Bcr-Abl-Mediated Protection from Apoptosis Downstream of Mitochondrial Cytochrome c Release

The Hallmarks of Cancer

2000 • 27,569 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

Caspases: Enemies Within

1998 • 6,923 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Cell Death

2004 • 4,599 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

The expanding role of mitochondria in apoptosis.

2001 • 2,377 citations

IAP proteins: blocking the road to death's door

2002 • 1,753 citations

The molecular biology of chronic myeloid leukemia

2000 • 1,596 citations

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

2000 • 1,484 citations

Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

1998 • 1,132 citations

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

2001 • 960 citations

Negative regulation of the Apaf-1 apoptosome by Hsp70

2000 • 819 citations

Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

1998 • 756 citations

Mechanism of XIAP-Mediated Inhibition of Caspase-9

2003 • 675 citations

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

1993 • 667 citations

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.

1988 • 602 citations

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway

1997 • 591 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia

1994 • 514 citations

Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification

2000 • 511 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 495 citations

Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK

2003 • 463 citations

Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia.

1996 • 452 citations

Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance

2002 • 437 citations

Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

1995 • 419 citations

Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system

1997 • 388 citations

Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes

2001 • 388 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 378 citations

BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: a mechanism of resistance to multiple anticancer agents

1995 • 363 citations

Blockade of the Bcr-Abl Kinase Activity Induces Apoptosis of Chronic Myelogenous Leukemia Cells by Suppressing Signal Transducer and Activator of Transcription 5–Dependent Expression of Bcl-XL

2000 • 362 citations

Cell-specific Induction of Apoptosis by Microinjection of Cytochrome c

1997 • 348 citations

Caspase Activation Involves the Formation of the Aposome, a Large (∼700 kDa) Caspase-activating Complex

1999 • 298 citations

Roots of Clinical Resistance to STI-571 Cancer Therapy

2001 • 291 citations

Evidence of a Novel Event during Neuronal Death

1998 • 276 citations

Bcl-2-independent Bcr–Abl-mediated resistance to apoptosis: protection is correlated with up regulation of Bcl-xL

1998 • 238 citations

The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells

1997 • 228 citations

Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2.

1995 • 207 citations

Aven, a Novel Inhibitor of Caspase Activation, Binds Bcl-xL and Apaf-1

2000 • 205 citations

The Survival Function of the Bcr-Abl Oncogene Is Mediated by Bad-Dependent and -Independent Pathways: Roles for Phosphatidylinositol 3-Kinase and Raf

2000 • 188 citations

Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis

2003 • 151 citations

Dysfunctional apoptosome activation in ovarian cancer: implications for chemoresistance.

2002 • 145 citations

Apaf-1 protein deficiency confers resistance to cytochromec–dependent apoptosis in human leukemic cells

2001 • 143 citations

BCR/ABL regulates response to DNA damage: the role in resistance to genotoxic treatment and in genomic instability

2002 • 136 citations

XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis

2002 • 124 citations

Pro-apoptotic Proteins Released from the Mitochondria Regulate the Protein Composition and Caspase-processing Activity of the Native Apaf-1/Caspase-9 Apoptosome Complex

2004 • 120 citations

STI-571: an anticancer protein-tyrosine kinase inhibitor

2003 • 112 citations

Mitochondria in Apoptosis and Human Disease

2001 • 106 citations

Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inhibited by Bcl-2

1998 • 95 citations

Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells

2001 • 92 citations

Role of Smac in human leukaemic cell apoptosis and proliferation

2003 • 63 citations

Post–Cytochrome c Protection from Apoptosis Conferred by a MAPK Pathway inXenopusEgg Extracts

2002 • 56 citations

Genomic Mechanisms of p210BCR-ABL Signaling

2004 • 53 citations

Crk is required for apoptosis in Xenopus egg extracts

1997 • 48 citations

Differentiation-dependent Sensitivity to Apoptogenic Factors in PC12 Cells

2004 • 43 citations

Comparison of the anti‐apoptotic effects of Bcr‐Abl, Bcl‐2 and Bcl‐x_L following diverse apoptogenic stimuli

2003 • 41 citations

Baculovirus expression of functional P210 BCR-ABL oncogene product.

1989 • 39 citations

Bcr – Abl-mediated resistance to apoptosis is independent of PI 3-kinase activity

1997 • 31 citations

Caspase Phosphorylation, Cell Death, and Species Variability

2000 • 27 citations