Molecular Genetic Mechanisms of Life Span Manipulation in Caenorhabditis elegans

A C. elegans mutant that lives twice as long as wild type

1993 • 3,250 citations

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

1991 • 3,108 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

Gene Expression Profile of Aging and Its Retardation by Caloric Restriction

1999 • 1,483 citations

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.

1988 • 958 citations

Signals from the reproductive system regulate the lifespan of C. elegans

1999 • 956 citations

The genetics of caloric restriction in Caenorhabditis elegans

1998 • 918 citations

Molecular Biology of Aging

1999 • 877 citations

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1996 • 870 citations

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.

1995 • 847 citations

Thedaf‐2gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression inCaenorhabditis elegans

1999 • 721 citations

Aging and resistance to oxidative damage in Caenorhabditis elegans.

1993 • 720 citations

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1998 • 680 citations

Genetic analysis of ageing: role of oxidative damage and environmental stresses

1996 • 647 citations

Genes that regulate both development and longevity in Caenorhabditis elegans.

1995 • 579 citations

Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes

1996 • 529 citations

The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.

1995 • 442 citations

The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic Signaling Pathway

1998 • 440 citations

A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results

1983 • 427 citations

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

1999 • 421 citations

Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing.

1995 • 406 citations

Increased Life-Span of age -1 Mutants in Caenorhabditis elegans and Lower Gompertz Rate of Aging

1990 • 402 citations

A Genetic Pathway Conferring Life Extension and Resistance to UV Stress in Caenorhabditis elegans

1996 • 390 citations

Oxidative stress and ageing in Caenorhabditis elegans

1993 • 383 citations

Cell Nonautonomy of C. elegans daf-2 Function in the Regulation of Diapause and Life Span

1998 • 362 citations

Structural and Functional Conservation of the Caenorhabditis elegans Timing Gene clk-1

1997 • 309 citations

Genetic analysis of life-span in Caenorhabditis elegans.

1982 • 302 citations

Production of sperm reduces nematode lifespan

1992 • 301 citations

An Ancient Developmental Induction: Heat-Shock Proteins Induced in Sporulation and Oogenesis

1986 • 294 citations

Reverse genetics by chemical mutagenesis in Caenorhabditis elegans

1997 • 282 citations

Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate

1999 • 280 citations

CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans

1999 • 274 citations

A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants

1999 • 244 citations

Longevity in Caenorhabditis elegans reduced by mating but not gamete production

1996 • 221 citations

Thermotolerance of a Long-lived Mutant of Caenorhabditis elegans

1994 • 208 citations

Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans.

1987 • 171 citations

Chapter 2 Mutagenesis

1995 • 159 citations

Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN

1999 • 142 citations

Mechanisms and Evolution of Aging

1996 • 132 citations

Hypothesis: Interventions That Increase the Response to Stress Offer the Potential for Effective Life Prolongation and Increased Health

1996 • 132 citations

Yeast Clk-1 Homologue (Coq7/Cat5) Is a Mitochondrial Protein in Coenzyme Q Synthesis

1998 • 131 citations

Genetic Analysis of the Roles of daf28 and age-1 in Regulating Caenorhabditis elegans Dauer Formation

1996 • 129 citations

Apparent uncoupling of energy production and consumption in long-lived Clk mutants of Caenorhabditis elegans

1999 • 123 citations

Increased frequency of deletions in the mitochondrial genome with age ofCaenorhabditis elegans

1995 • 119 citations

Neurosecretory control of aging in Caenorhabditis elegans

1999 • 118 citations

Rate of aerobic metabolism and superoxide production rate potential in the nematodeCaenorhabditis elegans

1996 • 115 citations

Quantitative Trait Loci Affecting Survival and Fertility-Related Traits in Caenorhabditis elegans Show Genotype-Environment Interactions, Pleiotropy and Epistasis

1999 • 115 citations

Life extension and stress resistance in Caenorhabditis elegans. modulated by the tkr-1 gene

1998 • 88 citations

Mapping Quantitative Trait Loci Affecting Life History Traits in the Nematode Caenorhabditis elegans

1996 • 69 citations

The Nature of Gerontogenes and Vitagenes: Antiaging Effects of Repeated Heat Shock on Human Fibroblasts

1998 • 68 citations

The Search for the Genetic Basis of Aging: The Identification of Gerontogenes in the Nematode Caenorhabditis elegans

1992 • 67 citations

Ponce d'elegans: Genetic Quest for the Fountain of Youth

1996 • 59 citations

Direct isolation of longevity mutants in the nematodeCaenorhabditis elegans

1996 • 40 citations

Aging of C. elegans

1998 • 36 citations

The spe-10 mutant has longer life and increased stress resistance☆

1999 • 31 citations

Defining genes that govern longevity inCaenorhabditis elegans

1996 • 29 citations

Characterization of a Life-Extending Mutation in age-2, a New Aging Gene in Caenorhabditis elegans

1999 • 23 citations