Chronic Heart Failure and the Immune System

Should We STOP Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Advanced Kidney Disease?

2016 • 11,500 citations

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

Heart Disease: A Textbook of Cardiovascular Medicine.

1984 • 4,239 citations

Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)

1988 • 3,818 citations

Cellular and Molecular Immunology

1994 • 3,469 citations

The Triad of Sleep Apnea, Hypertension, and Chronic Kidney Disease: A Spectrum of Common Pathology

2016 • 3,202 citations

Cellular and Molecular Immunology

1992 • 2,768 citations

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

Endothelial-Leukocyte Adhesion Molecules

1993 • 1,324 citations

Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)

1996 • 1,203 citations

Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines.

1985 • 1,110 citations

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

1990 • 1,066 citations

Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart

1996 • 993 citations

Cytokines and Cytokine Receptors in Advanced Heart Failure

2001 • 985 citations

Endotoxin and immune activation in chronic heart failure: a prospective cohort study

1999 • 851 citations

Pathophysiologically Relevant Concentrations of Tumor Necrosis Factor-α Promote Progressive Left Ventricular Dysfunction and Remodeling in Rats

1998 • 810 citations

THE ROLE OF ENDOTHELIAL CELLS IN INFLAMMATION

1990 • 808 citations

Hormonal Changes and Catabolic/Anabolic Imbalance in Chronic Heart Failure and Their Importance for Cardiac Cachexia

1997 • 801 citations

Plasma Cytokine Parameters and Mortality in Patients With Chronic Heart Failure

2000 • 778 citations

Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death.

1996 • 742 citations

Hypoxia induces endothelin gene expression and secretion in cultured human endothelium.

1991 • 691 citations

Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.

1993 • 656 citations

Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure.

1992 • 653 citations

Requirement of Mip-1α for an Inflammatory Response to Viral Infection

1995 • 636 citations

The Neurohumoral Axis in Congestive Heart Failure

1984 • 612 citations

Endothelin in human congestive heart failure.

1994 • 598 citations

Interleukin-6 Spillover in the Peripheral Circulation Increases With the Severity of Heart Failure, and the High Plasma Level of Interleukin-6 Is an Important Prognostic Predictor in Patients With Congestive Heart Failure

1998 • 556 citations

Tumor Necrosis Factor Soluble Receptors in Patients With Various Degrees of Congestive Heart Failure

1995 • 534 citations

Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids.

1988 • 519 citations

Endothelin is a potent mitogen for rat vascular smooth muscle cells

1989 • 509 citations

Circulating Levels of Cytokines and Their Endogenous Modulators in Patients With Mild to Severe Congestive Heart Failure Due to Coronary Artery Disease or Hypertension

1996 • 505 citations

Plasma endothelin in chronic heart failure.

1992 • 494 citations

Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness.

1989 • 493 citations

Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy

1999 • 462 citations

Endothelin-A Receptor Antagonist–Mediated Vasodilatation Is Attenuated by Inhibition of Nitric Oxide Synthesis and by Endothelin-B Receptor Blockade

1998 • 459 citations

Safety and Efficacy of a Soluble P75 Tumor Necrosis Factor Receptor (Enbrel, Etanercept) in Patients With Advanced Heart Failure

1999 • 397 citations

Elevated soluble CD14 receptors and altered cytokines in chronic heart failure

1997 • 393 citations

Myocardial Infarction and Apoptosis After Myocardial Ischemia and Reperfusion

1998 • 390 citations

Results of Targeted Anti–Tumor Necrosis Factor Therapy With Etanercept (ENBREL) in Patients With Advanced Heart Failure

2001 • 386 citations

Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy

1996 • 365 citations

Elevated Circulating Levels of C-C Chemokines in Patients With Congestive Heart Failure

1998 • 357 citations

Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium.

1992 • 357 citations

Heart Disease: A Textbook of Cardiovascular Medicine.

1991 • 356 citations

Prognostic impact of big endothelin-1 plasma concentrations compared with invasive hemodynamic evaluation in severe heart failure

1996 • 349 citations

Increased concentrations of tumour necrosis factor in "cachectic" patients with severe chronic heart failure.

1991 • 348 citations

Hypoxia-mediated induction of endothelial cell interleukin-1 alpha. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface.

1992 • 341 citations

Immunomodulating Therapy With Intravenous Immunoglobulin in Patients With Chronic Heart Failure

2001 • 337 citations

Immunoglobulin Adsorption in Patients With Idiopathic Dilated Cardiomyopathy

2000 • 333 citations

The Management of Chronic Heart Failure

1996 • 332 citations

Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor α can be modulated by anti-tumor necrosis factor α therapy

2000 • 319 citations

Familial dilated cardiomyopathy

1999 • 307 citations

Increased endothelin in experimental heart failure.

1990 • 288 citations

Endothelin ET_A and ET_B receptors mediate vascular smooth muscle contraction

1992 • 286 citations

Hemodynamic effects of immunoadsorption and subsequent immunoglobulin substitution in dilated cardiomyopathy

2000 • 275 citations

Upregulation of cell adhesion molecules and the presence of low grade inflammation in human chronic heart failure

1997 • 268 citations

Endothelin stimulated by angiotensin II augments contractility of spontaneously hypertensive rat resistance arteries.

