Oncogene-specific gene expression signatures at preneoplastic stage in mice define distinct mechanisms of hepatocarcinogenesis

The Hallmarks of Cancer

2000 • 27,569 citations

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Cancer Cell Cycles

1996 • 5,379 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

Mitochondrial Diseases in Man and Mouse

1999 • 3,008 citations

c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism

1999 • 1,650 citations

Molecular pathogenesis of human hepatocellular carcinoma

2002 • 1,424 citations

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

2003 • 1,350 citations

c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth

1997 • 1,015 citations

Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling

2004 • 874 citations

TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver

2003 • 809 citations

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis

2001 • 747 citations

Liver Peroxisome Proliferator-activated Receptor γ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass

2003 • 733 citations

Drosophila myc Regulates Cellular Growth during Development

1999 • 637 citations

Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis

2001 • 587 citations

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

2004 • 573 citations

Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes

2003 • 525 citations

Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes

2003 • 509 citations

An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

2003 • 481 citations

Application of comparative functional genomics to identify best-fit mouse models to study human cancer

2004 • 461 citations

Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis

2002 • 449 citations

PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP

2005 • 424 citations

Regulation of Peroxisome Proliferator-Activated Receptor γ Expression by Adipocyte Differentiation and Determination Factor 1/Sterol Regulatory Element Binding Protein 1: Implications for Adipocyte Differentiation and Metabolism

1999 • 424 citations

Obesity and hepatocellular carcinoma

2004 • 393 citations

Proliferation, But Not Growth, Blocked by Conditional Deletion of 40 S Ribosomal Protein S6

2000 • 366 citations

c-Myc enhances protein synthesis and cell size during B lymphocyte development

1999 • 357 citations

E2Fs Regulate Adipocyte Differentiation

2002 • 310 citations

Analysis of genomic targets reveals complex functions of MYC

2004 • 296 citations

Coordinated regulation of life and death by RB

2003 • 290 citations

E2F1 and c-Myc Potentiate Apoptosis through Inhibition of NF-κB Activity that Facilitates MnSOD-Mediated ROS Elimination

2002 • 282 citations

Myc Requires Distinct E2F Activities to Induce S Phase and Apoptosis

2001 • 253 citations

Specific Cleavage of Mcl-1 by Caspase-3 in Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis in Jurkat Leukemia T Cells

2005 • 252 citations

Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis.

1993 • 237 citations

Targets and mechanisms for the regulation of translation in malignant transformation

2004 • 219 citations

Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

2000 • 188 citations

E2F1 and c-Myc in Cell Growth and Death

2003 • 169 citations

The identification of E2F1-specific target genes

2002 • 148 citations

Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis

2000 • 148 citations

SINK Is a p65-interacting Negative Regulator of NF-κB-dependent Transcription

2003 • 107 citations

Transcriptional Regulation of AKT Activation by E2F

2004 • 106 citations

Disruption of β-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice

2004 • 99 citations

The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP

2002 • 75 citations

Secreted Site-1 Protease Cleaves Peptides Corresponding to Luminal Loop of Sterol Regulatory Element-binding Proteins

1999 • 74 citations

Bcr-Abl-Mediated Protection from Apoptosis Downstream of Mitochondrial Cytochrome c Release

2004 • 58 citations

Antisense Depletion of Death-associated Protein Kinase Promotes Apoptosis

2003 • 47 citations

Regulation of the cell cycle in response to inhibition of mitochondrial generated energy

2005 • 44 citations

MAT1-Modulated CAK Activity Regulates Cell Cycle G₁ Exit

2001 • 32 citations

Altered gene expression in acute systemic inflammation detected by complete coverage of the human liver transcriptome

2004 • 31 citations

Diabetes and hepatocellular carcinoma: Associations, biologic plausibility, and clinical implications

2005 • 22 citations

Genome-wide response of the human Hep3B hepatoma cell to proinflammatory cytokines, from transcription to translation

2005 • 15 citations