The Proteins Elafin, Filaggrin, Keratin Intermediate Filaments, Loricrin, and Small Proline-rich Proteins 1 and 2 Are Isodipeptide Cross-linked Components of the Human Epidermal Cornified Cell Envelope

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Transglutaminases: multifunctional cross‐linking enzymes that stabilize tissues

1991 • 999 citations

The cornified envelope of terminally differentiated human epidermal keratinocytes consists of cross-linked protein

1977 • 532 citations

Transglutaminases: Protein Cross-Linking Enzymes in Tissues and Body Fluids

1994 • 504 citations

Altered differentiation of mouse epidermal cells treated with retinyl acetate in vitro

1974 • 437 citations

Identification of a major keratinocyte cell envelope protein, loricrin

1990 • 420 citations

Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence.

1990 • 419 citations

Lipid and protein structures in the permeability barrier of mammalian epidermis.

1992 • 313 citations

Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins.

1991 • 305 citations

Expression of epidermal keratins and filaggrin during human fetal skin development.

1985 • 284 citations

Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins.

1994 • 283 citations

Structure of the human desmoplakins. Implications for function in the desmosomal plaque.

1990 • 275 citations

Protein composition of cornified cell envelopes of epidermal keratinocytes

1994 • 246 citations

Molecular Characterization and Evolution of the SPRR Family of Keratinocyte Differentiation Markers Encoding Small Proline-Rich Proteins

1993 • 204 citations

Glycine loops in proteins: their occurence in certain intermediate filament chains, loricrins and single-stranded RNA binding proteins

1991 • 194 citations

Biosynthetic pathways of filaggrin and loricrin—two major proteins expressed by terminally differentiated epidermal keratinocytes

1990 • 187 citations

Organization, structure, and polymorphisms of the human profilaggrin gene

1990 • 186 citations

Cornified Cell Envelope

1990 • 184 citations

Amino acid sequences of mouse and human epidermal type II keratins of Mr 67,000 provide a systematic basis for the structural and functional diversity of the end domains of keratin intermediate filament subunits.

1985 • 183 citations

Involucrin—Structure and Role in Envelope Assembly

1993 • 181 citations

Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes.

1988 • 169 citations

SKALP/elafin: an elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase cross-linking

1993 • 164 citations

The structure of human trichohyalin. Potential multiple roles as a functional EF-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein

1993 • 160 citations

Cornifin, a cross-linked envelope precursor in keratinocytes that is down-regulated by retinoids.

1992 • 158 citations

A Mutation in the V1 End Domain of Keratin 1 in Non-Epidermolytic Palmar-Plantar Keratoderma

1994 • 144 citations

Characterization of human cytokeratin 2, an Epidermal cytoskeletal protein synthesized late during differentiation

1992 • 129 citations

Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21.

1989 • 124 citations

Elastase Inhibitor Elafin Is a New Type of Proteinase Inhibitor Which Has a Transglutaminase-Mediated Anchoring Sequence Termed “Cementoin”1

1994 • 116 citations

Protransglutaminase E from guinea pig skin. Isolation and partial characterization.

1990 • 110 citations

The human loricrin gene.

1992 • 105 citations

epsilon-(gamma-Glutamyl)lysine cross-links in human stratum corneum.

1977 • 101 citations

Effects of UV, 4NQO and TPA on gene expression in cultured human epidermal keratinocytes

1987 • 100 citations

Postsynthetic modifications of mammalian epidermal .alpha.-keratin

1979 • 96 citations

Retinoic acid induces transglutaminase activity but inhibits cornification of cultured epidermal cells.

1982 • 93 citations

Immunocytochemical evidence for a possible role of cross-linked keratinocyte envelopes in stratum corneum cohesion.

1991 • 79 citations

A model for the hierarchical structure of the human epidermal cornified cell envelope.

1995 • 79 citations

The Molecular Biology of Skin

1976 • 75 citations

The structure of the transglutaminase 1 enzyme. Deletion cloning reveals domains that regulate its specific activity and substrate specificity.

1994 • 74 citations

The complete sequence of the human intermediate filament chain keratin 10. Subdomainal divisions and model for folding of end domain sequences.

1988 • 73 citations

Phosphorylated cystatin α is a natural substrate of epidermal transglutaminase for formation of skin cornified envelope

1992 • 73 citations

Overexpression of human loricrin in transgenic mice produces a normal phenotype.

1993 • 68 citations

Up-Regulation of Elafin/SKALP Gene Expression in Psoriatic Epidermis

1994 • 67 citations

Primary structure of the human elafin precursor preproelafin deduced from the nucleotide sequence of its gene and the presence of unique repetitive sequences in the prosegment

1992 • 66 citations

Evidence that Involucrin Is a Covalently Linked Constituent of Highly Purified Cultured Keratinocyte Cornified Envelopes

1993 • 62 citations

Identification and Subcellular Distribution of Cornified Envelope Precursor Proteins in the Transformed Human Keratinocyte Line SV-K14

1987 • 62 citations

Labeling of epsilon-lysine crosslinking sites in proteins with peptide substrates of factor XIIIa and transglutaminase.

1990 • 58 citations

Skin-derived antileukoproteinase (SKALP), an elastase inhibitor from human keratinocytes. Purification and biochemical properties

1991 • 56 citations

Evidence for filaggrin as a component of the cell envelope of the newborn rat

1988 • 52 citations

The Pancornulins: A Group of Small Proline Rich-Related Cornified Envelope Precursors with Bifunctional Capabilities in Isopeptide Bond Formation

1995 • 43 citations

The amine‐donor substrate specificity of tissue‐type transglutaminase

1994 • 37 citations

An involucrin-like protein in hepatocytes serves as a substrate for tissue transglutaminase during apoptosis.

1992 • 35 citations

The major clotting protein from guinea pig seminal vesicle contains eight repeats of a 24-amino acid domain.

1987 • 33 citations

A new class of soluble basic protein precursors of the cornified envelope of mammalian epidermis

1987 • 30 citations

The Cystine-Rich Envelope Protein From Human Epidermal Stratum Corneum Cells

1987 • 29 citations

Protein Modifications catalysed by Transglutaminase

1963 • 22 citations