1992 • 264 citations

The adhesion molecules of inflammation

1993 • 257 citations

Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload.

1994 • 252 citations

Autoantibodies Activating Human β ₁ -Adrenergic Receptors Are Associated With Reduced Cardiac Function in Chronic Heart Failure

1999 • 251 citations

Decreased Expression of Tumor Necrosis Factor-α in Failing Human Myocardium After Mechanical Circulatory Support

1999 • 250 citations

Effect of beta-blockers on circulating levels of inflammatory and anti-inflammatory cytokines in patients with dilated cardiomyopathy

2001 • 242 citations

Circulating concentrations of proinflammatory cytolcines in mild or moderate heart failure secondary to ischemic or idiopathic dilated cardiomyopathy

1996 • 241 citations

Effect of high- versus low-dose angiotensin converting enzyme inhibition on cytokine levels in chronic heart failure

1999 • 239 citations

Enalapril improves systemic and renal hemodynamics and allows regression of left ventricular mass in essential hypertension

1984 • 239 citations

Structural remodeling in hypertensive heart disease and the role of hormones.

1994 • 237 citations

Metabolic effects of cachectin/tumor necrosis factor are modified by site of production. Cachectin/tumor necrosis factor-secreting tumor in skeletal muscle induces chronic cachexia, while implantation in brain induces predominantly acute anorexia.

1990 • 228 citations

Pathophysiological correlates of increased serum tumor necrosis factor in patients with congestive heart failure. Relation to nitric oxide-dependent vasodilation in the forearm circulation.

1994 • 219 citations

Angiotensin II type 1 receptor antagonist decreases plasma levels of tumor necrosis factor alpha, interleukin-6 and soluble adhesion molecules in patients with chronic heart failure

2000 • 196 citations

Angiotensin II Increases Vascular and Renal Endothelin-1 and Functional Endothelin Converting Enzyme Activityin Vivo:Role of ETAReceptors for Endothelin Regulation

1997 • 194 citations

Interleukin-1 beta induces cardiac myocyte growth but inhibits cardiac fibroblast proliferation in culture.

1995 • 193 citations

Activation of JAK-STAT and MAP Kinases by Leukemia Inhibitory Factor Through gp130 in Cardiac Myocytes

1996 • 192 citations

Increased Plasma Concentrations of Endothelin in Congestive Heart Failure in Humans

1992 • 191 citations

Impaired Inflammatory Responses in the Reverse Arthus Reaction Through Genetic Deletion of the C5a Receptor

1997 • 191 citations

Systemic inflammation in patients with heart failure

1998 • 182 citations

The role of inflammatory mediators in chronic heart failure: cytokines, nitric oxide, and endothelin-1

2000 • 176 citations

Tumour necrosis factor alpha in severe congestive cardiac failure.

1993 • 172 citations

Prognostic value of plasma soluble intercellular adhesion molecule-1 and endothelin-1 concentration in patients with chronic congestive heart failure

1995 • 169 citations

Increased Expression of Interleukin-1β and Monocyte Chemotactic and Activating Factor/Monocyte Chemoattractant Protein-1 in the Hypertrophied and Failing Heart With Pressure Overload

1997 • 163 citations

Endothelin-1 Release from Endothelial Cells in Culture Is Elevated Both Acutely and Chronically by Short Periods of Mechanical Stretch

1994 • 160 citations

Soluble Tumor Necrosis Factor Receptor Abrogates Myocardial Inflammation but Not Hypertrophy in Cytokine-Induced Cardiomyopathy

2000 • 159 citations

Frequency and specificity of antiheart antibodies in patients with dilated cardiomyopathy detected using SDS-PAGE and western blotting

1993 • 158 citations

Vesnarinone, a new inotropic agent, inhibits cytokine production by stimulated human blood from patients with heart failure.

1994 • 156 citations

Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future?

2001 • 155 citations

CXC-chemokines, a new group of cytokines in congestive heart failure — possible role of platelets and monocytes

2000 • 150 citations

Tumor Necrosis Factor Antagonism With Etanercept Improves Systemic Endothelial Vasoreactivity in Patients With Advanced Heart Failure

2001 • 147 citations

Interleukin-1 in Myocardium and Coronary Arteries of Patients with Dilated Cardiomyopathy

1998 • 136 citations

Acute pulmonary alveolar hypoxia increases lung and plasma endothelin-1 levels in conscious rats

1991 • 132 citations

Expression of proinflammatory cytokines in the failing human heart: comparison of recent-onset and end-stage congestive heart failure

2000 • 130 citations

Cytokine-induced release of endothelin-1 from porcine renal epithelial cell line

1990 • 122 citations

Hypoxia Induces a Human Macrophage Cell Line to Release Tumor Necrosis Factor-α and Its Soluble Receptors in Vitro

1993 • 121 citations

THE ROLE OF CYTOKINES IN THE FAILING HUMAN HEART

1998 • 120 citations

Angiotensin-converting-enzyme inhibitors suppress synthesis of tumour necrosis factor and interleukin 1 by human peripheral blood mononuclear cells

1995 • 120 citations

Do ACE‐inhibitors suppress tumour necrosis factor‐α production in advanced chronic renal failure?

