Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations

U.K. Prospective Diabetes Study 16: Overview of 6 Years' Therapy of Type II Diabetes: A Progressive Disease

1995 • 1,880 citations

Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans.

1998 • 1,338 citations

Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients

1993 • 1,064 citations

Antidiabetogenic Effect of Glucagon-like Peptide-1 (7–36)amide in Normal Subjects and Patients with Diabetes Mellitus

1992 • 858 citations

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

1993 • 814 citations

Cloning and Functional Expression of the Human Islet GLP-1 Receptor: Demonstration That Exendin-4 Is an Agonist and Exendin-(9–39) an Antagonist of the Receptor

1993 • 533 citations

Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients.

1996 • 460 citations

Cardiac and Glycemic Benefits of Troglitazone Treatment in NIDDM

1997 • 372 citations

The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7–37) in normal and diabetic subjects

1994 • 309 citations

Insulinotropic Action of Glucagonlike Peptide-I-(7–37) in Diabetic and Nondiabetic Subjects

1992 • 282 citations

Pharmacokinetic, insulinotropic, and glucagonostatic properties of GLP-1 [7?36 amide] after subcutaneous injection in healthy volunteers. Dose-response-relationships

1995 • 199 citations

Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats

1997 • 188 citations

Reduction of the Incretin Effect in Rats by the Glucagon-Like Peptide 1 Receptor Antagonist Exendin (9–39) Amide

1995 • 180 citations

Dose—Response Relationships

1987 • 175 citations

Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats.

1997 • 174 citations

Tissue-specific Expression of Unique mRNAs That Encode Proglucagon-derived Peptides or Exendin 4 in the Lizard

1997 • 165 citations

Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39) amide

1995 • 53 citations

Age-dependent reduction in insulin secretion and insulin mRNA in isolated islets from rats

1995 • 50 citations

Overexpression of glucagon-like peptide-1 receptor in an insulin-secreting cell line enhances glucose responsiveness

1997 • 34 citations

Pharmacokinetic, insulinotropic, and glucagonostatic properties of GLP-1 [7?36 amide] after subcutaneous injection in healthy volunteers. Dose-response-relationships

1995 • 22 citations

The Effects of GLP-1 on Insulin Release in Young and Old Rats in the Fasting State and During an Intravenous Glucose Tolerance Test

1997 • 17 citations