Cells and Cytokines in Resistance to Toxoplasma gondii

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

Interferon-γ: the Major Mediator of Resistance Against Toxoplasma gondii

1988 • 1,150 citations

Natural and synthetic non-peptide antigens recognized by human γδ T cells

1995 • 974 citations

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

1993 • 837 citations

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

1993 • 792 citations

IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

1992 • 709 citations

Stimulation of Human γδ T Cells by Nonpeptidic Mycobacterial Ligands

1994 • 685 citations

Expression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytes

1988 • 663 citations

CDlb restricts the response of human CD4−8−T lymphocytes to a microbial antigen

1992 • 577 citations

Specificity and function of T cells bearing γδ receptors

1988 • 570 citations

Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii.

1992 • 563 citations

Isolation of CD4-CD8-mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid

1989 • 543 citations

Stimulation of a major subset of lymphocytes expressing T cell receptor γδ by an antigen derived from mycobacterium tuberculosis

1989 • 491 citations

Different roles of αβ and γδ T cells in immunity against an intracellular bacterial pathogen

1993 • 426 citations

IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity.

1992 • 422 citations

Role of cytokines in determining T-lymphocyte function

1994 • 396 citations

Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha

1994 • 374 citations

Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-alpha and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation.

1993 • 345 citations

A large fraction of human peripheral blood gamma/delta + T cells is activated by Mycobacterium tuberculosis but not by its 65-kD heat shock protein.

1990 • 331 citations

Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta).

1991 • 309 citations

Subthreshold synaptic Ca2+ signalling in fine dendrites and spines of cerebellar Purkinje neurons

1995 • 309 citations

Toxoplasma gondii induces a T-independent IFN-gamma response in natural killer cells that requires both adherent accessory cells and tumor necrosis factor-alpha.

1993 • 271 citations

IL-1 beta is required for IL-12 to induce production of IFN-gamma by NK cells. A role for IL-1 beta in the T cell-independent mechanism of resistance against intracellular pathogens.

1995 • 253 citations

Regulation of NK cell functions by TGF-beta 1.

1995 • 241 citations

Class I MHC genes and CD8+ T cells determine cyst number in Toxoplasma gondii infection.

1990 • 230 citations

Transforming growth factor beta as a virulence mechanism for Leishmania braziliensis.

1993 • 217 citations

Definitive identification of a gene that confers resistance against Toxoplasma cyst burden and encephalitis.

1995 • 179 citations

The primary response of human gamma/delta + T cells to Mycobacterium tuberculosis is restricted to V gamma 9-bearing cells.

1991 • 173 citations

Human TCR-gamma+/delta+, CD8+ T lymphocytes recognize tetanus toxoid in an MHC-restricted fashion.

1989 • 170 citations

Murine CD8+ cytotoxic T lymphocytes lyse Toxoplasma gondii-infected cells.

1991 • 159 citations

Transforming growth factor‐β inhibits interleukin‐12‐induced production of interferon‐γ by natural killer cells: A role for transforming growth factor‐β in the regulation of T cell‐independent resistance to Toxoplasma gondii

1995 • 149 citations

Induction of murine peritoneal gamma/delta T cells and their role in resistance to bacterial infection.

1993 • 144 citations

Toxoplasmosis in Patients with Cancer

1993 • 141 citations

A gene(s) within the H-2D region determines the development of toxoplasmic encephalitis in mice.

1991 • 141 citations

A protective role for endogenous tumor necrosis factor in Toxoplasma gondii infection

1992 • 133 citations

In vivo recombinant interleukin 2 administration enhances survival against a lethal challenge with Toxoplasma gondii.

1985 • 131 citations

A role for gamma delta + T cells during experimental infection of mice with Leishmania major.

1993 • 104 citations

Lymphocytes bearing the gamma delta T-cell receptor in acute toxoplasmosis.

1992 • 98 citations

Role of the mononuclear phagocyte as an antigen-presenting cell for human gamma delta T cells activated by live Mycobacterium tuberculosis

1992 • 95 citations

Plasmodium falciparum merozoites primarily stimulate the V_γ9 subset of human γ/δ T cells

1991 • 93 citations

Cytokine mRNA in the central nervous system of SCID mice infected with Toxoplasma gondii: importance of T-cell-independent regulation of resistance to T. gondii

1993 • 88 citations

Infection of murine macrophages with Toxoplasma gondii is associated with release of transforming growth factor beta and downregulation of expression of tumor necrosis factor receptors

1993 • 77 citations

A lectin-binding, protease-resistant mycobacterial ligand specifically activates V gamma 9+ human gamma delta T cells.

1992 • 77 citations

MHC class I gene(s) in the D/L region but not the TNF-alpha gene determines development of toxoplasmic encephalitis in mice.

1994 • 75 citations

Predominant expansion of V gamma 9/V delta 2 T cells in a tularemia patient

1992 • 74 citations

Polymorphisms in the tumor necrosis factor alpha (TNF-alpha) gene correlate with murine resistance to development of toxoplasmic encephalitis and with levels of TNF-alpha mRNA in infected brain tissue.

1992 • 72 citations

Gamma delta T cells play an important role in hsp65 expression and in acquiring protective immune responses against infection with Toxoplasma gondii.

1995 • 71 citations

Antibody against interleukin-6 reduces inflammation and numbers of cysts in brains of mice with toxoplasmic encephalitis

1994 • 65 citations

Preferential activation and expansion of human peripheral blood gamma delta T cells in response to Toxoplasma gondii in vitro and their cytokine production and cytotoxic activity against T. gondii-infected cells.

1995 • 64 citations

Antigen Presentation by Toxoplasma gondii-Infected Cells to CD4 + Proliferative T Cells and CD8 + Cytotoxic Cells

1989 • 64 citations

Phenotypic profile and functional characteristics of human gamma and delta T cells during acute toxoplasmosis

1992 • 57 citations

Induction of heat shock protein closely correlates with protection against Toxoplasma gondii infection.

1992 • 39 citations

The role of γδ T lymphocytes in infection

1991 • 33 citations

Cachectin - Tumour necrosis factor: A cytokine that mediates injury initiated by invasive parasites

1987 • 27 citations

Deleted Work

1955 • 0 citations