Relationship between hepatocyte proliferative activity and liver functional reserve in human cirrhosis

Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some, neoplasms

1990 • 1,454 citations

Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites.

1987 • 945 citations

Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA) structural conservation and the detection of a nucleolar form

1990 • 736 citations

Identity of the proliferating cell nuclear antigen and cyclin

1984 • 702 citations

Cell cycle-dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: subdivision of S phase.

1985 • 640 citations

Analysis of proliferative grade using anti-PCNA/cyclin monoclonal antibodies in fixed, embedded tissues. Comparison with flow cytometric analysis.

1989 • 582 citations

Regulation of Proliferating Cell Nuclear Antigen during the Cell Cycle

1989 • 447 citations

Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat.

1988 • 424 citations

The Transjugular Intrahepatic Portosystemic Stent–Shunt Procedure for Refractory Ascites

1995 • 422 citations

The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, andmdr gene expression in colorectal cancer

1993 • 415 citations

Inhibitory effect of transforming growth factor-β on DNA synthesis of adult rat hepatocytes in primary culture

1985 • 325 citations

Inhibition of DNA synthesis in rat hepatocytes by platelet-derived type beta transforming growth factor.

1986 • 317 citations

Cyclin/PCNA immunostaining as an alternative to tritiated thymidine pulse labelling for marking S phase cells in paraffin sections from animal and human tissues

1989 • 295 citations

Levels of the human hepatocyte growth factor in serum of patients with various liver diseases determined by an enzyme-linked immunosorbent assay

1991 • 293 citations

Monoclonal antibodies to a nuclear protein (PCNA/cyclin) associated with DNA replication

1987 • 268 citations

The assessment of proliferating cell nuclear antigen (PCNA) immunostaining in primary gastrointestinal lymphomas and its relationship to histological grade, S + G2 + M phase fraction (flow cytometric analysis) and prognosis

1991 • 220 citations

Transforming growth factor—beta 1 (TGF-β1) and TGF-β1 receptors in normal, cirrhotic, and neoplastic human livers

1995 • 219 citations

Plasma transforming growth factor-β1 in patients with hepatocellular carcinoma. Comparison with chronic liver diseases

1994 • 215 citations

Serum hepatocyte growth factor levels in liver diseases: Clinical implications

1995 • 202 citations

Transforming growth factors.

1985 • 168 citations

Transjugular intrahepatic portosystemic shunts for refractory ascites: Assessment of clinical and hormonal response and renal function

1995 • 154 citations

Antibodies to proliferating cell nuclear antigen as S-phase probes in flow cytometric cell cycle analysis.

1991 • 152 citations

Hepatocyte regeneration in acute fulminant and nonfulminant hepatitis: A study of proliferating cell nuclear antigen expression

1992 • 126 citations

Immunohistochemical detection of transforming growth factor-β1 in fibrotic liver diseases

1991 • 111 citations

Significance of hepatocellular proliferation in the development of hepatocellular carcinoma from anti-hepatitis C virus-positive cirrhotic patients

1994 • 98 citations

Prognostic significance of proliferating cell nuclear antigen expression in colorectal cancer

1993 • 95 citations

The assessment of proliferating cell nuclear antigen immunohistochemical staining in small hepatocellular carcinoma and its relationship to histologic characteristics and prognosis

1993 • 94 citations

Prognostic significance of proliferating cell nuclear antigen expression in hepatocellular carcinoma

1994 • 93 citations

Proliferating cell nuclear antigen counts in formalin-fixed paraffin-embedded tissue correlate with Ki-67 in fresh tissue.

1992 • 84 citations

The Eck Fistula Rat: Definition of an Experimental Model*^,**

1972 • 80 citations

Analysis of proliferating hepatocytes using a monoclonal antibody against proliferating cell nuclear antigen/cyclin in embedded tissues from various liver diseases fixed in formaldehyde.

