Absence of p53 Mutations in Rat Colon Tumors Induced by 2‐Amino‐6‐methyldipyrido[1,2‐a:3′, 2′‐d]imidazole, 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline, or 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

1989 • 3,707 citations

The evolution of cancer of the colon and rectum

1975 • 2,120 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

1990 • 1,080 citations

PCR-SSCP: a simple and sensitive method for detection of mutations in the genomic DNA.

1991 • 780 citations

TP53 tumor suppressor gene: A model for investigating human mutagenesis

1992 • 584 citations

A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

1991 • 538 citations

How sensitive is PCR-SSCP?

1993 • 468 citations

Food-derived mutagens and carcinogens.

1992 • 450 citations

The isolation and identification of a new mutagen from fried ground beef: 2-amino-l-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP)

1986 • 283 citations

Analysis of DNA extracted from formalin-fixed, paraffin-embedded tissues by enzymatic amplification and hybridization with sequence-specific oligonucleotides

1987 • 260 citations

The evolution of cancer of the colon and rectum

2010 • 234 citations

Carcinogens leave fingerprints

1992 • 169 citations

Potent novel mutagens produced by broiling fish under normal conditions.

1980 • 154 citations

Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP).

1993 • 149 citations

Demonstration of carcinogenicity in F344 rats of 2-amino-3-methyl-imidazo[4,5-f]quinoline from broiled sardine, fried beef and beef extract.

1984 • 146 citations

Isolation and structure determination of mutagenic substances in L-glutamic acid pyrolysate.

1978 • 139 citations

Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa.

1991 • 117 citations

Evidence for a ras gene mutation in azoxymethane-induced colonic aberrant crypts in Sprague—Dawley rats: earliest recognizable precursor lesions of experimental colon cancer

1992 • 94 citations

K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency.

1991 • 90 citations

p53 mutations in formaldehyde-induced nasal squamous cell carcinomas in rats.

1992 • 88 citations

Structure of the rat p53 tumor suppressor gene

1993 • 86 citations

Rat p53 gene mutations in primary Zymbal gland tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline, a food mutagen.

1992 • 78 citations

Detection of 2-amino-3-methylimidazo[4,5-f]quinoline in cigarette smoke condensate.

1986 • 70 citations

Induction of cancers in the intestine, liver and various other organs of rats by feeding mutagens from glutamic acid pyrolysate.

1984 • 63 citations

K-ras oncogene mutations in rat colon tumors induced by N-methyl-N-nitrosourea

1992 • 59 citations

p53 mutations in hepatocellular carcinomas induced by a choline-devoid diet in male Fischer 344 rats

1993 • 48 citations

Rare frequency of activation of the ki‐ras gene in rat colon tumors induced by heterocyclic amines: Possible alternative mechanisms of human colon carcinogenesis

1993 • 40 citations

Genetic alterations in HCA-induced tumors.

1995 • 18 citations