Experimental Cutaneous Leishmaniasis: Langerhans Cells Internalize Leishmania Major and Induce an Antigen-Specific T-Cell Response

Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.

1983 • 1,918 citations

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies.

1987 • 592 citations

Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.

1989 • 542 citations

Epidermal Langerhans cells bear Fc and C3 receptors

1977 • 541 citations

Langerhans' cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody.

1986 • 478 citations

Macrophage complement and lectin-like receptors bind Leishmania in the absence of serum.

1985 • 306 citations

Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function

1991 • 286 citations

In vitro evidence that Langerhans cells can adopt two functionally distinct forms capable of antigen presentation to T lymphocytes.

1989 • 177 citations

Epidermal Langerhans Cells

2024 • 172 citations

A study of the differential respiratory burst activity elicited by promastigotes and amastigotes of Leishmania donovani in murine resident peritoneal macrophages.

1984 • 164 citations

The Thy-1-bearing cell of murine epidermis. A distinctive leukocyte perhaps related to natural killer cells.

1985 • 138 citations

Lymphocytes play the music but the macrophage calls the tune

1991 • 77 citations

Resistance to murine cutaneous leishmaniasis is mediated by T_H1 cells, but disease‐promoting CD4⁺ cells are different from T_H2 cells

1990 • 69 citations

Murine epidermal Langerhans cells are potent stimulators of an antigen‐specific T cell response to Leishmania major, the cause of cutaneous leishmaniasis

1992 • 47 citations

A reliable method for simultaneous demonstration of two antigens using a novel combination of immunogold-silver staining and immunoenzymatic labeling.

1990 • 35 citations