Ras/Rac-Dependent Activation of p38 Mitogen-Activated Protein Kinases in Smooth Muscle Cells Stimulated by Cyclic Strain Stress

The MAPK signaling cascade

1995 • 3,300 citations

Flow-mediated endothelial mechanotransduction

1995 • 2,728 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Organization and regulation of mitogen-activated protein kinase signaling pathways

1999 • 1,288 citations

Laminar Shear Stress

1998 • 1,052 citations

Enhanced Gαq signaling: A common pathway mediates cardiac hypertrophy and apoptotic heart failure

1998 • 528 citations

p38 Mitogen-activated Protein Kinase Regulates Cyclooxygenase-2 mRNA Stability and Transcription in Lipopolysaccharide-treated Human Monocytes

1999 • 495 citations

A new vacuum-operated stress-providing instrument that applies static or variable duration cyclic tension or compression to cells in vitro

1985 • 402 citations

A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration

1999 • 401 citations

Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways

1999 • 386 citations

Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF.

1993 • 368 citations

Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition

1998 • 344 citations

The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.

1996 • 338 citations

Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases

1997 • 314 citations

Regulation of Vascular Smooth Muscle Cell Migration and Proliferation In Vitro and in Injured Rat Arteries by a Synthetic Matrix Metalloproteinase Inhibitor

1996 • 311 citations

Angiotensin II Partly Mediates Mechanical Stress–Induced Cardiac Hypertrophy

1995 • 309 citations

NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells.

1999 • 288 citations

Induction of Collagenase-3 (MMP-13) Expression in Human Skin Fibroblasts by Three-dimensional Collagen Is Mediated by p38 Mitogen-activated Protein Kinase

1999 • 282 citations

The Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Cascade Activation Is a Key Signalling Pathway Involved in the Regulation of G₁ Phase Progression in Proliferating Hepatocytes

1999 • 255 citations

NF-κB-Inducing Kinase Is a Common Mediator of IL-17-, TNF-α-, and IL-1β-Induced Chemokine Promoter Activation in Intestinal Epithelial Cells

1999 • 252 citations

Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.

1998 • 238 citations

Pressure-induced arterial wall stress and atherosclerosis

1995 • 236 citations

CREB is activated by UVC through a p38/HOG-1-dependent protein kinase

1997 • 217 citations

Activation of PDGF receptor α in vascular smooth muscle cells by mechanical stress

1998 • 216 citations

Differential activation of ERK, JNK/SAPK and P3/CSBP/RK map kinase family members during the cellular response to arsenite

1996 • 211 citations

Cyclic Strain Stress-induced Mitogen-activated Protein Kinase (MAPK) Phosphatase 1 Expression in Vascular Smooth Muscle Cells Is Regulated by Ras/Rac-MAPK Pathways

1999 • 207 citations

Acute hypertension activates mitogen-activated protein kinases in arterial wall.

1996 • 200 citations

p38 Kinase Activity Is Essential for Osmotic Induction of mRNAs for HSP70 and Transporter for Organic Solute Betaine in Madin-Darby Canine Kidney Cells

1998 • 185 citations

Gq Signaling in Cardiac Adaptation and Maladaptation

1999 • 173 citations

Activation of Mitogen-Activated Protein Kinases (ERK/JNK) and AP-1 Transcription Factor in Rat Carotid Arteries After Balloon Injury

1997 • 171 citations

Both Gs and Gi Proteins Are Critically Involved in Isoproterenol-induced Cardiomyocyte Hypertrophy

1999 • 153 citations

Mechanical Strain Tightly Controls Fibroblast Growth Factor-2 Release From Cultured Human Vascular Smooth Muscle Cells

1997 • 146 citations

Mechanical Stretch Induces Hypertrophic Responses in Cardiac Myocytes of Angiotensin II Type 1a Receptor Knockout Mice

1998 • 145 citations

Nitric oxide induces heat-shock protein 70 expression in vascular smooth muscle cells via activation of heat shock factor 1.

1997 • 144 citations

A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy.

