Structural Analyses of Human Developmentally Regulated Vh3 Genes

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

1987 • 1,436 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1988 • 1,256 citations

Multiple Point Mutations Affecting the Simian Virus 40 Enhancer

1983 • 883 citations

B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo

1985 • 859 citations

The role of the leucine zipper in the fos–jun interaction

1988 • 836 citations

The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.

1988 • 670 citations

Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements

1984 • 669 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

Development of the Primary Antibody Repertoire

1987 • 629 citations

Protein-Binding Sites in Ig Gene Enhancers Determine Transcriptional Activity and Inducibility

1987 • 619 citations

Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements

1985 • 588 citations

Early Restriction of the Human Antibody Repertoire

1987 • 546 citations

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

The immunoglobulin heavy chain variable region (Igh‐V) locus in the mouse. I. One hundred Igh‐V genes comprise seven families of homologous genes

1984 • 537 citations

Multiple sequence motifs are involved in SV40 enhancer function.

1986 • 511 citations

A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells

1988 • 494 citations

Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus.

1988 • 432 citations

The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.

1988 • 429 citations

Regulation of Genome Rearrangement Events during Lymphocyte Differentiation

1986 • 422 citations

A lymphocyte-specific enhancer in the mouse immunoglobulin κ gene

1984 • 410 citations

A human lymphoid- specific transcription factor that activates immunoglobulin genes is a homoeobox protein

1988 • 399 citations

Homeobox proteins as sequence-specific transcription factors

1988 • 397 citations

Evolutionary and Somatic Selection of the Antibody Repertoire in the Mouse

1987 • 388 citations

Developmentally Controlled Expression of Immunoglobulin V _H Genes

1985 • 349 citations

Cell-type-specific contacts to immunoglobulin enhancers in nuclei

1985 • 341 citations

Antibody diversity: Somatic hypermutation of rearranged VH genes

1981 • 334 citations

Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence

1985 • 313 citations

Two transcription factors, NF-kappa B and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter.

1988 • 308 citations

The SV40 enhancer is composed of multiple functional elements that can compensate for one another

1986 • 293 citations

Oligonucleotide that binds nuclear factor NF-kappa B acts as a lymphoid-specific and inducible enhancer element.

1988 • 275 citations

Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus

1984 • 274 citations

Alternative Mechanisms for Activation of Human Immunodeficiency Virus Enhancer in T Cells

1988 • 265 citations

Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer.

1987 • 255 citations

A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain

1988 • 234 citations

Organization and evolution of variable region genes of the human immunoglobulin heavy chain

1986 • 227 citations

Structure and chromosomal localization of the functional intronless human JUN protooncogene.

1988 • 221 citations

Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region.

1980 • 199 citations

Developmentally regulated and strain-specific expression of murine VH gene families.

1988 • 186 citations

A new human immunoglobulin VH family preferentially rearranged in immature B-cell tumours

1988 • 174 citations

A conserved sequence in the immunoglobulin Jκ–Cκ intron: possible enhancer element

1983 • 162 citations

Evolution of Antibody Variable Region Structure during the Immune Response

1987 • 149 citations

A 16/6 idiotype—positive anti‐DNA antibody is encoded by a conserved V_H gene with no somatic mutation

1988 • 132 citations

Multiple DNA sequence elements are necessary for the function of an immunoglobulin heavy chain promoter.

1987 • 123 citations

Evolutionary aspects of immunoglobulin heavy chain variable region (VH) gene subgroups.

1983 • 122 citations

The organization of the mouse Igh-V locus. Dispersion, interspersion, and the evolution of VH gene family clusters.

1988 • 116 citations

DNase I hypersensitive sites in the chromatin of human μ immunoglobulin heavy-chain genes

1983 • 110 citations

Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements.

1988 • 103 citations

Adult B-cell repertoire is biased toward two heavy-chain variable-region genes that rearrange frequently in fetal pre-B cells.

1987 • 100 citations

Origin of Immune Diversity: Genetic Variation and Selection

1985 • 99 citations

Sequences closely related to an immunoglobulin gene promoter/enhancer element occur also upstream of other eukaryotic and of prokaryotic genes

1986 • 78 citations

Structure and chromosomal localization of the function intronless human JUN protooncogene

1988 • 62 citations

In vivofunctional analysis ofin vitroprotein binding sites in the immunoglobulin heavy chain enhancer

1988 • 57 citations

A V_H gene is located within 95 Kb of the human immunoglobulin heavy chain constant region genes

1988 • 51 citations

Upstream regulatory sequences of immunoglobulin genes are recognized by nuclear proteins which also bind to other gene regions

1986 • 42 citations

Programmed Development of the Antibody Repertoire

1987 • 27 citations

Correlation between DNase I hypersensitive sites and putative regulatory sequences in human immunoglobulin genes of thexlight chain type

1984 • 21 citations

A structural basis for human cross-reacting idiotypes

1988 • 10 citations