Direct Evidence That Involucrin Is a Major Early Isopeptide Cross-linked Component of the Keratinocyte Cornified Cell Envelope

Transglutaminases: multifunctional cross‐linking enzymes that stabilize tissues

1991 • 999 citations

Transglutaminases

1980 • 818 citations

The cornified envelope of terminally differentiated human epidermal keratinocytes consists of cross-linked protein

1977 • 532 citations

The Proteins Elafin, Filaggrin, Keratin Intermediate Filaments, Loricrin, and Small Proline-rich Proteins 1 and 2 Are Isodipeptide Cross-linked Components of the Human Epidermal Cornified Cell Envelope

1995 • 508 citations

The keratinocyte handbook

1995 • 428 citations

Identification of a major keratinocyte cell envelope protein, loricrin

1990 • 420 citations

Structure and evolution of the human involucrin gene

1986 • 393 citations

Keratins. Their composition, structure and biosynthesis

1973 • 370 citations

Lipid and protein structures in the permeability barrier of mammalian epidermis.

1992 • 313 citations

Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins.

1991 • 305 citations

Stratification and terminal differentiation of cultured epidermal cells

1982 • 300 citations

Involucrin synthesis is correlated with cell size in human epidermal cultures.

1981 • 298 citations

Expression of epidermal keratins and filaggrin during human fetal skin development.

1985 • 284 citations

A leucine→proline mutation in the H1 subdomain of keratin 1 causes epidermolytic hyperkeratosis

1992 • 284 citations

Structure of the human desmoplakins. Implications for function in the desmosomal plaque.

1990 • 275 citations

Cellular and Molecular Biology of Intermediate Filaments

1990 • 262 citations

Participation of membrane-associated proteins in the formation of the cross-linked envelope of the keratinocyte

1984 • 257 citations

Protein composition of cornified cell envelopes of epidermal keratinocytes

1994 • 246 citations

The α6β1 (VLA-6) and α6β4 protein complexes: tissue distribution and biochemical properties

1990 • 219 citations

A Model for the Surface of Keratin Fibers

1993 • 219 citations

Molecular Characterization and Evolution of the SPRR Family of Keratinocyte Differentiation Markers Encoding Small Proline-Rich Proteins

1993 • 204 citations

Keratins. Their composition, structure and biosynthesis

1973 • 194 citations

Defects in the Barrier

1995 • 188 citations

Biosynthetic pathways of filaggrin and loricrin—two major proteins expressed by terminally differentiated epidermal keratinocytes

1990 • 187 citations

Synthetic peptides corresponding to keratin subunits elicit highly specific antibodies.

1984 • 186 citations

Cornified Cell Envelope

1990 • 184 citations

Involucrin—Structure and Role in Envelope Assembly

1993 • 181 citations

Comparative structural analysis of desmoplakin, bullous pemphigoid antigen and plectin: members of a new gene family involved in organization of intermediate filaments

1992 • 169 citations

Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes.

1988 • 169 citations

Identification of Late Differentiation Antigens of Human Cornified Epithelia, Expressed in Re-Organized Desmosomes and Bound to Cross-Linked Envelope

1991 • 165 citations

SKALP/elafin: an elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase cross-linking

1993 • 164 citations

Comparison of molecularly cloned bullous pemphigoid antigen to desmoplakin I confirms that they define a new family of cell adhesion junction plaque proteins

1991 • 162 citations

The Small Proline-Rich Proteins Constitute a Multigene Family of Differentially Regulated Cornified Cell Envelope Precursor Proteins

1995 • 162 citations

The structure of human trichohyalin. Potential multiple roles as a functional EF-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein

1993 • 160 citations

Biochemical, Structural, and Transglutaminase Substrate Properties Of Human Loricrin, the Major Epidermal Cornified Cell Envelope Protein

1995 • 158 citations

Cornifin, a cross-linked envelope precursor in keratinocytes that is down-regulated by retinoids.

1992 • 158 citations

The polypeptide composition of bovine epidermal α-keratin

1975 • 153 citations

Immunochemical characterization of three components of the hemidesmosome and their expression in cultured epithelial cells.

1989 • 152 citations

Lipids and the epidermal water barrier: metabolism, regulation, and pathophysiology.

1992 • 151 citations

A 300,000-mol-wt intermediate filament-associated protein in baby hamster kidney (BHK-21) cells.

1985 • 129 citations

Human plectin: organization of the gene, sequence analysis, and chromosome localization (8q24).