1998 • 142 citations

Central Role of the MAPK Pathway in Ang II–Mediated DNA Synthesis and Migration in Rat Vascular Smooth Muscle Cells

1999 • 136 citations

Mechanism of shear-induced prostacyclin production in endothelial cells

1989 • 136 citations

Cell Replication in the Arterial Wall

1998 • 127 citations

Inhibition of Neointima Hyperplasia of Mouse Vein Grafts by Locally Applied Suramin

1999 • 124 citations

Crosstalk Between Protein Kinase A and Growth Factor Receptor Signaling Pathways in Arterial Smooth Muscle

1999 • 122 citations

Roles of Extracellular Signal‐regulated Kinase 1/2 and p38 Mitogen‐activated Protein Kinase in the Signal Transduction of Basic Fibroblast Growth Factor in Endothelial Cells during Angiogenesis

1999 • 122 citations

Acute Hypertension Induces Heat-Shock Protein 70 Gene Expression in Rat Aorta

1995 • 113 citations

Activation of JNK/SAPK and ERK by Mechanical Strain in Vascular Smooth Muscle Cells Depends on Extracellular Matrix Composition

1997 • 98 citations

Activation of MAP Kinase In Vivo Follows Balloon Overstretch Injury of Porcine Coronary and Carotid Arteries

1997 • 97 citations

Hypertensive structural changes in systemic precapillary resistance vessels

1995 • 92 citations

Interleukin-1β Regulation of the Human Brain Natriuretic Peptide Promoter Involves Ras-, Rac-, and p38 Kinase–Dependent Pathways in Cardiac Myocytes

1999 • 92 citations

Shear Stress and Cyclic Strain Modulation of Gene Expression in Vascular Endothelial Cells

1995 • 92 citations

Oxidant Stress Incites Spreading of Macrophages via Extracellular Signal-Regulated Kinases and p38 Mitogen-Activated Protein Kinase

1998 • 84 citations

New perspectives in hypertension research. Potentials of vascular biology.

1994 • 81 citations

Enhancement of fibroblast collagenase-1 (MMP-1) gene expression by tumor promoter okadaic acid is mediated by stress-activated protein kinases jun N-terminal kinase and p38

1998 • 80 citations

G proteins as drug targets

1999 • 68 citations

Discordant Activation of Stress-activated Protein Kinases or c-Jun NH2-terminal Protein Kinases in Tissues of Heat-stressed Mice

1997 • 67 citations

Hyperexpression and Activation of Extracellular Signal–Regulated Kinases (ERK1/2) in Atherosclerotic Lesions of Cholesterol-Fed Rabbits

2000 • 66 citations

Regulation of Vascular Smooth Muscle Migration by Mitogen-activated Protein Kinase and Calcium/Calmodulin-dependent Protein Kinase II Signaling Pathways

1998 • 60 citations

The Regulation of p42/p44 Mitogen-Activated Protein Kinases in the Injured Rat Carotid Artery

1997 • 50 citations

Regulation of System A amino acid transport in L6 rat skeletal muscle cells by insulin, chemical and hyperthermic stress

1998 • 49 citations

Activin A and TGF-β Stimulate Phosphorylation of Focal Adhesion Proteins and Cytoskeletal Reorganization in Rat Aortic Smooth Muscle Cells

1999 • 49 citations

LDL Stimulates Mitogen-Activated Protein Kinase Phosphatase-1 Expression, Independent of LDL Receptors, in Vascular Smooth Muscle Cells

1999 • 37 citations

Mechanical endothelial damage results in basic fibroblast growth factor–mediated activation of extracellular signal-regulated kinases

1999 • 37 citations

G-Protein-Mediated Signaling in Cholesterol-Enriched Arterial Smooth Muscle Cells. 1. Reduced Membrane-Associated G-Protein Content Due to Diminished Isoprenylation of G-γ Subunits and p21ras

1997 • 24 citations

Decline of shear stress-induced activation of extracellular signal-regulated kinases, but not stress-activated protein kinases, in in vitro propagated endothelial cells

1998 • 14 citations