Interleukin 6 is autoregulated by transcriptional mechanisms in cultures of rat osteoblastic cells.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

1992 • 1,437 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.

1993 • 955 citations

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.

1993 • 827 citations

Comparing the Means of Several Groups

1985 • 750 citations

Interleukin-6 in human multiple myeloma

1995 • 550 citations

The soluble interleukin‐6 receptor is generated by shedding

1993 • 502 citations

Interleukin 6 is involved in interleukin 1‐induced activities

1988 • 422 citations

Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor

1992 • 388 citations

Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide.

1994 • 325 citations

Statistics in Practice

1983 • 308 citations

Perspectives: Interleukin-6: An osteotropic factor?

1992 • 283 citations

Interleukin-6 is produced by bone and modulated by parathyroid hormone

1989 • 237 citations

Increased and highly stable levels of functional soluble interleukin‐6 receptor in sera of patients with monoclonal gammopathy

1993 • 206 citations

Further biochemical and molecular characterization of primary rat parietal bone cell cultures

1988 • 203 citations

In Vitro Recombination and Mutagenesis of DNA: SOEing Together Tailor-Made Genes

2003 • 199 citations

Structure of the Rat Interleukin 6 Gene and Its Expression in Macrophage-derived Cells

1989 • 199 citations

Transcriptional regulation of the interferon-beta 2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines.

1988 • 183 citations

Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells.

1996 • 171 citations

The Modulation of the Expression of IL-6 and Its Receptor in Human Osteoblastsin Vitro*

1991 • 159 citations

Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption.

1995 • 136 citations

Osteotropic factor responsiveness of highly purified populations of early and late precursors for human multinucleated cells expressing the osteoclast phenotype

1991 • 119 citations

Serum soluble interleukin‐6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin‐6 signal

1993 • 106 citations

Platelet-Derived Growth Factor Enhances Deoxyribonucleic Acid and Collagen Synthesis in Osteoblast-Enriched Cultures from Fetal Rat Parietal Bone*

1989 • 96 citations

Regulation of IL6 gene expression

1992 • 94 citations

Multiple Regulatory Elements in the Interleukin-6 Gene Mediate Induction by Prostaglandins, Cyclic AMP, and Lipopolysaccharide

1994 • 85 citations

Relative binding and biochemical effects of heterodimeric and homodimeric isoforms of platelet‐derived growth factor in osteoblast‐enriched cultures from fetal rat bone

1991 • 77 citations

Soluble interleukin 6 receptor in biological fluids from human origin

1994 • 71 citations

Recombinant soluble human interleukin‐6 receptor

1993 • 67 citations

Statistical Data Analysis Handbook.

1988 • 63 citations

92238400 Increased osteoclast development after estrogen loss: Mediation by interleukin-6

1993 • 55 citations

The critical role of interleukin-6, interleukin-1B and macrophage colony-stimulating factor in the pathogenesis of bone lesions in multiple myeloma

1992 • 50 citations

Regulation of insulin-like growth factor I transcription by prostaglandin E2 in osteoblast cells.

1995 • 47 citations

The Soluble Interleukin-6 Receptora

1995 • 36 citations

A Nuclear Factor for the IL-6 Gene (NF-IL6)

1992 • 30 citations

Autocrine activity of interleukin 6 secreted by hepatocarcinoma cell lines.

1991 • 28 citations

Membrane‐bound and Soluble Interleukin‐6 Receptor: Studies on Structure, Regulation of Expression, and Signal Transductiona

1995 • 26 citations

Regulation of insulin-like growth factor I transcription by prostaglandin E2 in osteoblast cells

1995 • 21 citations

Statistical Data Analysis Handbook

1991 • 18 citations

A Nuclear Factor for the IL-6 Gene (NF-IL6)

2015 • 15 citations

In Vitro Recombination and Mutagenesis of DNA: SOEing Together Tailor-Made Genes

2003 • 13 citations