Building a Better Antipsychotic: Receptor Targets for the Treatment of Multiple Symptom Dimensions of Schizophrenia

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

The NIMH-MATRICS Consensus Statement on Negative Symptoms

2006 • 1,180 citations

Does Fast Dissociation From the Dopamine D₂ Receptor Explain the Action of Atypical Antipsychotics?: A New Hypothesis

2001 • 1,113 citations

<scp>d</scp> -Serine is an endogenous ligand for the glycine site of the N -methyl- <scp>d</scp> -aspartate receptor

2000 • 1,075 citations

NMDA receptor hypofunction model of schizophrenia

1999 • 1,007 citations

Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

1998 • 1,002 citations

Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs

2004 • 948 citations

Aripiprazole, a Novel Antipsychotic, Is a High-Affinity Partial Agonist at Human Dopamine D2 Receptors

2002 • 896 citations

Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications

2008 • 888 citations

A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms

1993 • 682 citations

D-Alanine Added to Antipsychotics for the Treatment of Schizophrenia

2005 • 670 citations

Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.

1993 • 607 citations

Ketamine-Induced NMDA Receptor Hypofunction as a Model of Memory Impairment and Psychosis

1999 • 593 citations

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors

1994 • 592 citations

Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission

2006 • 586 citations

Glutamate as a therapeutic target in psychiatric disorders

2004 • 525 citations

Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase.

1993 • 512 citations

5‐HT_2A and D₂ receptor blockade increases cortical DA release via 5‐HT_1A receptor activation: a possible mechanism of atypical antipsychotic‐induced cortical dopamine release

2001 • 491 citations

Modulation of N -methyl- <scp>d</scp> -aspartate receptor function by glycine transport

1998 • 410 citations

Interactions of the Novel Antipsychotic Aripiprazole (OPC-14597) with Dopamine and Serotonin Receptor Subtypes

1999 • 407 citations

The Efficacy and Safety of Aripiprazole as Adjunctive Therapy in Major Depressive Disorder

2007 • 399 citations

Neurotransmitter interactions in schizophrenia—therapeutic implications

1999 • 305 citations

Cellular localization of the 5-HT receptor in primate brain neurons and glial cells

1996 • 304 citations

Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile

2001 • 287 citations

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- <scp>d</scp> -aspartate receptor activity

2003 • 282 citations

Serotonin (5-HT)2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo

1998 • 278 citations

Characterization of SB‐269970‐A, a selective 5‐HT₇ receptor antagonist

2000 • 275 citations

Aripiprazole Monotherapy in Nonpsychotic Bipolar I Depression

2008 • 243 citations

Differential Effects of Aripiprazole on D₂, 5-HT₂, and 5-HT_1AReceptor Occupancy in Patients With Schizophrenia: A Triple Tracer PET Study

2007 • 234 citations

Molecular Targets for Treating Cognitive Dysfunction in Schizophrenia

2007 • 220 citations

Enhancement of Cognitive Performance in Schizophrenia by Addition of Tandospirone to Neuroleptic Treatment

2001 • 200 citations

The pipeline and future of drug development in schizophrenia

2007 • 185 citations

Intrinsic Efficacy of Antipsychotics at Human D₂, D₃, and D₄Dopamine Receptors: Identification of the Clozapine MetaboliteN-Desmethylclozapine as a D₂/D₃Partial Agonist

2005 • 182 citations

No hypothermic response to serotonin in 5-HT ₇ receptor knockout mice

2003 • 172 citations

Serotonin Receptors Involved in Vasopressin and Oxytocin Secretion

2003 • 170 citations

What's atypical about atypical antipsychotic drugs?

2003 • 168 citations

Modulation of dopamine release by striatal 5‐HT2C receptors

2005 • 165 citations

Effects of Antidepressants on 5-HT7 Receptor Regulation in the Rat Hypothalamus

1999 • 162 citations

Mice lacking 5‐HT₇ receptors show specific impairments in contextual learning

2004 • 142 citations

Serotonin regulates hippocampal glucocorticoid receptor expression via a 5-HT7 receptor

2002 • 131 citations

Attenuation of haloperidol‐induced catalepsy by a 5‐HT_2C receptor antagonist

1999 • 129 citations

Inhibitory Effect of Hippocampal 5-HT_1AReceptors on Human Explicit Memory

2003 • 124 citations

Comparative effects of glycine and d-cycloserine on persistent negative symptoms in schizophrenia: a retrospective analysis

2003 • 121 citations

SB‐656104‐A, a novel selective 5‐HT₇ receptor antagonist, modulates REM sleep in rats

2003 • 120 citations

A six-month, placebo-controlled trial of d-cycloserine co-administered with conventional antipsychotics in schizophrenia patients

2004 • 109 citations

Antipsychotic drug action: antagonism, inverse agonism or partial agonism

2008 • 104 citations

The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor

2003 • 99 citations

Beyond the Dopamine Hypothesis to the NMDA Glutamate Receptor Hypofunction Hypothesis of Schizophrenia

2007 • 92 citations

Is the glycine site half saturated or half unsaturated? Effects of glutamatergic drugs in schizophrenia patients

2006 • 89 citations

D-Cycloserine Increases Positive Symptoms in Chronic Schizophrenic Patients When Administered in Addition to Antipsychotics A Double-Blind, Parallel, Placebo-Controlled Study

1999 • 84 citations

8-OH-DPAT facilitated memory consolidation and increased hippocampal and cortical cAMP production

2003 • 71 citations

Further evidence for the association between 5-HT2C receptor gene polymorphisms and extrapyramidal side effects in male schizophrenic patients

2008 • 61 citations

Novel mechanism of antidepressant action: norepinephrine and dopamine disinhibition (NDDI) plus melatonergic agonism

2007 • 31 citations

Novel Therapeutics for Schizophrenia: Targeting Glycine Modulation of NMDA Glutamate Receptors

2007 • 18 citations

Do Dopamine Partial Agonists Have Partial Efficacy as Antipsychotics?

2008 • 17 citations