1999 • 119 citations

Prognostic value of serum cytokines in patients with congestive heart failure

2000 • 118 citations

Mechanisms of pulmonary edema induced by tumor necrosis factor-alpha.

1990 • 116 citations

Role of Cytokines in the Mechanism of Action of Amlodipine: The PRAISE Heart Failure Trial

1997 • 114 citations

LEUCOCYTE ADHESION TO CELLS IN IMMUNE AND INFLAMMATORY RESPONSES

1989 • 111 citations

Levels of Circulating Adhesion Molecules in Congestive Heart Failure and After Heart Transplantation

1998 • 102 citations

The effect of renin–angiotensin system inhibitors on pro‐ and anti‐inflammatory cytokine production

1998 • 98 citations

Elevated interleukin-6 levels in patients with asymptomatic left ventricular systolic dysfunction

2001 • 96 citations

Anti–Tumor Necrosis Factor-α Antibody Limits Heart Failure in a Transgenic Model

2001 • 94 citations

Serum interleukin-6 in congestive heart failure secondary to idiopathic dilated cardiomyopathy

1998 • 93 citations

Increased levels of serum neoprotein and decreased production of neutrophil superoxide anions in chronic heart failure with elevated levels of tumor necrosis factor-alpha

1993 • 90 citations

Soluble TNF binding proteins modulate the negative inotropic properties of TNF-alpha in vitro

1995 • 90 citations

Hypoxia increases endothelin release in bovine endothelial cells in culture, but epinephrine, norepinephrine, serotonin, histamine and angiotensin II do not

1990 • 90 citations

Angiotensin converting enzyme inhibition and ventricular remodeling in heart failure

1988 • 90 citations

Modulation of beta1-adrenoceptor activity by domain-specific antibodies and heart failure–associated autoantibodies

2000 • 89 citations

Angiotensin converting enzyme inhibitors suppress production of tumor necrosis factor-α in vitro and in vivo

1997 • 88 citations

Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis

1999 • 87 citations

Role of endothelin in the exercise intolerance of chronic heart failure

1995 • 86 citations

Cytokine stimulated endothelin release from endothelial cells

1991 • 86 citations

Endothelin-1 and its binding sites are upregulated in pressure overload cardiac hypertrophy

1995 • 85 citations

Cytokines and Heart Failure

1999 • 82 citations

Increased cardiac expression of endothelin-1 mRNA in ischemic heart failure in rats

1997 • 73 citations

Beneficial effects of metoprolol treatment in congestive heart failure. Reversal of sympathetic-induced alterations of immunologic function.

1994 • 66 citations

Effect of metoprolol on cytokine levels in chronic heart failure—A substudy in the Metoprolol Controlled-Release Randomised Intervention Trial in Heart Failure (MERIT-HF)

2001 • 62 citations

Proinflammatory cytokines, measured in a mixed population on arrival in the emergency department, are related to mortality and severity of disease

1997 • 60 citations

Serum complement activation in congestive heart failure

2001 • 53 citations

Life and Death in the Cardiovascular System

1997 • 52 citations

Production of endothelin by cultured porcine endothelial cells: modulation by adrenaline

1989 • 52 citations

The changes of circulating tumor necrosis factor levels in patients with congestive heart failure influenced by therapy

1999 • 45 citations

Cytokine and Lipopolysaccharide Stimulation of Endothelin-1 Release from Human Internal Mammary Artery and Saphenous Vein Smooth-Muscle Cells

1998 • 38 citations

Transcardiac extraction of circulating endothelin-1 across the failing heart

2000 • 31 citations

Immunoadsorption in Dilated Cardiomyopathy

2000 • 31 citations

The activated immune system and the renin–angiotensin–aldosterone system in congestive heart failure

1998 • 25 citations

Left Ventricle and Arteries

2001 • 22 citations

Interleukin-2 enhances the release of endothelin-1 from the rat mesenteric artery

1991 • 22 citations

Cardiac dysfunction caused by recombinant human C5A anaphylatoxin: mediation by histamine, adenosine and cyclooxygenase arachidonate metabolites.

1990 • 21 citations

Stimulated Cellular Immune System in Patients with Congestive Heart Failure

1993 • 18 citations

Isometric Handgrip Exercise Increases Endothelin-1 Plasma Levels in Patients With Chronic Congestive Heart Failure

1997 • 16 citations

Soluble antiapoptotic molecules and immune activation in chronic heart failure and unstable angina pectoris.

2000 • 12 citations

Isolated Left Ventricular Filling Abnormalities May Predict Interleukin-2-Induced Cardiovascular Toxicity

1996 • 10 citations

Increased frequency of organ‐specific cardiac antibodies in healthy relatives of patients with dilated cardiomyopathy: Evidence for autoimmunity in polish families

1996 • 6 citations

Endothelin-1 in heart failure: does it play a role?

1998 • 2 citations