Glucocorticoid receptor binds cooperatively to adjacent recognition sites.

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system

1981 • 1,991 citations

STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS

1985 • 1,911 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

A two-step mechanism for the interaction of estradiol with rat uterus.

1968 • 1,013 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

lac repressor-operator interaction

1970 • 791 citations

Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene

1987 • 760 citations

Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation

1988 • 600 citations

Many Transcription Factors Interact Synergistically with Steroid Receptors

1988 • 517 citations

Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor

1987 • 512 citations

Cooperative binding of λ repressors to sites separated by integral turns of the DNA helix

1986 • 450 citations

Expression of rabies virus glycoprotein from a recombinant vaccinia virus

1984 • 448 citations

Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones

1984 • 442 citations

A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor

1988 • 439 citations

Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement

1987 • 428 citations

Synergistic action of the glucocorticoid receptor with transcription factors.

1988 • 407 citations

A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression.

1987 • 360 citations

lac repressor forms loops with linear DNA carrying two suitably spaced lac operators.

1987 • 353 citations

Oestrogen and glucocorticoid responsive elements are closely related but distinct

1987 • 353 citations

Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter

1986 • 336 citations

In vivo protein–DNA interactions in a glucocorticoid response element require the presence of the hormone

1986 • 328 citations

The HeLa cell protein TEF-1 binds specifically and cooperatively to two SV40 enhancer motifs of unrelated sequence

1988 • 301 citations

Sequences required for in vitro transcriptional activation of a Drosophila hsp 70 gene

1985 • 291 citations

Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells

1984 • 278 citations

The estrogen-responsive element as an inducible enhancer: DNA sequence requirements and conversion to a glucocorticoid-responsive element.

1987 • 268 citations

Relationship of the 90-kDa murine heat shock protein to the untransformed and transformed states of the L cell glucocorticoid receptor.

1987 • 267 citations

A region in the steroid binding domain determines formation of the non-DNA-binding, 9 S glucocorticoid receptor complex.

1988 • 267 citations

Contacts between hormone receptor and DNA double helix within a glucocorticoid regulatory element of mouse mammary tumor virus.

1984 • 247 citations

Cooperative DNA binding of the yeast transcriptional activator GAL4.

1988 • 227 citations

Upstream Operators Enhance Repression of the lac Promoter

1986 • 197 citations

A dimer of AraC protein contacts three adjacent major groove regions of the araI DNA site.

1985 • 197 citations

Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA-binding state

1988 • 186 citations

Steroid-free glucocorticoid receptor binds specifically to mouse mammary tumour virus DNA

1986 • 185 citations

Antiglucocorticosteroid effects suggest why steroid hormone is required for receptors to bind DNA in vivo but not in vitro

1987 • 179 citations

The DNA loop model for ara repression: AraC protein occupies the proposed loop sites in vivo and repression-negative mutations lie in these same sites.

1986 • 167 citations

DNA loops induced by cooperative binding of λ repressor

1986 • 165 citations

Distinct sequence elements involved in the glucocorticoid regulation of the mouse mammary tumor virus promoter identified by linker scanning mutagenesis

1986 • 158 citations

The molybdate-stabilized L-cell glucocorticoid receptor isolated by affinity chromatography or with a monoclonal antibody is associated with a 90-92-kDa nonsteroid-binding phosphoprotein.

1985 • 156 citations

In vivo DNA loops in araCBAD: size limits and helical repeat.

1989 • 128 citations

Association of DNA-bound progesterone receptors

1987 • 116 citations

Synergism of closely adjacent estrogen-responsive elements increases their regulatory potential

1988 • 105 citations

High expression of functional adenovirus DNA polymerase and precursor terminal protein using recombinant vaccinia virus

1988 • 94 citations

Synthetic lac operator mediates repression through lac repressor when introduced upstream and downstream from lac promoter.

1986 • 87 citations

Three binding sites for AraC protein are required for autoregulation of araC in Escherichia coli.

1988 • 41 citations