Phosphatidylinositide 3-Kinase Priming Couples c-FLIP to T Cell Activation

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

2000 • 9,712 citations

Apoptosis by Death Factor

1997 • 5,038 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS

1999 • 1,309 citations

Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

1999 • 1,084 citations

The Fas Signaling Pathway: More Than a Paradigm

2002 • 916 citations

Calcium Signaling Mechanisms in T Lymphocytes

2001 • 841 citations

The Role of c-FLIP in Modulation of CD95-induced Apoptosis

1999 • 823 citations

Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt

1999 • 762 citations

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1998 • 704 citations

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

2002 • 685 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

c-FLIPL is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

2002 • 565 citations

The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways

2000 • 556 citations

FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis

2001 • 550 citations

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

1998 • 504 citations

The Long Form of FLIP Is an Activator of Caspase-8 at the Fas Death-inducing Signaling Complex

2002 • 475 citations

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

2003 • 467 citations

Caspase Activation Is Required for T Cell Proliferation

1999 • 462 citations

The Inhibitor of Death Receptor Signaling, Flice-Inhibitory Protein Defines a New Class of Tumor Progression Factors

1999 • 425 citations

Casper Is a FADD- and Caspase-Related Inducer of Apoptosis

1997 • 398 citations

Early Activation of Caspases during T Lymphocyte Stimulation Results in Selective Substrate Cleavage in Nonapoptotic Cells

1999 • 387 citations

Regulation of lymphocyte proliferation and death by flip

2001 • 385 citations

I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

1997 • 372 citations

FLAME-1, a Novel FADD-like Anti-apoptotic Molecule That Regulates Fas/TNFR1-induced Apoptosis

1997 • 339 citations

Immune Escape of Tumors in Vivo by Expression of Cellular Flice-Inhibitory Protein

1999 • 337 citations

CASH, a Novel Caspase Homologue with Death Effector Domains

1997 • 323 citations

DIFFERENTIAL SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

1997 • 273 citations

A Role for FADD in T Cell Activation and Development

1998 • 241 citations

T Lymphocyte Activation Signals for Interleukin-2 Production Involve Activation of MKK6-p38 and MKK7-SAPK/JNK Signaling Pathways Sensitive to Cyclosporin A

1998 • 209 citations

PI 3-kinase: a pivotal pathway in T-cell activation?

1996 • 188 citations

p38 Mitogen-Activated Protein Kinase Mediates Signal Integration of TCR/CD28 Costimulation in Primary Murine T Cells

1999 • 179 citations

Death receptors couple to both cell proliferation and apoptosis

2002 • 139 citations

The Caspase 8 Inhibitor c-FLIP_L Modulates T-Cell Receptor-Induced Proliferation but Not Activation-Induced Cell Death of Lymphocytes

2002 • 137 citations

Mitogen-activated Protein Kinase Kinase Antagonized Fas-associated Death Domain Protein–mediated Apoptosis by Induced FLICE-inhibitory Protein Expression

1998 • 132 citations

PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models

2001 • 129 citations

Death receptors couple to both cell proliferation and apoptosis

2002 • 127 citations

Targeting Rare Populations of Murine Antigen-Specific T Lymphocytes by Retroviral Transduction for Potential Application in Gene Therapy for Autoimmune Disease

2000 • 108 citations

Effects of a dominant interfering mutant of FADD on signal transduction in activated T cells

2001 • 79 citations

Caspases signal not only apoptosis but also antigen-induced activation in cells of the immune system

2003 • 78 citations

p38 Mitogen-activated Protein Kinase Is Involved in Fas Ligand Expression

1999 • 76 citations

CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase.

1995 • 66 citations

CD28-Mediated Costimulation in the Absence of Phosphatidylinositol 3-Kinase Association and Activation

1995 • 61 citations

Multiple Signals Required for Cyclic AMP-Responsive Element Binding Protein (CREB) Binding Protein Interaction Induced by CD3/CD28 Costimulation

2001 • 45 citations

Differential requirement of caspases during naive T cell proliferation

2002 • 29 citations

Inhibition of caspase or FADD function blocks proliferation but not MAP kinase‐activation and interleukin‐2‐production during primary stimulation of T cells

2002 • 28 citations

Inhibition of caspase or FADD function blocks proliferation but not MAP kinase-activation and interleukin-2-production during primary stimulation of T cells

2002 • 24 citations