Effects of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the lacI transgene

A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

1991 • 538 citations

Sequence of the lacI gene

1978 • 463 citations

The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods.

1997 • 392 citations

DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis.

1993 • 334 citations

Carcinogens leave fingerprints

1992 • 169 citations

Identification of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine as the major adduct formed by the food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, with DNA

1992 • 161 citations

Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

1995 • 148 citations

Intestinal mutagenicity of two carcinogenic food mutagens in transgenic mice: 2-amino-l-methyl-6-phenylimidazo[4, 5-b]pyridine and amino(α)carboline

1996 • 75 citations

DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis

1996 • 74 citations

ACCELERATED PAPER: Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) at the Chinese hamster hprt locus

1996 • 74 citations

Agreement of mutational characteristics of heterocyclic amines in lacI of the Big Blue mouse with those in tumor related genes in rodents

1997 • 65 citations

Adduct Formation at C‐8 of Guanine on in vitro Reaction f the Ultimate Form of 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine with 2′‐Deoxyguanosine and Its Phosphate Esters

1992 • 58 citations

Organ variation in the mutagenicity of MeIQ in Big Blue® lacI transgenic mice

1996 • 55 citations

Detection of Guanine‐C8‐2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine Adduct as a Single Spot on Thin‐layer Chromatography by Modification of the ³²P‐Postlabeling Method

1994 • 47 citations

Mutational specificity: An efficient laboratory protocol for the sequencing of large numbers oflacl mutants recovered from Big Blue® transgenic animals

1996 • 45 citations

Mutagenic specificity of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the supF shuttle vector system.

1994 • 41 citations

Identification of N-(deoxyguanosin-8-yl)–2-amino-3,4-dimethylimidazo[4,5-f]quinoline (dG-C8–MeIQ) as a major adduct formed by MeIQ with nucleotides in vitro and with DNA in vivo

1994 • 34 citations

A rapid method for detection of mutations in the lacI gene using PCR-single strand conformation polymorphism analysis: demonstration of its high sensitivity

1995 • 33 citations