Diacylglycerol Hydrolysis to Arachidonic Acid Is Necessary for Insulin Secretion from Isolated Pancreatic Islets: Sequential Actions of Diacylglycerol and Monoacylglycerol Lipases

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1988 • 220 citations

Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets.

1988 • 173 citations

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1987 • 157 citations

Potassium selective ion channels in insulin-secreting cells: physiology, pharmacology and their role in stimulus-secretion coupling

1991 • 157 citations

Elusive Proximal Signals of β-Cells for Insulin Secretion

1990 • 151 citations

Ion Channels and Insulin Secretion

1990 • 147 citations

Inhibition of arachidonate release by secretagogue-stimulated pancreatic islets suppresses both insulin secretion and the rise in .beta.-cell cytosolic calcium ion concentration

1993 • 133 citations

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1983 • 129 citations

Rat and human pancreatic islet cells contain a calcium ion independent phospholipase A2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine triphosphate and is specifically localized to islet .beta.-cells

1993 • 123 citations

The role of phospholipid-derived mediators including arachidonic acid, its metabolites, and inositol triphosphate and of intracellular Ca2+ in glucose-induced insulin secretion by pancretic islets

1987 • 119 citations

Control of insulin secretion: a model involving Ca2+, cAMP and diacylglycerol

1990 • 115 citations

Free fatty acid accumulation in secretagogue-stimulated pancreatic islets and effects of arachidonate on depolarization-induced insulin secretion

1991 • 114 citations

The effect of inositol trisphosphate on Ca2+ fluxes in insulin-secreting tumor cells.

1984 • 104 citations

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1990 • 95 citations

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1993 • 85 citations

Secretagogue-induced diacylglycerol accumulation in isolated pancreatic islets. Mass spectrometric characterization of the fatty acyl content indicates multiple mechanisms of generation

1989 • 83 citations

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1990 • 76 citations

Alloxan Uptake by Isolated Rat Islets of Langerhans*

1978 • 75 citations

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1990 • 74 citations

Arachidonic acid release from diacylglycerol in human neutrophils. Translocation of diacylglycerol-deacylating enzyme activities from an intracellular pool to plasma membrane upon cell activation

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The muscarinic receptor subtype in mouse pancreatic B‐cells

1988 • 71 citations

Glucose activates the multifunctional Ca2+/calmodulin-dependent protein kinase II in isolated rat pancreatic islets.

1994 • 69 citations

Glucose-, calcium- and concentration-dependence of acetylcholine stimulation of insulin release and ionic fluxes in mouse islets

1988 • 69 citations

Muscarinic receptor subtypes in rat pancreatic islets: binding and functional studies

1990 • 68 citations

Glucose-induced accumulation of inositol trisphosphates in isolated pancreatic islets. Predominance of the 1,3,4-isomer

1986 • 67 citations

Unmasking of arachidonate-induced insulin release by removal of extracellular calcium

1987 • 63 citations

Protein kinase C in insulin releasing cells

1990 • 63 citations

The digitonin-permeabilized pancreatic islet model. Effect of myo-inositol 1,4,5-trisphosphate on Ca2+ mobilization

1985 • 62 citations

The Pancreatic Islet as Rubik's Cube: Is Phospholipid Hydrolysis a piece of the Puzzle?

1991 • 58 citations

Glucose-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in isolated rat pancreatic islets.

1992 • 58 citations

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1993 • 57 citations

Carbachol stimulation of phospholipase A2 and insulin secretion in pancreatic islets

1992 • 56 citations

Inhibition of phospholipase A2 and insulin secretion in pancreatic islets

1992 • 55 citations

Effects of insulin secretagogues on protein kinase C-catalyzed phosphorylation of an endogenous substrate in isolated pancreatic islets.

1990 • 49 citations

Protein phosphorylation in permeabilized pancreatic islet cells

1985 • 46 citations

Studies of the Ca2+ requirements for glucose- and carbachol-induced augmentation of inositol trisphosphate and inositol tetrakisphosphate accumulation in digitonin-permeabilized islets. Evidence for a glucose recognition site in insulin secretion.

1988 • 45 citations

Effect of glutamate and its analogs on diacylglycerol and monoacylglycerol lipase activities of neuron-enriched cultures

1993 • 44 citations

[48] Assays of phosphoinositide-specific phospholipase C and purification of isozymes from bovine brains

1991 • 40 citations

Transient activation of calcium-dependent phospholipase A2 by insulin secretagogues in isolated pancreatic islets

1993 • 36 citations

Phosphatidylinositol hydrolysis in isolated guinea-pig islets of Langerhans

1983 • 34 citations

Stimulation of mono- and diacylglycerol lipase activities by bradykinin in neural cultures

1990 • 25 citations

G-protein Specificity in Signaling Pathways That Mobilize Calcium in Insulin-Secreting β-TC3 Cells

1993 • 22 citations

Monoglyceride and diglyceride lipases from human platelet microsomes

1988 • 22 citations

Fuel secretagogue stimulation of arachidonic acid accumulation in fresh and cultured pancreatic islets

1993 • 15 citations

Quantitation of the fatty acid composition of phosphatidic acid by capillary gas chromatography electron-capture detection with picomole sensitivity

1994 • 14 citations

Effect of diacylglycerol lipase inhibitor RHC 80267 on pancreatic mouse islet metabolism and insulin secretion

1989 • 10 citations

Arachidonic Acid Mobilizes Intracellular Ca²⁺ in Isletsa

1987 • 8 citations