Free fatty acid accumulation in secretagogue-stimulated pancreatic islets and effects of arachidonate on depolarization-induced insulin secretion

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

Intracellular ATP directly blocks K+ channels in pancreatic B-cells

1984 • 1,199 citations

Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells

1984 • 1,099 citations

Regulation of insulin release by calcium.

1981 • 866 citations

RECEPTORS AND PHOSPHOINOSITIDE-GENERATED SECOND MESSENGERS

1985 • 722 citations

Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: an alternative to radioimmunoassay

1985 • 716 citations

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic ?-cells

1986 • 572 citations

THE SULPHONYLUREA RECEPTOR MAY BE AN ATP-SENSITIVE POTASSIUM CHANNEL

1985 • 507 citations

Pancreatic islet glucose metabolism and regulation of insulin secretion

1986 • 506 citations

Ionization and phase behavior of fatty acids in water: application of the Gibbs phase rule

1988 • 429 citations

Mechanism of glucose-induced insulin secretion.

1980 • 425 citations

[58] Rapid extraction of arachidonic acid metabolites from biological samples using octadecylsilyl silica

1982 • 423 citations

Glucose dependent K+-channels in pancreatic?-cells are regulated by intracellular ATP

1985 • 388 citations

Dissociation of bradykinin-induced prostaglandin formation from phosphatidylinositol turnover in Swiss 3T3 fibroblasts: evidence for G protein regulation of phospholipase A2.

1987 • 375 citations

Insulin release: The fuel hypothesis

1979 • 351 citations

Perifusion of Isolated Rat Islets in Vitro: Participation of the Microtubular System in the Biphasic Release of Insulin

1972 • 311 citations

Family of Glucose-Transporter Genes: Implications for Glucose Homeostasis and Diabetes

1990 • 310 citations

Glucoreceptor mechanisms and the control of insulin release and biosynthesis

1980 • 280 citations

ATP-Sensitive K+ Channels in Pancreatic β-Cells: Spare-Channel Hypothesis

1988 • 220 citations

Evidence for involvement of guanine nucleotide‐binding regulatory proteins in the activation of phospholipases by hormones

1988 • 190 citations

Opposite effects of tolbutamide and diazoxide on 86Rb+ fluxes and membrane potential in pancreatic B cells

1982 • 179 citations

Inhibition of ATP-regulated K+ channels precedes depolarization-induced increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells.

1987 • 173 citations

Polyunsaturated free fatty acids stimulate an increase in cytosolic Ca2+ by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in T cells through a mechanism independent of phosphoinositide turnover.

1990 • 144 citations

A Role for Prostaglandin E in Defective Insulin Secretion and Carbohydrate Intolerance in Diabetes Mellitus

1977 • 144 citations

Suppression of Insulin Release by Galanin and Somatostatin Is Meditated by a G-protein

1989 • 130 citations

[16] A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of langerhans

1983 • 129 citations

Lipoxygenase Pathway in Islet Endocrine Cells. OXIDATIVE METABOLISM OF ARACHIDONIC ACID PROMOTES INSULIN RELEASE

1983 • 125 citations

The role of phospholipid-derived mediators including arachidonic acid, its metabolites, and inositol triphosphate and of intracellular Ca2+ in glucose-induced insulin secretion by pancretic islets

1987 • 119 citations

Dual effects of glucose on the cytosolic Ca²⁺ activity of mouse pancreatic β‐cells

1984 • 119 citations

Insulin Immunoassay by Back-Titration; Some Characteristics of the Technic and the Insulin Precipitant Action of Alcohol

1971 • 91 citations

Glucose-induced phospholipid hydrolysis in isolated pancreatic islets: quantitative effects on the phospholipid content of arachidonate and other fatty acids

1986 • 90 citations

Cloning and functional expression of a human pancreatic islet glucose-transporter cDNA.

1989 • 88 citations

Inhibition of In Vivo Insulin Secretion by Prostaglandin E1

1974 • 78 citations

Receptor-Mediated Adenylate Cyclase—Coupled Mechanism for PGE2 Inhibition of Insulin Secretion in HIT Cells

1987 • 72 citations

Arachidonic acid metabolism in isolated pancreatic islets

1984 • 72 citations

Inhibition of glucose-stimulated insulin release by alpha 2-adrenoceptor activation is parallelled by both a repolarization and a reduction in cytoplasmic free Ca2+ concentration.

1988 • 70 citations

Unmasking of arachidonate-induced insulin release by removal of extracellular calcium

1987 • 63 citations

Characterization of Voltage-Dependent Ca2+ Channels in β-Cell Line

1989 • 63 citations

Arachidonic acid metabolism in isolated pancreatic islets. III. Effects of exogenous lipoxygenase products and inhibitors on insulin secretion

1985 • 60 citations

Glucose increases the synthesis of lipoxygenase-mediated metabolites of arachidonic acid in intact rat islets.

1985 • 59 citations

Arachidonic acid metabolite regulation of insulin secretion

1986 • 49 citations

Eicosanoids as Pluripotential Modulators of Pancreatic Islet Function

1988 • 48 citations

Mechanism of arachidonic acid-induced Ca2+ mobilization from rat liver microsomes

1987 • 40 citations

Arachidonic acid‐induced mobilization of calcium in human neutrophils: evidence for a multicomponent mechanism of action

1989 • 39 citations

Arachidonic acid‐induced release of calcium in permeabilized human neutrophils

1987 • 34 citations

Desensitization of muscle phosphofructokinase to ATP inhibition by removal of a carboxyl-terminal heptadecapeptide.

1987 • 29 citations

Membrane phospholipid turnover as an intermediary step in insulin secretion

1988 • 28 citations

Platelet adenylate cyclase and phospholipase C are affected differentially by ADP-ribosylation. Effects on thrombin-mediated responses

1988 • 28 citations

The glucose sensor in HIT cells is the glucose transporter

1987 • 26 citations

α₂‐Adrenergic inhibition of pancreatic islet glucose utilization is mediated by an inhibitory guanine nucleotide regulatory protein

1987 • 25 citations

Endocrine cells in pancreatic islets of Langerhans are immunoreactive to antibody against guanine nucleotide-binding protein (Go) purified from rat brain

1987 • 22 citations

Is Somatostatin a True Local Inhibitory Regulator of Insulin Secretion?

1984 • 18 citations

Coordinated regulation of free Ca2+ by isolated organelles from a rat insulinoma.

1984 • 18 citations

Relative Importance of Extracellular and Intracellular Ca2+ for Acetylcholine Stimulation of Insulin Release in Mouse Islets

1989 • 16 citations

Arachidonic acid metabolism in isolated pancreatic islets. V. The enantiomeric composition of 12-hydroxy-5,8,10,14-eicosatetraenoic acid indicates synthesis by a 12-lipoxygenase rather than a monooxygenase

1989 • 16 citations

Arachidonic acid elevates cytosolic free calcium concentration in rat anterior pituitary cells

1988 • 13 citations

Effects of the calcium-channel agonist CGP 28392 on insulin secretion from isolated rat islets of Langerhans

1985 • 11 citations

Enhanced glucose-induced insulin release and endogenous Ca2+ ionophoretic activity in neonatal rat islets following islet-activating protein

1983 • 10 citations

Arachidonic Acid Mobilizes Intracellular Ca²⁺ in Isletsa

1987 • 8 citations