Age-associated decline in γ-glutamylcysteine synthetase gene expression in rats

Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol.

1996 • 911 citations

Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase.

1993 • 368 citations

Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol

1996 • 307 citations

Alterations of Antioxidant Enzymes and Oxidative Damage to Macromolecules in Different Organs of Rats During Aging

1998 • 298 citations

Reactive oxygen species and Alzheimer's disease

1997 • 228 citations

Independent Influence of Age on Basal Insulin Secretion in Nondiabetic Humans

1999 • 202 citations

Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin

1999 • 181 citations

Glucocorticoids, hippocampal corticosteroid receptor gene expression and antidepressant treatment: relationship with spatial learning in young and aged rats

1995 • 174 citations

Expression of Multidrug Resistance Protein/GS-X Pump and γ-Glutamylcysteine Synthetase Genes Is Regulated by Oxidative Stress

1998 • 166 citations

Transforming Growth Factor- β₁ Is a Potent Inhibitor of Glutathione Synthesis in the Lung Epithelial Cell Line A549: Transcriptional Effect on the GSH Rate-limiting Enzyme γ -Glutamylcysteine Synthetase

1997 • 153 citations

Increased Transcription of the Regulatory Subunit of γ-Glutamylcysteine Synthetase in Rat Lung Epithelial L2 Cells Exposed to Oxidative Stress or Glutathione Depletion

1997 • 141 citations

The induction of GSH synthesis by nanomolar concentrations of NO in endothelial cells: a role for γ‐glutamylcysteine synthetase and γ‐glutamyl transpeptidase

1999 • 135 citations

On the Cycles of Glutathione Metabolism and Transport

1981 • 120 citations

The Effect of Aging on Glutathione and Cysteine Levels in Different Regions of the Mouse Brain

1989 • 110 citations

Oxidative stress in Parkinson's disease and other neurodegenerative disorders.

1996 • 107 citations

Regulation of γ-glutamylcysteine synthetase by protein phosphorylation

1996 • 102 citations

Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat. Studies in cultured hepatocytes and in vivo.

1992 • 95 citations

γ-Glutamylcysteine synthetase: mRNA stabilization and independent subunit transcription by 4-hydroxy-2-nonenal

1998 • 95 citations

Nuclear Factor Kappa B Dependent Induction of Gamma Glutamylcysteine Synthetase by Ionizing Radiation in T98G Human Glioblastoma Cells

1998 • 91 citations

Effect of ageing on human plasma glutathione concentrations as determined by high-performance liquid chromatography with fluorimetric detection

1995 • 88 citations

Aging and glucose homeostasis in C57BL/6J male mice

1988 • 87 citations

gamma-Glutamylcysteine synthetase and GSH increase in quinone-induced oxidative stress in BPAEC

1994 • 86 citations

Effects of age on levels of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione level of mouse with cysteine derivatives

1996 • 77 citations

Increased gamma-glutamylcysteine synthetase and gamma-glutamyl transpeptidase activities enhance resistance of rat lung epithelial L2 cells to quinone toxicity.

1996 • 74 citations

Neurodegenerative mechanisms in alzheimer disease

1996 • 72 citations

Age-related cysteine uptake as rate-limiting in glutathione synthesis and glutathione half-life in the cultured human lens

1991 • 70 citations

In VivoInsulin-Dependent Glucose Uptake of Specific Tissues Is Decreased during Aging of Mature Wistar Rats¹

1997 • 70 citations

Hormonal and cell density regulation of hepatic gamma-glutamylcysteine synthetase gene expression.

1995 • 63 citations

Relationship Between Glucose Tolerance and Glucose-Stimulated Insulin Response in 65-Year-Olds

1993 • 53 citations

Age-dependent reduction in insulin secretion and insulin mRNA in isolated islets from rats

1995 • 50 citations

Age-related changes in body composition are associated with hepatic insulin resistance in conscious rats

1996 • 50 citations

Differential Effects of Aging on Adrenocdrticotropin Receptors, Adenosine 3′5′-Monophosphate Response, and Corticosterone Secretion in Adrenocortical Cells from Sprague-Dawley Rats*

1986 • 49 citations

Acetaminophen-induced depletion of glutathione and cysteine in the aging mouse kidney

1992 • 48 citations

Glutathione metabolism in heart and liver of the aging rat

1994 • 46 citations

Expression of hydrogen peroxide and glutathione metabolizing enzymes in human skin fibroblasts derived from donors of different ages

1996 • 44 citations

Age and GSH metabolism in rat cerebral cortex, as related to oxidative and energy parameters

1993 • 42 citations

Alterations in the activities of cerebral antioxidant enzymes of rat are related to aging

1997 • 41 citations

Age-related changes in antioxidant defence mechanisms and peroxidation in isolated hepatocytes from spontaneously hypertensive and normotensive rats

1994 • 39 citations

Dietary polyunsaturated fatty acids and aging modulate glutathione-related antioxidants in rat liver.

1995 • 31 citations

Metabolic Adaption of Pancreatic Islet Tissue in Aging Rats

1984 • 28 citations

In Vivo Insulin-Dependent Glucose Uptake of Specific Tissues Is Decreased during Aging of Mature Wistar Rats

1997 • 24 citations

Relationship between age and GSH metabolism in synaptosomes of rat cerebral cortex

1994 • 23 citations

Dietary Sucrose Enhances Insulin Secretion of Aging Fischer 344 Rats

1992 • 23 citations

Coincident plasma ACTH and corticosterone time series: Comparisons between young and old rats

1994 • 23 citations

The effects of age on glutathione synthesis enzymes in lenses of Old World simians and prosimians

1992 • 22 citations

Effects of Aging and Antioxidants on Glucose Transport in Rat Adipocytes

1995 • 21 citations

Independent Influence of Age on Basal Insulin Secretion in Nondiabetic Humans

1999 • 21 citations

Reduced Glucocorticoid Response to Corticotropin Secretagogues in the Aged Sprague-Dawley Rat

1995 • 18 citations

Age changes in visceral content of glutathione in the senescence accelerated mouse (SAM)

1993 • 16 citations

B cells of aging rats: Impaired stimulus-secretion coupling but normal susceptibility to adverse effects of a diabetic state

1997 • 7 citations