Natural Immunity: A T‐Cell‐Independent Pathway of Macrophage Activation, Defined in the scid Mouse

Biology of Natural Killer Cells

1989 • 2,970 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

CELLULAR RESISTANCE TO INFECTION

1962 • 1,422 citations

Antigen-Presenting Function of the Macrophage

1984 • 1,164 citations

The role of IL-10 in crossregulation of TH1 and TH2 responses

1991 • 775 citations

The Leukocyte Common Antigen Family

1989 • 741 citations

Response of resting human peripheral blood natural killer cells to interleukin 2.

1984 • 616 citations

Requirement of endogenous interferon-gamma production for resolution of Listeria monocytogenes infection.

1985 • 555 citations

Prostaglandins modulate macrophage Ia expression

1982 • 545 citations

A glycolipid on the surface of mouse natural killer cells

1980 • 539 citations

Functional diversity of T lymphocytes due to secretion of different cytokine patterns

1991 • 530 citations

The Role of Cell-Mediated Immunity in Bacterial Infections

1981 • 452 citations

Evidence that tumor necrosis factor has an important role in antibacterial resistance.

1989 • 422 citations

Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.

1989 • 385 citations

Natural killer cells: definition of a cell type rather than a function

1987 • 385 citations

Natural killer (NK) cells are present in mice with severe combined immunodeficiency (scid).

1985 • 362 citations

REQUIREMENT OF THYMUS (T) LYMPHOCYTES FOR RESISTANCE TO LISTERIOSIS

1972 • 352 citations

Interleukin 2 Regulates Expression of Its Receptor and Synthesis of Gamma Interferon by Human T Lymphocytes

1984 • 350 citations

Effects of natural and recombinant IL 2 on regulation of IFN gamma production and natural killer activity: lack of involvement of the Tac antigen for these immunoregulatory effects.

1984 • 310 citations

Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. I. Characterization of natural killer cell induction

1978 • 296 citations

Natural killer (NK) cells as a responder to interleukin 2 (IL 2). II. IL 2-induced interferon gamma production.

1983 • 288 citations

Monoclonal antibodies to murine gamma-interferon which differentially modulate macrophage activation and antiviral activity.

1985 • 286 citations

Natural killer cells: definition of a cell type rather than a function.

1986 • 278 citations

Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in scid mice.

1989 • 275 citations

Importance of thymus-derived lymphocytes in cell-mediated immunity to infection

1973 • 268 citations

Molecular Transductional Mechanisms by which IFNγ and Other Signals Regulate Macrophage Development

1987 • 266 citations

Resistance to Tuberculosis

1964 • 249 citations

Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay.

1990 • 247 citations

Production of tumor necrosis factor during murine listeriosis.

1987 • 241 citations

Activated macrophages in congenitally athymic "nude mice" and in lethally irradiate mice.

1975 • 240 citations

A T cell-independent mechanism of macrophage activation by interferon-gamma.

1987 • 239 citations

Regulation of macrophage populations. I. Preferential induction of Ia-rich peritoneal exudates by immunologic stimuli.

1980 • 231 citations

Gamma interferon limits access of Listeria monocytogenes to the macrophage cytoplasm.

1989 • 215 citations

Regulation of gamma interferon production by natural killer cells in scid mice: roles of tumor necrosis factor and bacterial stimuli

1991 • 215 citations

Effects of interferon-gamma and tumor necrosis factor-alpha on the expression of an Ia antigen on a murine macrophage cell line.

1986 • 199 citations

Natural killer (NK) cells as a responder to interleukin 2 (IL 2). I. Proliferative response and establishment of cloned cells.

1983 • 196 citations

Regulation of murine macrophage Ia antigen expression by an immune interferon-like lymphokine: inhibitory effect of endotoxin.

1982 • 193 citations

Lymphokine-activated killer cells, natural killer cells and cytokines

1991 • 182 citations

Molecules and structures involved in the adhesion of natural killer cells to vascular endothelium.

1991 • 163 citations

Demonstration of a soluble mediator that induces exudates rich in Ia-positive macrophages.