1992 • 79 citations

Analysis of proliferative activity using anti-proliferating cell nuclear antigen antibody in gastric cancer tissue specimens obtained by endoscopic biopsy

1993 • 74 citations

Hepatocyte proliferation as an indicator of outcome in acute alcoholic hepatitis

1994 • 74 citations

Immunolocalization of regenerating cells after submassive liver necrosis using PCNA staining

1992 • 73 citations

Cell proliferative activity in adenomatous hyperplasia of the liver and small hepatocellular carcinoma. An immunohistochemical study demonstrating proliferating cell nuclear antigen

1992 • 69 citations

Proliferating cell nuclear antigen: a marker for hepatocellular proliferation in rodents.

1993 • 66 citations

Increased risk of hepatocellular carcinoma development in patients with cirrhosis and with high hepatocellular proliferation

1994 • 66 citations

Proliferating cell nuclear antigen in hepatocellular carcinoma and small cell liver dysplasia

1993 • 66 citations

Development of hepatocellular carcinoma associated with increases in DNA synthesis in the surrounding cirrhosis

1992 • 63 citations

Proliferating cell nuclear antigen (PCNA) expression in regenerating rat liver after partial hepatectomy

1994 • 57 citations

Biology of Disease Regulation of Liver Growth: Protooncogenes and Transforming Growth Factors

1990 • 53 citations

Intranuclear co-location of newly replicated DNA and PCNA by simultaneous immunofluorescent labelling and confocal microscopy in MCF-7 cells

1992 • 51 citations

Proliferating cell nuclear antigen expression in normal, regenerative, and neoplastic liver: A fine-needle aspiration cytology and biopsy study

1993 • 47 citations

Difference in thein vitro uptake of bromodeoxyuridine between liver cirrhosis with and without hepatocellular carcinoma

1989 • 39 citations

Proliferating cell nuclear antigen labeling index of preoperative biopsy specimens in gastric carcinoma with special reference to prognosis

1994 • 38 citations

Partial portacaval shunt: renaissance of an old concept.

1992 • 36 citations

Detection of proliferating hepatocytes by immunohistochemical staining for proliferating cell nuclear antigen (PCNA) in patients with acute hepatic failure

1992 • 34 citations

S-Phase cells in diseased human liver determined by anin Vitro BrdU-anti-BrdU method

1988 • 33 citations

Immunohistochemical analysis of S‐phase cells in normal human and rat liver by PC10 monoclonal antibody

1994 • 30 citations

Transjugular Intrahepatic Portosystemic Stent Shunt as a Rescue Treatment after Sclerotherapy Failure in Variceal Bleeding

1994 • 30 citations

Assessment of liver function by the aminopyrine breath test.

1983 • 27 citations

Argyrophilic Nucleolar Organizer Regions and Alpha-fetoprotein in Adenomatous Hyperplasia in Human Cirrhotic Livers

1991 • 25 citations

Regulating factors of liver regeneration after hepatectomy

1994 • 25 citations

Immunocytochemical identification of proliferative hepatocytes using monoclonal antibody to proliferating cell nuclear antigen (PCNA/cyclin). Comparison with immunocytochemical staining for DNA polymerase-alpha.

1992 • 21 citations

DNA synthesis activities of hepatocytes from noncancerous cirrhotic tissue and of hepatocellular carcinoma (HCC) cells from cancerous tissue can predict the survival of hepatectomized patients with HCC

1993 • 20 citations

Increased uptake of bromodeoxyuridine by hepatocytes from early stage of primary biliary cirrhosis

1991 • 19 citations

Hepatic [14C]aminopyrine demethylation capacity after portocaval shunting

1993 • 17 citations

Immunohistochemical detection of proliferating cell nuclear antigen in hepatocellular carcinoma: Relationship to histological grade

1993 • 15 citations

Retrospective assessment of liver cell proliferation via PCNA: a comparison with tritiated thymidine

1994 • 14 citations

Clinicopathological study of proliferating cell nuclear antigen (PCNA) of hepatocytes in primary biliary cirrhosis

1994 • 12 citations

S phase duration measurement by combined PCNA/cyclin immunostaining and radioautography after a single pulse-labelling with 3H-thymidine

1990 • 9 citations

Cell Proliferation and Cell Death in the Liver: Patterns, Mechanisms and Measurements

1994 • 1 citations

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