Temperature dependence of cell-cell fusion induced by the envelope glycoprotein of human immunodeficiency virus type 1

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

Membrane Fusion

1990 • 2,458 citations

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

1984 • 2,441 citations

Complete nucleotide sequence of the AIDS virus, HTLV-III

1985 • 2,236 citations

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

Binding of HTLV-III/LAV to T4 ⁺ T Cells by a Complex of the 110K Viral Protein and the T4 Molecule

1986 • 988 citations

Functional Regions of the Envelope Glycoprotein of Human Immunodeficiency Virus Type 1

1987 • 883 citations

Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity

1986 • 804 citations

How Does HIV Cause AIDS?

1993 • 668 citations

Virus Entry into Animal Cells

1989 • 625 citations

Membrane Fusion

1992 • 613 citations

Dissociation of gp120 from HIV-1 Virions Induced by Soluble CD4

1990 • 598 citations

Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.

1991 • 598 citations

Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein

1986 • 593 citations

Cell fusion by Semliki Forest, influenza, and vesicular stomatitis viruses.

1981 • 569 citations

Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160.

1988 • 442 citations

Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response.

1989 • 416 citations

Soluble CD4 molecules neutralize human immunodeficiency virus type 1

1988 • 403 citations

Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41.

1990 • 348 citations

Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates

1992 • 287 citations

Virus receptors: binding, adhesion strengthening, and changes in viral structure

1994 • 273 citations

Compartmentalized structure of the plasma membrane for receptor movements as revealed by a nanometer-level motion analysis.

1994 • 268 citations

Intermediates in influenza induced membrane fusion.

1990 • 253 citations

Identification of the Fusion Peptide of Primate Immunodeficiency Viruses

1989 • 250 citations

Highly efficient neutralization of HIV with recombinant CD4-immunoglobulin molecules

1989 • 217 citations

Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding.

1990 • 214 citations

Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120.

1991 • 211 citations

HIV requires multiple gp120 molecules for CD4-mediated infection

1990 • 179 citations

Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4

1991 • 178 citations

Membrane fusion of Semliki Forest virus in a model system: correlation between fusion kinetics and structural changes in the envelope glycoprotein.

1993 • 176 citations

Fluorescent membrane probes incorporating dipyrrometheneboron difluoride fluorophores

1991 • 166 citations

Kinetics of pH-dependent fusion between influenza virus and liposomes

1985 • 160 citations

Low-pH conformational changes of rabies virus glycoprotein and their role in membrane fusion

1993 • 154 citations

Kinetics of pH-dependent fusion between 3T3 fibroblasts expressing influenza hemagglutinin and red blood cells

1989 • 146 citations

The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits

1992 • 141 citations

Initial stages of influenza hemagglutinin-induced cell fusion monitored simultaneously by two fluorescent events: cytoplasmic continuity and lipid mixing.

1989 • 119 citations

Evaluation of viral membrane fusion assays. Comparison of the octadecylrhodamine dequenching assay with the pyrene excimer assay

1993 • 117 citations

Characterization of stable Chinese hamster ovary cells expressing wild-type, secreted, and glycosylphosphatidylinositol-anchored human immunodeficiency virus type 1 envelope glycoprotein

1993 • 113 citations

Protein lateral mobility as a reflection of membrane microstructure

1993 • 101 citations

Gating kinetics of pH-activated membrane fusion of vesicular stomatitis virus with cells: stopped-flow measurements by dequenching of octadecylrhodamine fluorescence

1990 • 98 citations

Lack of correlation between soluble CD4-induced shedding of the human immunodeficiency virus type 1 exterior envelope glycoprotein and subsequent membrane fusion events

1992 • 87 citations

Expression of membrane-associated and secreted variants of gp160 of human immunodeficiency virus type 1 in vitro and in continuous cell lines

1988 • 84 citations

Characterization of the fusogenic properties of Sendai virus: kinetics of fusion with erythrocyte membranes

1985 • 84 citations

The construction of a highly efficient and versatile set of mammalian expression vectors

1989 • 81 citations

Physicochemical dissociation of CD4-mediated syncytium formation and shedding of human immunodeficiency virus type 1 gp120

1993 • 73 citations

Fusion of Rous sarcoma virus with host cells does not require exposure to low pH

1990 • 66 citations

Macrophage-tropic and T-cell line-adapted chimeric strains of human immunodeficiency virus type 1 differ in their susceptibilities to neutralization by soluble CD4 at different temperatures

1994 • 56 citations

Kinetics of soluble CD4 binding to cells expressing human immunodeficiency virus type 1 envelope glycoprotein

1992 • 50 citations

The adhesion of Chinese hamster cells. I. Effects of temperature, metabolic inhibitors and proteolytic dissection of cell surface macromolecules

1977 • 50 citations

HIV-1 Neutralizing Monoclonal Antibodies Induced by a Synthetic Peptide

1990 • 43 citations

Effects of exposure to low pH on the lateral mobility of influenza hemagglutinin expressed at the cell surface: correlation between mobility inhibition and inactivation

1993 • 41 citations

The carboxy terminus of human immunodeficiency virus type 1 gp160 limits its proteolytic processing and transport in transfected cell lines

1990 • 37 citations

Effects of cytochalasin D on fusion of cells by HVJ (Sendai virus)

1978 • 34 citations

Cell adhesion mediated by CD4 and MHC class II proteins requires active cellular processes.

1993 • 33 citations

Lateral Mobility of Both Envelope Proteins (F and HN) of Sendai Virus in the Cell Membrane Is Essential for Cell-Cell Fusion

1989 • 31 citations

Effects of fusion temperature on the lateral mobility of Sendai virus glycoproteins in erythrocyte membranes and on cell fusion indicate that glycoprotein mobilization is required for cell fusion

1988 • 24 citations