Modeling human colon cancer in rodents using a food‐borne carcinogen, PhIP

Inflammation and cancer

2002 • 14,174 citations

Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland

2000 • 4,020 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1981 • 3,794 citations

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1983 • 3,602 citations

Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: Preliminary findings

1987 • 1,036 citations

Wnt signalling induces maturation of Paneth cells in intestinal crypts

2005 • 625 citations

Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish

2004 • 625 citations

Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays.

2001 • 607 citations

Meat Consumption and Risk of Colorectal Cancer

2005 • 583 citations

A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

1991 • 538 citations

Nutrition and dietary carcinogens

2000 • 370 citations

Mutagenicities of smoke condensates and the charred surface of fish and meat

1977 • 354 citations

DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis

1999 • 350 citations

The isolation and identification of a new mutagen from fried ground beef: 2-amino-l-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP)

1986 • 283 citations

Well-done, grilled red meat increases the risk of colorectal adenomas.

1999 • 226 citations

Identification of mucin-depleted foci in the unsectioned colon of azoxymethane-treated rats: correlation with carcinogenesis.

2003 • 177 citations

Heterocyclic Amine Content of Cooked Meat and Risk of Prostate Cancer

1999 • 177 citations

Carcinogen-specific induction of genetic instability

2001 • 174 citations

DNA and protein adduct formation in the colon and blood of humans after exposure to a dietary-relevant dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

1999 • 167 citations

Identification of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine as the major adduct formed by the food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, with DNA

1992 • 161 citations

Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

1995 • 148 citations

Assessment of the human exposure to heterocyclic amines

1997 • 146 citations

Mutagenicities of protein pyrolysates

1977 • 142 citations

Analysis of DNA Adducts of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Rat and Human Tissues by Alkaline Hydrolysis and Gas Chromatography/Electron Capture Mass Spectrometry: Validation by Comparison with 32P-Postlabeling

1994 • 139 citations

High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat.

1998 • 129 citations

Dose-dependence of 2-amino-1-methy1–6-phenylimidazo[4, 5-b]-pyridine (PhIP) carcinogenicity in rats

1993 • 128 citations

Induction of mammary tumors in female Sprague—Dawley rats by the food-derived carcinogen 2-amino-1-methyl-6-phenyliniidazo [4,5-b]pyridine and effect of dietary fat

1994 • 122 citations

Secreted and cell surface genes expressed in benign and malignant colorectal tumors.

2001 • 122 citations

Sequential analysis of morphological and biological properties of beta-catenin-accumulated crypts, provable premalignant lesions independent of aberrant crypt foci in rat colon carcinogenesis.

2001 • 104 citations

Role of well-done, grilled red meat, heterocyclic amines (HCAs) in the etiology of human cancer

1999 • 97 citations

Genetic changes induced by heterocyclic amines

1997 • 95 citations

A new approach to risk estimation of food-borne carcinogens — heterocyclic amines — based on molecular information

1999 • 91 citations

The cooked food derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine is a potent oestrogen: a mechanistic basis for its tissue-specific carcinogenicity

2004 • 91 citations

Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine and dextran sodium sulfate in male ICR mice possess β- catenin gene mutations and increases immunoreactivity for β-catenin, cyclooxygenase-2 and inducible nitric oxide synthase

2004 • 86 citations

Human exposure to heterocyclic amine food mutagens/carcinogens: Relevance to breast cancer

2002 • 84 citations

Flat Dysplastic Aberrant Crypt Foci Are Related to Tumorigenesis in the Colon of Azoxymethane-Treated Rat

2005 • 78 citations

DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis

1996 • 74 citations

ACCELERATED PAPER: Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) at the Chinese hamster hprt locus

1996 • 74 citations

DNA Modification by 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine in Rats

1989 • 71 citations

Determination of Polycyclic Aromatic Hydrocarbons in Coffee Brew Using Solid-Phase Extraction

2005 • 68 citations

Agreement of mutational characteristics of heterocyclic amines in lacI of the Big Blue mouse with those in tumor related genes in rodents

