Telomerase is strongly activated in hepatocellular carcinoma but not in chronic hepatitis and cirrhosis

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Structure and function of telomeres

1991 • 3,524 citations

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

1985 • 3,331 citations

Primary carcinoma of the liver.A study of 100 cases among 48,900 necropsies

1954 • 2,755 citations

A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.

1988 • 2,281 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena

1978 • 1,003 citations

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.

1993 • 743 citations

Correlating telomerase activity levels with human neuroblastoma outcomes

1995 • 631 citations

Telomerase activity in normal leukocytes and in hematologic malignancies

1995 • 619 citations

Telomerase Activity in Small-Cell and Non-Small-Cell Lung Cancers

1995 • 447 citations

Telomerase Activity in Human Breast Tumors

1996 • 440 citations

Telomerase activity in gastric cancer.

1995 • 433 citations

Telomerase activity associated with acquisition of malignancy in human colorectal cancer.

1995 • 361 citations

Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes

1994 • 360 citations

Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas.

1995 • 313 citations

Telomerase activity is detected in pancreatic cancer but not in benign tumors.

1997 • 208 citations

Telomerase expression in respiratory epithelium during the multistage pathogenesis of lung carcinomas.

1997 • 173 citations

Telomerase activity and telomere length in hepatocellular carcinoma and chronic liver disease

1997 • 160 citations

Telomere Shortening in Chronic Liver Diseases

1995 • 142 citations

Telomerase as a tool for the differential diagnosis of human hepatocellular carcinoma

1996 • 83 citations

Telomere changes in human hepatocellular carcinomas and hepatitis virus infected noncancerous livers

1996 • 41 citations

Application of bradford's protein assay to chick brain subcellular fractions

1980 • 27 citations

Is staging of cancer of value?

1983 • 18 citations

Telomere changes in human hepatocellular carcinomas and hepatitis virus infected noncancerous livers

1996 • 16 citations

Purification and cloning of glyoxalase II from rat liver

1998 • 13 citations

Telomerase as a tool for the differential diagnosis of human hepatocellular carcinoma

1996 • 11 citations