Retinoic Acid Receptor α Function in Vertebrate Limb Skeletogenesis: a Modulator of Chondrogenesis

Function of the retinoic acid receptors (RARs) during development: (II) Multiple abnormalities at various stages of organogenesis in RAR double mutants

1994 • 987 citations

SPECIFIC STAINING OF SULPHATE GROUPS WITH ALCIAN BLUE AT LOW pH

1964 • 917 citations

Multiplicity generates diversity in the retinoic acid signalling pathways

1992 • 836 citations

Cloning of murine α and β retinoic acid receptors and a novel receptor γ predominantly expressed in skin

1989 • 804 citations

Function of the retinoic acid receptors (RARs) during development: (I) Craniofacial and skeletal abnormalities in RAR double mutants

1994 • 755 citations

A positive feedback loop coordinates growth and patterning in the vertebrate limb

1994 • 702 citations

A third human retinoic acid receptor, hRAR-gamma.

1989 • 686 citations

Genetic analysis of RXRα developmental function: Convergence of RXR and RAR signaling pathways in heart and eye morphogenesis

1994 • 684 citations

Local application of retinoic acid to the limb bond mimics the action of the polarizing region

1982 • 669 citations

FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb

1993 • 660 citations

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.

1994 • 632 citations

Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S

1980 • 618 citations

Stage-related capacity for limb chondrogenesis in cell culture

1977 • 616 citations

Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation

1989 • 612 citations

Function of retinoic acid receptor γ in the mouse

1993 • 595 citations

Retinoic acid receptors and cellular retinoid binding proteins: I. A systematic study of their differential pattern of transcription during mouse organogenesis

1990 • 587 citations

High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice.

1993 • 541 citations

Retinoic acid receptors and cellular retinoid binding proteins : II. Their differential pattern of transcription during early morphogenesis in mouse embryos

1991 • 527 citations

Retinoic Acid Receptors and Cellular Retinoid Binding Proteins: Complex Interplay in Retinoid Signaling*

1994 • 514 citations

The retinoid signaling pathway: molecular and genetic analyses

1994 • 508 citations

Morphogenesis of malformations in hamsters caused by retinoic acid: Relation to dose and stage at treatment

1972 • 501 citations

Differential expression of genes encoding α, β and γ retinoic acid receptors and CRABP in the developing limbs of the mouse

1989 • 482 citations

Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo

1992 • 467 citations

A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1

1994 • 446 citations

Retinoids, homeoboxes, and growth factors: Toward molecular models for limb development

1991 • 410 citations

Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis

1990 • 351 citations

A quantitative analysis of the effect of all-trans-retinoic acid on the pattern of chick wing development

1985 • 312 citations

Developmental expression of murine retinoid X receptor (RXR) genes

1994 • 297 citations

Limb development in mouse embryos. I. Analysis of teratogenic effects of retinoic acid

1973 • 287 citations

Identification of a retinoic acid responsive enhancer 3′ of the murine homeobox gene Hox-1.6

1992 • 268 citations

Developmental analysis of the retinoic acid-inducible RAR-βJ2 promoter in transgenic animals

1991 • 258 citations

Retinoic acid receptors and cellular retinoid binding proteins III. Their differential transcript distribution during mouse nervous system development

1993 • 228 citations

The effect of local application of retinoic acid to the anterior margin of the developing chick limb

1983 • 210 citations

Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene.

1993 • 192 citations

Transgenic indicator mice for studying activated retinoic acid receptors during development.

1992 • 170 citations

Inhibition of limb chondrogenesis in vitro by vitamin A: Alterations in cell surface characteristics

1978 • 159 citations

Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hoxa-1 expression and differentiation upon retinoic acid treatment.

1993 • 143 citations

Targeted Disruption of Retinoic Acid Receptor α (RARα) and RARγ Results in Receptor-Specific Alterations in Retinoic Acid-Mediated Differentiation and Retinoic Acid Metabolism

1995 • 143 citations

Retinoic Acid Receptor β2 (RARβ2) Null Mutant Mice Appear Normal

1994 • 141 citations

Identification of a retinoic acid response element upstream of the murine Hox-4.2 gene.

1993 • 139 citations

A zebrafish retinoic acid receptor expressed in the regenerating caudal fin

1994 • 135 citations

Mice lacking all isoforms of retinoic acid receptor β develop normally and are susceptible to the teratogenic effects of retinoic acid

1995 • 132 citations

Retinoic‐acid‐induced limb malformations resulting from apical ectodermal ridge cell death

1988 • 131 citations

8 Retinoic Acid Receptors: Transcription Factors Modulating Gene Regulation, Development, and Differentiation

1992 • 107 citations

Retinoid receptors in vertebrate limb development

1992 • 97 citations

The selective inhibition of mucopolysaccharide synthesis by vitamin a treatment of cultured chick embryo chondrocytes

1973 • 95 citations

Retinoic acid application to chick wing buds leads to a dose-dependent reorganization of the apical ectodermal ridge that is mediated by the mesenchyme

1989 • 78 citations

Susceptible stages and abnormal morphogenesis in the developing mouse limb, analysed in organ culture after transplacental exposure to vitamin A (retinoic acid)

1974 • 71 citations

Production of congenital limb defects with retinoic acid: Phenomenological evidence of progressive differentiation during limb morphogenesis

1980 • 69 citations

Mouse embryos lacking RXRα are resistant to retinoic-acid-induced limb defects

1995 • 66 citations

Transgenic mice expressing a constitutively active retinoic acid receptor in the lens exhibit ocular defects

1992 • 61 citations

Polyvinyl alcohol enhances detection of low abundance transcripts in early stage quail embryos in a nonradioactive whole mount in situ hybridization technique.

1994 • 54 citations

Pattern of retinoid-induced teratogenic effects: Possible relationship with relative selectivity for nuclear retinoid receptors RARα, RARβ, and RARγ

1996 • 44 citations

A regulatory region from the mouse Hox-2.2 promoter directs gene expression into developing limbs

1991 • 41 citations

Teratogenesis by retinoic acid analogs positively correlates with elevation of retinoic acid receptor‐β2 mRNA levels in treated embryos

1994 • 36 citations

Evaluation of the sensitive step of inhibition of chondrogenesis by retinoids in limb mesenchymal cells in vitro

1985 • 33 citations

A retinoic acid receptor α antagonist counteracts retinoid teratogenicity in vitro and reduced incidence and/or severity of malformations in vivo

1994 • 32 citations

Identification of a Retinoic Acid Response Element Upstream of the Murine Hox-4.2 Gene

1993 • 23 citations

Differential expression of retinoic acid receptor‐β isoforms during chick limb ontogeny

1995 • 22 citations

Retinoic acid enhances and depresses in vitro development of cartilaginous bone anlagen in embryonic mouse limbs

1986 • 18 citations

The effects of natural and synthetic retinoids on the differentiation of RCJ C5.18 chondrogenic cells

1994 • 14 citations

Retinoids and Mouse Embryonic Development

1995 • 13 citations

Cited By (0)

Loading...