1995 • 396 citations

Electrostatic interactions of S4 voltage sensor in shaker K+ channel

1995 • 366 citations

A rat brain na+ channel α subunit with novel gating properties

1988 • 359 citations

Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel

1991 • 341 citations

Primary structure of rat brain sodium channel III deduced from the cDNA sequence

1988 • 334 citations

Atomic scale structure and functional models of voltage-gated potassium channels

1992 • 332 citations

Multiple products of the drosophila Shaker gene may contribute to potassium channel diversity

1988 • 324 citations

K ⁺ Current Diversity Is Produced by an Extended Gene Family Conserved in Drosophila and Mouse

1990 • 323 citations

Cloning of a probable potassium channel gene from mouse brain

1988 • 304 citations

Shaker potassium channel gating. II: Transitions in the activation pathway.

1994 • 299 citations

A Family of Putative Potassium Channel Genes in Drosophila

1989 • 281 citations

Voltage-sensing residues in the S4 region of a mammalian K+ channel

1991 • 275 citations

Gating of Shaker K+ channels: II. The components of gating currents and a model of channel activation

1994 • 275 citations

Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous systems.

1988 • 252 citations

Genomic Organization and Deduced Amino Acid Sequence of a Putative Sodium Channel Gene in Drosophila

1987 • 244 citations

Molecular Basis of Gating Charge Immobilization in Shaker Potassium Channels

1991 • 218 citations

Molecular determinants of voltage-dependent inactivation in calcium channels

1994 • 217 citations

Electrostatic interactions between transmembrane segments mediate folding of Shaker K+ channel subunits

1997 • 207 citations

A role for hydrophobic residues in the voltage-dependent gating of Shaker K+ channels.

1991 • 204 citations

Shaker potassium channel gating. I: Transitions near the open state.

1994 • 187 citations

Uncharged S4 Residues and Cooperativity in Voltage-dependent Potassium Channel Activation

1998 • 160 citations

Gating of Shaker K+ channels: I. Ionic and gating currents

1994 • 159 citations

Cooperative subunit interactions in C-type inactivation of K channels

1995 • 146 citations

Repeat I of the dihydropyridine receptor is critical in determining calcium channel activation kinetics

1991 • 145 citations

Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in shaker K+ channels

1991 • 145 citations

Evidence for cooperative interactions in potassium channel gating

1992 • 144 citations

Multiple subunits of a voltage-dependent potassium channel contribute to the binding site for tetraethylammonium

1992 • 142 citations

Incremental reductions of positive charge within the S4 region of a voltage-gated K+ channel result in corresponding decreases in gating charge

1992 • 142 citations

Gating of single Shaker potassium channels in Drosophila muscle and in Xenopus oocytes injected with Shaker mRNA.

1989 • 137 citations

S4 mutations alter gating currents of Shaker K channels

1994 • 132 citations

Gating mechanism of a cloned potassium channel expressed in frog oocytes and mammalian cells

1990 • 132 citations

Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel

1996 • 129 citations

Total Charge Movement per Channel

1997 • 120 citations

Critical roles of the S3 segment and S3-S4 linker of repeat I in activation of L-type calcium channels.

1994 • 114 citations

A characterization of the activating structural rearrangements in voltage-dependent Shaker K+ channels

1994 • 112 citations

Effective gating charges per channel in voltage-dependent K+ and Ca2+ channels.

1996 • 111 citations

Genetic analysis of Drosophila neurons: Shal, Shaw, and Shab encode most embryonic potassium currents

1995 • 107 citations

Molecular cloning of a member of a third class of Shaker-family K+ channel genes in mammals.

1990 • 98 citations

Mutation of conserved negatively charged residues in the S2 and S3 transmembrane segments of a mammalian K+ channel selectively modulates channel gating.

1995 • 98 citations

Gating Current Noise Produced by Elementary Transitions in Shaker Potassium Channels

1994 • 96 citations

Tandem linkage of Shaker K+ channel subunits does not ensure the stoichiometry of expressed channels

1992 • 81 citations

Molecular basis of altered excitability in Shaker mutants of Drosophila melanogaster.

1990 • 79 citations

Gating currents of inactivating and non-inactivating potassium channels expressed in Xenopus oocytes

1991 • 78 citations

Chimeric study of sodium channels from rat skeletal and cardiac muscle

1992 • 78 citations

Role of Transmembrane Segment S5 on Gating of Voltage-dependent K+ Channels

1997 • 67 citations

Role of the S3-S4 Linker in Shaker Potassium Channel Activation

1997 • 58 citations

Transfer of Voltage Independence from a Rat Olfactory Channel to the Drosophila Ether-à-go-go K+ Channel

1997 • 55 citations

Cooperative interactions among subunits of a voltage-dependent potassium channel. Evidence from expression of concatenated cDNAs.

1992 • 55 citations

Gating charge differences between two voltagegated K+ channels are due to the specific charge content of their respective S4 regions

1993 • 52 citations

Swapping of functional domains in voltage-gated K ⁺ channels

1991 • 49 citations

Alteration of potassium channel gating: Molecular analysis of the drosophila Sh5 mutation

1990 • 31 citations

Alterations in activation gating of single Shaker A-type potassium channels by the Sh5 mutation

1990 • 30 citations

A site accessible to extracellular TEA+ and K+ influences intracellular Mg2+ block of cloned potassium channels

1993 • 29 citations

Substitution of a hydrophobic residue alters the conformational stability of Shaker K+ channels during gating and assembly

1993 • 27 citations

Functional differences of a Kv2.1 channel and a Kv2.1/Kv1.2S4-chimera are confined to a concerted voltage shift of various gating parameters.

1997 • 4 citations