An absolute requirement for Fyn in T cell receptor‐induced caspase activation and apoptosis

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1998 • 1,651 citations

Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1

2000 • 992 citations

Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α

1996 • 665 citations

Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice

1999 • 641 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

1995 • 486 citations

Caspase Activation Is Required for T Cell Proliferation

1999 • 462 citations

THE DYNAMICS OF T CELL RECEPTOR SIGNALING: Complex Orchestration and the Key Roles of Tempo and Cooperation

1999 • 439 citations

Early Activation of Caspases during T Lymphocyte Stimulation Results in Selective Substrate Cleavage in Nonapoptotic Cells

1999 • 387 citations

Caspase-3-mediated Cleavage of Protein Kinase C θ in Induction of Apoptosis

1997 • 308 citations

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

1997 • 265 citations

A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis

1999 • 224 citations

BTK as a Mediator of Radiation-Induced Apoptosis in DT-40 Lymphoma B Cells

1996 • 166 citations

Evidence for CPP32 Activation in the Absence of Apoptosis during T Lymphocyte Stimulation

1997 • 155 citations

Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases.

1987 • 139 citations

The Cbl Proto-Oncogene Product Negatively Regulates the Src-Family Tyrosine Kinase Fyn by Enhancing Its Degradation

2000 • 122 citations

Differential T-Cell Antigen Receptor Signaling Mediated by the Src Family Kinases Lck and Fyn

2000 • 110 citations

Fyn and ZAP-70 Are Required for Vav Phosphorylation in T Cells Stimulated by Antigen-presenting Cells

1998 • 101 citations

Anergic Th1 cells express altered levels of the protein tyrosine kinases p56lck and p59fyn.

1992 • 89 citations

Specific Association of Tyrosine-phosphorylated c-Cbl with Fyn Tyrosine Kinase in T Cells

1996 • 75 citations

A Physical Interaction between the Cell Death Protein Fas and the Tyrosine Kinase p59

1996 • 73 citations

Analysis of tetanus toxin peptide/DR recognition by human T cell receptors reconstituted into a murine T cell hybridoma

1993 • 70 citations

Overexpression of src family gene for tyrosine-kinase p59fyn in CD4-CD8- T cells of mice with a lymphoproliferative disorder.

1989 • 68 citations

Distinctive Functions of Syk and Lyn in Mediating Osmotic Stress- and Ultraviolet C Irradiation-induced Apoptosis in Chicken B Cells

1997 • 65 citations

Cleavage of the Serum Response Factor during Death Receptor-induced Apoptosis Results in an Inhibition of the c-FOS Promoter Transcriptional Activity

2000 • 53 citations

Physical and functional interactions of protein tyrosine kinases, p59fyn and ZAP-70, in T cell signaling.

1996 • 46 citations

Catalytic activity of the mouse guanine nucleotide exchanger mSOS is activated by Fyn tyrosine protein kinase and the T-cell antigen receptor in T cells.

1996 • 45 citations

Direct Interaction in T-cells between θPKC and the Tyrosine Kinase p59fyn

1999 • 37 citations

Caspases in T-cell receptor-induced thymocyte apoptosis

1999 • 36 citations

Cleavage and relocation of the tyrosine kinase P59FYN during Fas-mediated apoptosis in T lymphocytes

1999 • 30 citations

Protein tyrosine kinase Lyn mediates apoptosis induced by topoisomerase II inhibitors in DT40 cells

1999 • 18 citations

Fyn Membrane Localization Is Necessary to Induce the Constitutive Tyrosine Phosphorylation of Sam68 in the Nucleus of T Lymphocytes

1999 • 18 citations

Tyrosine phosphorylation participates in peripheral T-cell activation and programmed cell death in vivo.

1995 • 15 citations

CD10 is expressed on human thymic epithelial cell lines and modulates thymopentin‐induced cell proliferation

1997 • 13 citations