Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study

Anti-CD3 Monoclonal Antibody in New-Onset Type 1 Diabetes Mellitus

2002 • 1,189 citations

Insulin Needs after CD3-Antibody Therapy in New-Onset Type 1 Diabetes

2005 • 1,080 citations

Effects of Insulin in Relatives of Patients with Type 1 Diabetes Mellitus

2002 • 803 citations

Effects of Oral Insulin in Relatives of Patients With Type 1 Diabetes

2005 • 630 citations

β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial

2001 • 513 citations

Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?

2005 • 485 citations

Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

2004 • 482 citations

Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial

2002 • 354 citations

Peptide-based therapeutic vaccines for allergic and autoimmune diseases

2005 • 318 citations

A Comprehensive Review of Interventions in the NOD Mouse and Implications for Translation

2005 • 316 citations

Use of Inhaled Insulin in a Basal/Bolus Insulin Regimen in Type 1 Diabetic Subjects

2005 • 274 citations

Stratification of Type 1 Diabetes Risk on the Basis of Islet Autoantibody Characteristics

2004 • 271 citations

Translational Mini-Review Series on Type 1 Diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes

2007 • 264 citations

Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes

2005 • 220 citations

Limited Duration of Remission of Insulin Dependency in Children With Recent Overt Type I Diabetes Treated With Low-Dose Cyclosporin

1990 • 168 citations

Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4

1999 • 159 citations

T Cell Epitope Immunotherapy Induces a CD4+ T Cell Population with Regulatory Activity

2005 • 159 citations

Induction of interleukin‐10 and suppressor of cytokine signalling‐3 gene expression following peptide immunotherapy

2006 • 142 citations

Translational Mini-Review Series on Type 1 Diabetes: Immune-based therapeutic approaches for type 1 diabetes

2007 • 140 citations

Update on the current status of peptide immunotherapy

2007 • 97 citations

Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23

2002 • 96 citations

Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23

2002 • 76 citations

Antibodies against homologous microbial caseinolytic proteases P characterise primary biliary cirrhosis

2002 • 71 citations

Immunomodulation in Type 1 Diabetes by NBI‐6024, an Altered Peptide Ligand of the Insulin B₍₉₋₂₃₎ Epitope

2005 • 71 citations

Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes

2008 • 62 citations

Antigen‐specific immunotherapy for autoimmune disease: fighting fire with fire?

2001 • 59 citations

Specific antigen vaccination to treat autoimmune disease

2004 • 50 citations

Predominantly Recognized ProInsulin T Helper Cell Epitopes in Individuals With and Without Islet Cell Autoimmunity

2002 • 48 citations

Humoral and cellular immune responses to proinsulin in adults with newly diagnosed type 1 diabetes

2002 • 33 citations

Association of interferon-γ and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes

2006 • 31 citations

Role of interleukin-10 in the induction and function of natural and antigen-induced regulatory T cells

2003 • 26 citations

Preventing peptide-induced anaphylaxis: Addition of C-terminal amino acids to produce a neutral isoelectric point☆

2004 • 15 citations

The ‘dead in bed syndrome’– a cause of sudden death in Type 1 diabetes mellitus

2007 • 13 citations