1996 • 127 citations

Keratolinin: the soluble substrate of epidermal transglutaminase from human and bovine tissue.

1984 • 107 citations

The human loricrin gene.

1992 • 105 citations

epsilon-(gamma-Glutamyl)lysine cross-links in human stratum corneum.

1977 • 101 citations

Effects of UV, 4NQO and TPA on gene expression in cultured human epidermal keratinocytes

1987 • 100 citations

IFAP 300 is common to desmosomes and hemidesmosomes and is a possible linker of intermediate filaments to these junctions.

1994 • 92 citations

Tissue-specific and differentiation-appropriate expression of the human involucrin gene in transgenic mice: an abnormal epidermal phenotype

1993 • 89 citations

The glutamine residues reactive in transglutaminase-catalyzed cross-linking of involucrin.

1988 • 87 citations

A model for the hierarchical structure of the human epidermal cornified cell envelope.

1995 • 79 citations

The Molecular Biology of Skin

1976 • 75 citations

Sequence and Expression Patterns of Mouse SPR1: Correlation of Expression with Epithelial Function

1996 • 73 citations

Phosphorylated cystatin α is a natural substrate of epidermal transglutaminase for formation of skin cornified envelope

1992 • 73 citations

Immunoelectron microscopic analysis of cornified cell envelope formation in normal and psoriatic epidermis.

1996 • 72 citations

Overexpression of human loricrin in transgenic mice produces a normal phenotype.

1993 • 68 citations

Immuno-ultrastructural localization of involucrin in squamous epithelium and cultured keratinocytes.

1985 • 68 citations

Biophysical characterization of involucrin reveals a molecule ideally suited to function as an intermolecular cross-bridge of the keratinocyte cornified envelope.

1992 • 67 citations

Up-Regulation of Elafin/SKALP Gene Expression in Psoriatic Epidermis

1994 • 67 citations

Lipids Are Covalently Attached to Rigid Corneocyte Protein Envelopes Existing Predominantly as β-Sheets: A Solid-State Nuclear Magnetic Resonance Study

1995 • 67 citations

Primary structure of the human elafin precursor preproelafin deduced from the nucleotide sequence of its gene and the presence of unique repetitive sequences in the prosegment

1992 • 66 citations

Involucrin Is a Covalently Crosslinked Constituent of Highly Purified Epidermal Corneocytes: Evidence for a Common Pattern of Involucrin Crosslinking in Vivo and in Vitro

1996 • 64 citations

Evidence that Involucrin Is a Covalently Linked Constituent of Highly Purified Cultured Keratinocyte Cornified Envelopes

1993 • 62 citations

Skin-derived antileukoproteinase (SKALP), an elastase inhibitor from human keratinocytes. Purification and biochemical properties

1991 • 56 citations

Evidence for filaggrin as a component of the cell envelope of the newborn rat

1988 • 52 citations

Differentiation-dependent changes in the solubility of a 195-kD protein in human epidermal keratinocytes.

1986 • 50 citations

A panel of monoclonal antibodies to rat plectin: Distinction by epitope mapping and immunoreactivity with different tissues and cell lines

1994 • 49 citations

Premature translation termination of the pre-E1 alpha subunit of the branched chain alpha-ketoacid dehydrogenase as a cause of maple syrup urine disease in Polled Hereford calves.

1990 • 46 citations

Identification of a 450-kDa Human Epidermal Autoantigen as a New Member of the Plectin Family

1996 • 46 citations

Differential expression and cell envelope incorporation of small proline-rich protein 1 in different cornified epithelia

1996 • 44 citations

Involucrin acts as a transglutaminase substrate at multiple sites

1986 • 44 citations

Consecutive actions of different gene-altering mechanisms in the evolution of involucrin.

1992 • 43 citations

The Pancornulins: A Group of Small Proline Rich-Related Cornified Envelope Precursors with Bifunctional Capabilities in Isopeptide Bond Formation

1995 • 43 citations

Characterization of the Mouse Loricrin Gene: Linkage with Profilaggrin and the Flaky Tail and Soft Coat Mutant Loci on Chromosome 3

1994 • 40 citations

Covalently Linked Fatty Acids at the Surface of Wool: Part of the "Cuticle Cell Envelope"

1994 • 38 citations

An involucrin-like protein in hepatocytes serves as a substrate for tissue transglutaminase during apoptosis.

1992 • 35 citations

Involucrin mRNA Is More Abundant in Human Hair Follicles Than in Normal Epidermis

1994 • 35 citations

Covalently bound lipids in keratinizing epithelia

1993 • 33 citations