Childhood obesity: behavioral aberration or biochemical drive? Reinterpreting the First Law of Thermodynamics

Prevalence and Trends in Overweight Among US Children and Adolescents, 1999-2000

2002 • 4,212 citations

Childhood obesity: public-health crisis, common sense cure

2002 • 3,046 citations

Obesity and the Environment: Where Do We Go from Here?

2003 • 2,205 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

Changes in Energy Expenditure Resulting from Altered Body Weight

1995 • 1,926 citations

Brain dopamine and obesity

2001 • 1,817 citations

Health-Related Quality of Life of Severely Obese Children and Adolescents

2003 • 1,794 citations

Towards a molecular understanding of adaptive thermogenesis

2000 • 1,560 citations

Recombinant Leptin for Weight Loss in Obese and Lean Adults

1999 • 1,408 citations

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

2002 • 1,312 citations

Obesity Wars

2004 • 1,119 citations

Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure

2005 • 1,053 citations

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

2002 • 1,051 citations

Receptor-mediated regional sympathetic nerve activation by leptin.

1997 • 980 citations

Decline in Physical Activity in Black Girls and White Girls during Adolescence

2002 • 959 citations

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

2000 • 873 citations

PTP1B Regulates Leptin Signal Transduction In Vivo

2002 • 785 citations

Effect of fasting on serum leptin in normal human subjects.

1996 • 744 citations

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

2004 • 632 citations

Premature Birth and Later Insulin Resistance

2004 • 604 citations

Key enzyme in leptin-induced anorexia

2001 • 574 citations

Energy and fat intakes of children and adolescents in the United States: data from the National Health and Nutrition Examination Surveys

2000 • 563 citations

Molecular and anatomical determinants of central leptin resistance

2005 • 543 citations

What’s in a Name? In Search of Leptin’s Physiologic Role¹

1998 • 527 citations

Opioid modulation of taste hedonics within the ventral striatum

2002 • 514 citations

SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling

2000 • 454 citations

Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities

2003 • 427 citations

Adiposity and Hyperinsulinemia in Indians Are Present at Birth

2002 • 417 citations

Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean

2001 • 373 citations

Low Dose Leptin Administration Reverses Effects of Sustained Weight-Reduction on Energy Expenditure and Circulating Concentrations of Thyroid Hormones

2002 • 369 citations

Selective parasympathetic innervation of subcutaneous and intra-abdominal fat — functional implications

2002 • 368 citations

Insulin and insulin-like growth factors in the CNS

1988 • 334 citations

Insulin Signaling in the Central Nervous System

2005 • 330 citations

Impaired transport of leptin across the blood-brain barrier in obesity☆

1999 • 328 citations

Selective parasympathetic innervation of subcutaneous and intra-abdominal fat — functional implications

2002 • 317 citations

Current and Potential Drugs for Treatment of Obesity

1999 • 302 citations

Risk Factors for the Development of Obesity in Children Surviving Brain Tumors

2003 • 298 citations

Octreotide Therapy of Pediatric Hypothalamic Obesity: A Double-Blind, Placebo-Controlled Trial

2003 • 284 citations

Effects of Weight Change on Plasma Leptin Concentrations and Energy Expenditure¹

1997 • 267 citations

Outcome of craniopharyngioma in children: long-term complications and quality of life

2004 • 252 citations

Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects

2003 • 247 citations

Outcome of craniopharyngioma in children: long‐term complications and quality of life

2004 • 244 citations

Fast Food, Central Nervous System Insulin Resistance, and Obesity

2005 • 242 citations

Hyperinsulinemia in African-American Children

2002 • 237 citations

The role of insulin receptor substrate 2 in hypothalamic and β cell function

2005 • 231 citations

Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus

2004 • 230 citations

MANIFESTATIONS OF HYPOTHALAMIC OBESITY IN MAN: A COMPREHENSIVE INVESTIGATION OF EIGHT PATIENTS AND A EEVIEW OF THE LITERATURE

