The endothelin receptor antagonist, bosentan, in combination with the cyclooxygenase inhibitor, diclofenac, counteracts pulmonary hypertension in porcine endotoxin shock

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

1993 • 1,829 citations

The Pathogenesis of Sepsis

1991 • 1,376 citations

Increased Plasma Endothelin-1 in Pulmonary Hypertension: Marker or Mediator of Disease?

1991 • 983 citations

Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.

1994 • 650 citations

Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure

1995 • 575 citations

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

1990 • 536 citations

The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo

1992 • 405 citations

Increased plasma endothelin-1 in the early hours of acute myocardial infarction

1991 • 298 citations

Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay

1989 • 265 citations

Friedman and Quade tests: BASIC computer program to perform nonparametric two-way analysis of variance and multiple comparisons on ranks of several related samples

1987 • 231 citations

Septic shock. Hemodynamics and pathogenesis.

1983 • 229 citations

Conversion of Big Endothelin-1 to 21-Residue Endothelin-1 Is Essential for Expression of Full Vasoconstrictor Activity

1989 • 184 citations

Prostaglandin E1 and Nitroglycerin Reduce Pulmonary Capillary Pressure but Worsen Ventilation—Perfusion Distributions in Patients with Adult Respiratory Distress Syndrome

1989 • 173 citations

Modulation by prostaglandin synthesis inhibitors of the action of exogenous angiotensin II on glomerular ultrafiltration in the rat.

1978 • 162 citations

Plasma endothelin concentrations in humans with end-stage heart failure and after heart transplantation

1992 • 159 citations

Septic Shock

1983 • 155 citations

Role of Thromboxane and Prostacyclin in Pulmonary Vasomotor Changes after Endotoxin in Dogs

1981 • 151 citations

[63] Catecholamine measurements in plasma by high-performance liquid chromatography with electrochemical detection

1987 • 150 citations

Effect of different endothelin receptor antagonists and of the novel non‐peptide antagonist Ro 46‐2005 on endothelin levels in rat plasma

1993 • 122 citations

Tissue specific distribution, clearance and vascular effects of endothelin in the pig

1989 • 110 citations

Production of Endothelin-1 in Vascular Endothelial Cells Is Regulated by Factors Associated with Vascular Injury

1992 • 98 citations

Effects of endothelin on the coronary vascular bed in open-chest dogs.

1989 • 94 citations

Nitric oxide inhalation attenuates pulmonary hypertension and improves gas exchange in endotoxin shock

1993 • 86 citations

Endothelin inhibits presynaptic adrenergic neurotransmission in rat mesenteric artery

1989 • 81 citations

Regional effects and clearance of endothelin‐1 across pulmonary and splanchnic circulation

1992 • 76 citations

Differences in vascular effects and removal of endothelin‐1 in human lung, brain, and skeletal muscle,

1993 • 72 citations

The Effects of Tumor Necrosis Factor and Their Selective Inhibition By Ibuprofen

1989 • 69 citations

Bosentan‐improved cardiopulmonary vascular performance and increased plasma levels of endothelin‐1 in porcine endotoxin shock

1996 • 68 citations

Prostaglandins, cyclo-oxygenase inhibitors, and thromboxane synthetase inhibitors in the pathogenesis of multiple systems organ failure.

1989 • 55 citations

The clinical significance of prostaglandins and thromboxane as mediators of septic shock

1987 • 47 citations

Effects of indomethacin on the regional haemodynamic responses to low doses of endothelins and sarafotoxin

1990 • 46 citations

Prostaglandins, Cyclo-oxygenase Inhibitors, and Thromboxane Synthetase Inhibitors in the Pathogenesis of Multiple Systems Organ Failure

1989 • 45 citations

Effect of longstanding venous stasis and hypoproteinaemia on lymph flow in the rat tail

1991 • 38 citations

Effects of ibuprofen on neutrophil function and acute lung injury in canine endotoxin shock

1988 • 36 citations

Ibuprofen attenuates plasma tumor necrosis factor activity during sepsis-induced acute lung injury

1991 • 33 citations

Inhibitory effects of diclofenac on the endotoxin shock response in relation to endothelin turnover in the pig

1995 • 28 citations

Regulatory mechanisms of the vascular endothelium: an update.

1994 • 26 citations

RELEASE OF ENDOTHELIN IN RELATION TO TUMOR NECROSIS FACTOR-α IN PORCINE PSEUDOMONAS AERUGINOSA-INDUCED SEPTIC SHOCK

1994 • 23 citations

Prostaglandin and thromboxane levels during endotoxin-induced respiratory failure in pigs

1987 • 21 citations

Porcine intrinsic pulmonary and systemic vascular tone is endothelin‐dependent

1994 • 18 citations

Thromboxane A2-Receptor Blockade and Prostacyclin in Porcine Escherichia coli Shock

1989 • 16 citations

THROMBOXANE-BLOCKED SWINE AS AN EXPERIMENTAL MODEL OF SEVERE INTRAVASCULAR INFLAMMATION AND SEPTIC SHOCK

1995 • 14 citations