Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

2001 • 1,789 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

1999 • 1,207 citations

Pharmacologic Therapy for Type 2 Diabetes Mellitus

1999 • 1,196 citations

Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients

1993 • 1,064 citations

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

1992 • 880 citations

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

1993 • 814 citations

Glucagon-like peptide-1(7–36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns

1993 • 678 citations

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

1997 • 662 citations

Dynamics of β-cell Mass in the Growing Rat Pancreas: Estimation With a Simple Mathematical Model

1995 • 607 citations

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

2000 • 590 citations

Protein Kinase B/Akt Participates in GLUT4 Translocation by Insulin in L6 Myoblasts

1999 • 590 citations

Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor.

1996 • 569 citations

Glucagon-Like Peptides

1998 • 548 citations

Serial killers: ordering caspase activation events in apoptosis

1999 • 468 citations

Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta).

1999 • 439 citations

Transcriptional regulation by MAP kinases

1995 • 431 citations

Glucagon-Like Peptide-1 Induces Cell Proliferation and Pancreatic-Duodenum Homeobox-1 Expression and Increases Endocrine Cell Mass in the Pancreas of Old, Glucose-Intolerant Rats

2000 • 427 citations

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

1999 • 405 citations

Apoptosis Participates in the Remodeling of the Endocrine Pancreas in the Neonatal Rat*

1997 • 399 citations

β-Cell Mass Dynamics in Zucker Diabetic Fatty Rats

2001 • 374 citations

Glucagon-Like Peptide-1 and Exendin-4 Stimulate β-Cell Neogenesis in Streptozotocin-Treated Newborn Rats Resulting in Persistently Improved Glucose Homeostasis at Adult Age

2001 • 367 citations

Exendin-4 Decelerates Food Intake, Weight Gain, and Fat Deposition in Zucker Rats

2000 • 295 citations

Life and Death of the Pancreatic β Cells

2000 • 286 citations

Protein kinase B (PKB/Akt) – a key regulator of glucose transport?

2001 • 274 citations

The U.K. Prospective Diabetes Study: A review

1998 • 266 citations

Regulation of beta-cell mass by hormones and growth factors.

2001 • 236 citations

Glucose, Other Secretagogues, and Nerve Growth Factor Stimulate Mitogen-activated Protein Kinase in the Insulin-secreting β-Cell Line, INS-1

1995 • 222 citations

Pancreatic Glucagon-Like Peptide-1 Receptor Couples to Multiple G Proteins and Activates Mitogen-Activated Protein Kinase Pathways in Chinese Hamster Ovary Cells*

1999 • 202 citations

Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations

1999 • 192 citations

Glucagon-like peptides

1998 • 191 citations

Glucagon-Like Peptide 1(7-36) Amide Stimulates Exocytosis in Human Pancreatic β-Cells by Both Proximal and Distal Regulatory Steps in Stimulus-Secretion Coupling

1998 • 188 citations

Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model

1995 • 162 citations

Initiation of Increased Pancreatic Islet Growth in Young Normoglycemic Mice (Umeå +/?)*

1999 • 153 citations

Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor

1996 • 149 citations

Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion

1997 • 141 citations

The genetics of diabetes susceptibility in mice

1989 • 134 citations

Effects of Glucagon-Like Peptide-1 on Islet Function and Insulin Sensitivity in Noninsulin-Dependent Diabetes Mellitus¹

1997 • 129 citations

Apoptosis Participates in the Remodeling of the Endocrine Pancreas in the Neonatal Rat

1997 • 120 citations

Glucagon-Like Peptide-1 Induces Cell Proliferation and Pancreatic-Duodenum Homeobox-1 Expression and Increases Endocrine Cell Mass in the Pancreas of Old, Glucose-Intolerant Rats

2000 • 117 citations

Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs.

1999 • 114 citations

Differential Activation of Protein Kinase B and p70S6K by Glucose and Insulin-like Growth Factor 1 in Pancreatic β-Cells (INS-1)

2001 • 110 citations

Effects of Glucagon-Like Peptide-1 on Islet Function and Insulin Sensitivity in Noninsulin-Dependent Diabetes Mellitus

1997 • 98 citations

IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication

2000 • 98 citations

Rapid Activation and Nuclear Translocation of Mitogen-activated Protein Kinases in Response to Physiological Concentration of Glucose in the MIN6 Pancreatic β Cell Line

1998 • 80 citations

Exendin-4 Decelerates Food Intake, Weight Gain, and Fat Deposition in Zucker Rats

2000 • 77 citations

Chromogranin A: a multipurpose prohormone?

1994 • 61 citations

Integrative Mitogenic Role of Protein Kinase B/Akt in β‐Cells

2000 • 59 citations

Phosphatidylinositol 3-Kinase Signaling to Akt Mediates Survival in Isolated Canine Islets of Langerhans

2000 • 55 citations

Pancreatic Glucagon-Like Peptide-1 Receptor Couples to Multiple G Proteins and Activates Mitogen-Activated Protein Kinase Pathways in Chinese Hamster Ovary Cells

1999 • 51 citations

Protein Kinase B Is Expressed in Pancreatic β Cells and Activated upon Stimulation with Insulin-like Growth Factor I

1998 • 50 citations

Regulation of glucose transporters and hexose uptake in 3T3-L1 adipocytes: glucagon-like peptide-1 and insulin interactions

1997 • 48 citations

Gastric Inhibitory Polypeptide Activates MAP Kinase through the Wortmannin-Sensitive and -Insensitive Pathways

1997 • 48 citations

Oral delivery of glucagon-like peptide-1 in a modified polymer preparation normalizes basal glycaemia in diabetic db / db mice

2000 • 45 citations

Glucagon-like peptide-1(7-36)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: in vivo and in vitro studies

1997 • 38 citations