1975 • 229 citations

Autonomic nervous system activity in weight gain and weight loss

1995 • 223 citations

Adiposity signals and food reward: expanding the CNS roles of insulin and leptin

2003 • 218 citations

Fetal origins of insulin resistance and obesity

2005 • 203 citations

Obesity in Patients with Craniopharyngioma: Assessment of Food Intake and Movement Counts Indicating Physical Activity

2003 • 193 citations

Leptin Attenuates Acute Food Deprivation-Induced Relapse to Heroin Seeking

2001 • 184 citations

Intraventricular insulin increases dopamine transporter mRNA in rat VTA/substantia nigra

1994 • 171 citations

Do adiponectin, TNFα, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy

2005 • 170 citations

Evidence of increased dopamine receptor signaling in food-restricted rats

2003 • 157 citations

BEHAVIORAL THERAPY IN THE TREATMENT OF PEDIATRIC OBESITY

2001 • 157 citations

Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet

2004 • 157 citations

Hypothalamic obesity caused by cranial insult in children: Altered glucose and insulin dynamics and reversal by a somatostatin agonist

1999 • 156 citations

Redistribution of Glucose From Skeletal Muscle to Adipose Tissue During Catch-Up Fat

2005 • 154 citations

Intracerebroventricular insulin produces nonuniform regional increases in sympathetic nerve activity

1994 • 132 citations

Mood and Cognitive Performance Effects of "Energy" Drink Constituents: Caffeine, Glucose and Carbonation

2004 • 121 citations

Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats

1990 • 113 citations

Obesity, leptin resistance, and the effects of insulin reduction

2004 • 100 citations

A multicenter, randomized, double-blind, placebo-controlled, dose-finding trial of a long-acting formulation of octreotide in promoting weight loss in obese adults with insulin hypersecretion

2005 • 100 citations

Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults

2003 • 93 citations

THE NEUROENDOCRINOLOGY OF CHILDHOOD OBESITY

2001 • 81 citations

Cerebrospinal Fluid and Plasma Concentrations of Leptin, NPY, andα -MSH in Obese Women and Their Relationship to Negative Energy Balance

2001 • 72 citations

A leptin‐sympathetic‐leptin feedback loop: potential implications for regulation of arterial pressure and body fat

2003 • 63 citations

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

2006 • 61 citations

Autonomic dysfunction of the beta-cell and the pathogenesis of obesity.

2003 • 60 citations

Bioactive food stimulants of sympathetic activity: effect on 24-h energy expenditure and fat oxidation

2005 • 52 citations

A Twin Study for Serum Leptin, Soluble Leptin Receptor, and Free Insulin-Like Growth Factor-I in Pubertal Females

2005 • 50 citations

Intraventricular insulin decreases kappa opioid-mediated sucrose intake in rats

2002 • 49 citations

Sympathoadrenal Counterregulation in Patients with Hypothalamic Craniopharyngioma

2002 • 43 citations

Direct effect of CNS on insulin hypersecretion in obese Zucker rats: involvement of vagus nerve

1989 • 38 citations

Racial and etiopathologic dichotomies in insulin hypersecretion and resistance in obese children

2005 • 32 citations

Adrenoceptor subtypes mediating catecholamine-induced thermogenesis in man.

1993 • 31 citations

Endocrine regulation of food intake and body weight

1996 • 31 citations

Effects of Diet and Time of the Day on Serum and CSF Leptin Levels in Osborne‐Mendel and S5B/Pl Rats

2004 • 22 citations

Serum Leptin in Nonpregnant and Pregnant Women and in Old and New World Nonhuman Primates

2005 • 19 citations

Reduced Anorexigenic Efficacy of Leptin, But Not of the Melanocortin Receptor Agonist Melanotan-II, Predicts Diet-Induced Obesity in Rats

2005 • 17 citations

The Efferent Arm of the Energy Balance Regulatory Pathway: Neuroendocrinology and Pathology

2007 • 11 citations