1997 • 65 citations

Characterization of Dysplastic Aberrant Crypt Foci in the Rat Colon Induced by 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine

2003 • 53 citations

Characterization of mutations induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the colon of gpt delta transgenic mouse: novel G:C deletions beside runs of identical bases

2000 • 50 citations

Existence of a Threshold for Induction of Aberrant Crypt Foci in the Rat Colon with Low Doses of 2-Amino-1-methyl-6-phenolimidazo[4,5-b]pyridine

2004 • 45 citations

A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, PhIP

2002 • 44 citations

Effects of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the lacI transgene

1997 • 43 citations

Genetic analysis of PHIP intestinal mutations in Muta^TMMouse

1998 • 41 citations

How we should deal with unavoidable exposure of man to environmental mutagens: cooked food mutagen discovery, facts and lessons for cancer prevention

2000 • 41 citations

Absence of p53 Mutations in Rat Colon Tumors Induced by 2‐Amino‐6‐methyldipyrido[1,2‐a:3′, 2′‐d]imidazole, 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline, or 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

1994 • 39 citations

Increased risk of mammary carcinoma development following transplacental and trans-breast milk exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), in Sprague-Dawley rats.

1995 • 38 citations

Efficient induction of rat large intestinal tumors with a new spectrum of mutations by intermittent administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in combination with a high fat diet

2002 • 37 citations

Interpretation of mutational spectra from different genes: analyses of PhIP-induced mutational specificity in the lacI and cII transgenes from colon of Big Blue® rats

2000 • 34 citations

Genetic alterations in rat colon tumors induced by heterocyclic amines

1996 • 32 citations

Differential staining of dysplastic aberrant crypt foci in the colon facilitates prediction of carcinogenic potentials of chemicals in rats

2004 • 32 citations

Reduction in formation of 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP)-induced aberrant crypt foci in the rat colon by docosahexaenoic acid (DHA)

1997 • 32 citations

Effect of dietary fat on codon 12 and 13 Ha-ras gene mutations in 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine–induced rat mammary gland tumors

1997 • 31 citations

Efficient Method for Rapid Induction of Aberrant Crypt Foci in Rats with 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

1996 • 31 citations

More Frequent β‐Catenin Gene Mutations in Adenomas than in Aberrant Crypt Foci or Adenocarcinomas in the Large Intestines of 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP)‐treated Rats

2000 • 27 citations

Analytical method of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in human hair by column-switching liquid chromatography–mass spectrometry

2004 • 25 citations

2‐hydroxyamino‐1‐methyl‐6‐phenylimidazo [4,5‐b] pyridine induction of recombinational mutations in mammalian cell lines as detected by dna fingerprinting

1994 • 24 citations

Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine

2004 • 23 citations

Strain differences of rats in the susceptibility to aberrant crypt foci formation by 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine: no implication of Apc and Pla2g2a genetic polymorphisms in differential susceptibility

1999 • 21 citations

Comparative genomic hybridization analysis of PhIP-induced mammary carcinomas in rats reveals a cytogenetic signature

2002 • 18 citations

Use of polyclonal antibodies against carcinogen–DNA adducts in analysis of carcinogenesis

1998 • 18 citations

Regional mutagenicity of heterocyclic amines in the intestine: mutation analysis of the cII gene in lambda/lacZ transgenic mice

2003 • 17 citations

Genetic alterations in rat colon tumors induced by heterocyclic amines

1996 • 13 citations

The role of fat and calcium in the production of foci of aberrant crypts in the colon of rats fed 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine.

1994 • 9 citations

Carcinogenic risk assessment of MeIQx and PhIP in a newborn mouse two-stage tumorigenesis assay

1999 • 7 citations

The Role of Fat and Calcium in the Production of Foci of Aberrant Crypts in the Colon of Rats Fed 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]-Pyridine

1994 • 2 citations

Deleted Work

1955 • 0 citations