1980 • 148 citations

Activated Macrophages in Congenitally Athymic “Nude” Mice and in Lethally Irradiated Mice

1975 • 143 citations

On the mechanism of T cell-independent anti-Listeria resistance in nude mice.

1980 • 113 citations

Listeria monocytogenes infection in nude mice

1975 • 110 citations

Regulation of macrophage Ia expression in mice with severe combined immunodeficiency: induction of Ia expression by a T cell-independent mechanism.

1986 • 110 citations

Transplantable progenitors of natural killer cells are distinct from those of T and B lymphocytes.

1986 • 107 citations

Interferon-gamma induction by lipopolysaccharide: dependence on interleukin 2 and macrophages.

1986 • 100 citations

Anomalous high native resistance to athymic mice to bacterial pathogens

1977 • 93 citations

Regulation of human polymorphonuclear neutrophil (PMN) activity against Candida albicans by large granular lymphocytes via release of a PMN-activating factor.

1987 • 82 citations

BCG-induced murine effector cells. II. Characterization of natural killer cells in peritoneal exudates.

1977 • 79 citations

The functional significance of the regulation of macrophage Ia expression by endogenous arachidonate metabolites in vitro.

1986 • 78 citations

Natural killer activity in the peritoneal exudates of mice infected with Listeria monocytogenes: characterization of the natural killer cells by using a monoclonal rat anti-murine macrophage antibody (M1/70).

1981 • 76 citations

The function of antigen-presenting cells in mice with severe combined immunodeficiency.

1985 • 76 citations

Mechanistic studies of transforming growth factor-beta inhibition of IL-2-dependent activation of CD3- large granular lymphocyte functions. Regulation of IL-2R beta (p75) signal transduction.

1991 • 75 citations

Macrophage activation in murine African trypanosomiasis

1983 • 71 citations

Regulation of B lymphocytes by natural killer cells. Role of IFN-gamma.

1989 • 71 citations

Roles of CD4+ and CD8+ cells, and the effect of administration of recombinant murine interferon gamma in listerial infection.

1990 • 68 citations

Evidence that endogenous gamma interferon is produced early in Listeria monocytogenes infection

1990 • 60 citations

Corynebacterium parvum-Induced Peritoneal Exudate Cells with Rapid Cytolytic Activity against Tumour Cells are Non-Phagocytic Cells with Characteristics of Natural Killer Cells

1978 • 58 citations

The role of IL-10 in crossregulation of TH1 and TH2 responses

1991 • 54 citations

Resistance to Mycoplasma pulmonis Mediated by Activated Natural Killer Cells

1990 • 48 citations

An expanded population of natural killer cells in mice with severe combined immunodeficiency (SCID) lack rearrangement and expression of T cell receptor genes.

1986 • 47 citations

Role of gamma interferon in induction of natural killer activity by Legionella pneumophila in vitro and in an experimental murine infection model

1988 • 46 citations

Analysis of the time course of IFN-gamma mRNA and protein production during primary murine listeriosis. The immune phase of bacterial elimination is not temporally linked to IFN production in vivo.

1991 • 39 citations

The effects of beryllium and other adjuvants on Ia expression by macrophages.

1985 • 37 citations

BCG-Induced Murine Effector Cells

1977 • 34 citations

Role of tumor necrosis factor in Listeria resistance of nude mice

1990 • 32 citations

T Cell-Independent Macrophage Activation in Scid Mice

1989 • 28 citations

Pathology of Listeria infection in murine severe combined immunodeficiency. A study by immunohistochemistry and electron microscopy.

1988 • 27 citations

Induction of macrophage Ia expression by lipopolysaccharide and Listeria monocytogenes in congenitally athymic nude mice.

1987 • 24 citations

Recombinant interleukin 2‐activated natural killer cells regulate IgG_2a production

1990 • 24 citations

Modulation of natural killer activity in mice following infection with Listeria monocytogenes

1984 • 17 citations

Activation of non-specific cytotoxic cells in Listeria-susceptible and -resistant mouse strains.

1985 • 8 citations