Thromboxane synthetase inhibitors reduce infarct size by a platelet-dependent, aspirin-sensitive mechanism.

Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker

1982 • 3,566 citations

Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina

1983 • 1,740 citations

Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

1982 • 1,241 citations

Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog.

1983 • 1,168 citations

Aspirin, Sulfinpyrazone, or Both in Unstable Angina

1985 • 1,146 citations

Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemie myocardium

1985 • 994 citations

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

1976 • 956 citations

Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

1984 • 915 citations

The rate-pressure product as an index of myocardial oxygen consumption during exercise in patients with angina pectoris.

1978 • 835 citations

Coronary Arterial Smooth Muscle Contraction by a Substance Released from Platelets: Evidence That It Is Thromboxane A ₂

1976 • 504 citations

Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs.

1984 • 468 citations

Persantine and aspirin in coronary heart disease. The Persantine-Aspirin Reinfarction Study Research Group.

1980 • 464 citations

UNSTABLE METABOLITES OF ARACHIDONIC ACID AND THEIR ROLE IN HAEMOSTASIS AND THROMBOSIS

1978 • 447 citations

Synthesis of Prostacyclin from Platelet-derived Endoperoxides by Cultured Human Endothelial Cells

1980 • 385 citations

ASPIRIN AND SECONDARY MORTALITY AFTER MYOCARDIAL INFARCTION

1979 • 361 citations

Leukocytes and Ischemia-Induced Myocardial Injury

1986 • 321 citations

: A selective inhibitor of thromboxane synthetase

1977 • 303 citations

Thromboxane generation by human peripheral blood polymorphonuclear leukocytes.

1978 • 229 citations

Thromboxane and prostacyclin release from ischaemic myocardium in relation to arrhythmias

1981 • 220 citations

Application of imidazole as a selective inhibitor thromboxane synthetase in human platelets.

1977 • 215 citations

Thromboxane A2 Mediates Augmented Polymorphonuclear Leukocyte Adhesiveness

1980 • 205 citations

Nafazatrom-induced salvage of ischemic myocardium in anesthetized dogs is mediated through inhibition of neutrophil function.

1985 • 137 citations

ISomerization of prostaglandin H2 into prostaglandin D2 in the presence of serum albumin

1976 • 137 citations

Endogenous prostacyclin contributes to the efficacy of a thromboxane synthetase inhibitor for preventing coronary artery thrombosis.

1981 • 120 citations

Interactions between prostaglandins and leukotrienes

1984 • 119 citations

Polymorphonuclear leukocytes produce thromboxane A2-like activity during phagocytosis

1976 • 114 citations

13-Azaprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptor.

1979 • 113 citations

Dissimilar effects of prostacyclin, prostaglandin E1, and prostaglandin E2 on myocardial infarct size after coronary occlusion in conscious dogs.

1981 • 106 citations

Prostacyclin in experimental myocardial ischemia: Effects on hemodynamics, regional myocardial blood flow, infarct size and mortality

1981 • 103 citations

The salvage of ischaemic myocardium by BW755C in anaesthetised dogs

1982 • 102 citations

Canine myocardial reperfusion injury: protection by a free radical scavenger, N-2-mercaptopropionyl glycine.

1986 • 95 citations

Neutrophil Depletion Suppresses 111In-Labeled Platelet Accumulation in Infarcted Myocardium

1985 • 95 citations

Thromboxane A2, prostacyclin and aspirin: effects on vascular tone and platelet aggregation.

1980 • 78 citations

Characterization of the biosynthetic pathway of prostaglandin D2 in human platelet-rich plasma.

1982 • 77 citations

Lack of effect of aspirin on myocardial infarct size in the dog

1981 • 74 citations

Influence of thromboxane inhibition on the severity of myocardial ischemia in cats

1980 • 73 citations

Myeloperoxidase Activity as a Quantitative Marker of Polymorphonuclear Leukocyte Accumulation into an Experimental Myocardial Infarct—The Effect of Ibuprofen on Infarct Size and Polymorphonuclear Leukocyte Accumulation

1985 • 72 citations

EFFECTS OF MODULATORS OF ARACHIDONIC ACID METABOLISM ON THE SYNTHESIS AND RELEASE OF SLOW‐REACTING SUBSTANCE OF ANAPHYLAXIS

1979 • 64 citations

Biotransformation and cardiovascular effects of arachidonic acid in the dog

1979 • 59 citations

Myocardial Salvage Induced by REV-5901

1987 • 57 citations

Selective and nonselective inhibition of thromboxane formation

1984 • 56 citations

Further evidence that thromboxane exacerbates arrhythmias: Effects of UK38485 during coronary artery occlusion and reperfusion in anaesthetized greyhounds

1984 • 54 citations

Platelet trapping in myocardial infarct in baboons: Therapeutic effect of aspirin

1980 • 51 citations

Preservation of ischemic myocardium by pinane thromboxane A2

1980 • 48 citations

Effects of dazoxiben on arrhythmias and ventricular fibrillation induced by coronary artery occlusion and reperfusion in anaesthetised greyhounds.

1983 • 46 citations

Roles of Endogenous Prostacyclin and Thromboxane A2 in the Ischemic Canine Heart

1982 • 46 citations

Platelet Depletion and Infarct Size in an Occlusion Reperfusion Model of Myocardial Ischemia in Anesthetized Dogs

1985 • 45 citations

Kinetics and imaging of indium-11-labeled autologous platelets in experimental myocardial infarction.

1983 • 45 citations

Prevention of extension of ischaemic damage following acute myocardial ischaemia by dazoxiben, a new thromboxane synthetase inhibitor.

1983 • 37 citations

The interactions of platelet-derived mediators on isolated canine coronary arteries

1982 • 36 citations

Platelet depletion in experimental myocardial infarction

1985 • 35 citations

Protection of Ischemic Cat Myocardium By CGS-13080, a Selective Potent Thromboxane A2 Synthesis Inhibitor

1983 • 35 citations

Myocardial platelet trapping after coronary ligation in primates (Papio anubis) Platelet trapping in infarct marginal zone

1979 • 32 citations

Imaging of the inflammatory response in ischemic canine myocardium with 111indium-labeled leukocytes

1977 • 30 citations

The effects of RO-22-4679, a thromboxane synthetase inhibitor, on ventricular fibrillation induced by coronary artery occlusion in conscious dogs.

1983 • 27 citations

Sudden, unexpected coronary death. The occurrence of platelet aggregates in the epicardial and myocardial vessels of man.

1978 • 17 citations

Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with dazoxiben hydrochloride (UK 37,248‐01).

1983 • 17 citations

Effect of OKY-1581, a thromboxane synthetase inhibitor, on coronary thrombosis in the conscious dog

1984 • 14 citations

Thrombosis in the pathogenesis of sudden cardiac death and myocardial infarction.

1982 • 7 citations