Divergent effects of co‐carcinogenic phorbol esters and a synthetic diacylglycerol on human neutrophil chemokinesis and granular enzyme secretion

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

N-formylmethionyl peptides as chemoattractants for leucocytes.

1975 • 871 citations

Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.

1983 • 705 citations

Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets

1983 • 589 citations

UV-Assay with Pyruvate and NADH

1974 • 580 citations

The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions

1981 • 518 citations

Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: structure-function assessments employing subunit-specific monoclonal antibodies.

1986 • 423 citations

Chemokinetic activity of arachidonic acid lipoxygenase products on leuocyctes of different species

1980 • 399 citations

Stimulus response coupling in the human neutrophil. II. Temporal analysis of changes in cytosolic calcium and calcium efflux.

1984 • 272 citations

The role of neutrophil membrane glycoprotein GP-150 in neutrophil adherence to endothelium in vitro

1985 • 268 citations

Ca2+ homeostasis in permeabilized human neutrophils. Characterization of Ca2+-sequestering pools and the action of inositol 1,4,5-triphosphate.

1984 • 266 citations

Stimulation of neutrophil oxidative metabolism by chemotactic peptides: influence of calcium ion concentration and cytochalasin B and comparison with stimulation by phorbol myristate acetate

1979 • 259 citations

Effect of phorbol 12-myristate 13-acetate and its analogue 4 alpha-phorbol 12,13-didecanoate on protein phosphorylation and lysosomal enzyme release in rabbit neutrophils.

1984 • 221 citations

Phorbol 12-myristate 13-acetate activates rabbit neutrophils without an apparent rise in the level of intracellular free calcium

1983 • 217 citations

Mechanism of action of the phorbol ester tumor promoters: Specific receptors for lipophilic ligands

1984 • 209 citations

Phorbol esters inhibit the fMet-Leu-Phe- and leukotriene B4-stimulated calcium mobilization and enzyme secretion in rabbit neutrophils.

1985 • 196 citations

Phorbol myristate acetate stimulates ATP-dependent calcium transport by the plasma membrane of neutrophils.

1984 • 193 citations

Role of secretory events in modulating human neutrophil chemotaxis.

1978 • 193 citations

Diacylglycerol, 1-oleoyl-2-acetyl-glycerol, stimulates superoxide-generation from human neutrophils

1984 • 189 citations

Phosphorylation of smooth muscle heavy meromyosin by calcium-activated, phospholipid-dependent protein kinase. The effect on actin-activated MgATPase activity.

1983 • 174 citations

Specific degranulation of human polymorphonuclear leukocytes

1974 • 162 citations

Correlation of human neutrophil secretion, chemoattractant receptor mobilization, and enhanced functional capacity.

1982 • 154 citations

Secretagogue-induced phosphoinositide metabolism in human leucocytes

1984 • 152 citations

Calcium-induced lysozyme secretion from human polymorphonuclear leukocytes

1974 • 148 citations

Endogenous protein phosphorylation by resting and activated human neutrophils

1983 • 143 citations

Chemoattractant receptor functions in human polymorphonuclear leukocytes are divergently altered by membrane fluidizers.

1982 • 140 citations

The differential mobilization of human neutrophil granules. Effects of phorbol myristate acetate and ionophore A23187.

1977 • 136 citations

A possible role of protein kinase C in signal-induced lysosomal enzyme release

1983 • 128 citations

Mechanisms of lysosomal enzyme release from human polymorphonuclear leukocytes. Effects of phorbol myristate acetate.

1975 • 123 citations

The Importance of the Mac‐1, LFA‐1 Glycoprotein Family in Monocyte and Granulocyte Adherence, Chemotaxis, and Migration into Inflammatory Sites: Insights from an Experiment of Nature

1986 • 111 citations

Neutrophil specific granules: a fuse that ignites the inflammatory response.

1984 • 96 citations

Leukotriene B4 mobilizes calcium without the breakdown of polyphosphoinositides and the production of phosphatidic acid in rabbit neutrophils.

1984 • 86 citations

Characterization of formylmethionyl-leucyl-phenylalanine stimulation of inositol trisphosphate accumulation in rabbit neutrophils.

1985 • 82 citations

THE EFFECTS OF SOME ANTIRHEUMATIC DRUGS ON AN in vitro MODEL OF HUMAN POLYMORPHONUCLEAR LEUCOCYTE CHEMOKINESIS

1980 • 81 citations

Receptor-mediated Modulation of Human Monocyte, Neutrophil, Lymphocyte, and Platelet Function by Phorbol Diesters

1982 • 80 citations

Biochemistry of macrophages.

1986 • 77 citations

Cytosolic calcium regulates phorbol diester binding affinity in intact phagocytes.

1986 • 76 citations

Evidence that phorbol ester interferes with stimulated Ca2+ redistribution by activating Ca2+ efflux in neutrophil leucocytes

1985 • 76 citations

Phorbol 12, myristate 13, acetate potentiates the respiratory burst while inhibits phosphoinositide hydrolysis and calcium mobilization by formyl-methionyl-leucyl-phenylalanine in human neutrophils

1986 • 73 citations

Inositol 1,4,5‐trisphosphate may be a signal for f‐Met‐Leu‐Phe‐induced intracellular Ca mobilisation in human leucocytes (HL‐60 cells)

1984 • 60 citations

Diacylglycerols enhance human neutrophil degranulation responses: Relevancy to a multiple mediator hypothesis of cell function

1984 • 53 citations

Inhibition of human neurophil degranulation by forskolin in the presence of phosphodiesterase inhibitors

1986 • 50 citations

Micromolar concentrations of free calcium provoke secretion of lysozyme from human neutrophils permeabilized with saponin.

1985 • 43 citations

CALCIUM IONOPHORE A23187 INDUCES RELEASE OF CHEMOKINETIC AND AGGREGATING FACTORS FROM POLYMORPHO‐NUCLEAR LEUCOCYTES

1980 • 42 citations

Phosphatidylinositol metabolism in mast cells and neutrophils

1982 • 41 citations

A guanine nucleotide regulatory protein controls polyphosphoinositide metabolism, Ca2+ mobilization, and cellular responses to chemoattractants in human monocytes.

1986 • 41 citations

Relationships between phosphoinositide metabolism, Ca²⁺ changes and respiratory burst in formyl‐methionyl‐leucyl‐ phenylalanine‐stimulated human neutrophils

1985 • 34 citations

Protein kinase C as a bidirectional regulator of cell function

1985 • 33 citations

Dual role for guanine nucleotides in stimulus-secretion coupling.

1986 • 29 citations

A comparison of the effects of soluble stimuli on free cytoplasmic and membrane bound calcium in human neutrophils

1984 • 26 citations

Phorbol myristate acetate enhances human polymorphonuclear neutrophil release of granular enzymes but inhibits chemokinesis

1985 • 22 citations

Diacylglycerols and mezerein activate neutrophils by a phorbol myristate acetate‐like mechanism

1985 • 21 citations

The motor of leukocytes.

1984 • 19 citations